Best practice for sepsis

Rello, Jordi; Rubulotta, Francesca

doi:10.21037/jtd.2018.03.29

Cited by 3 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We agree with the commentators that training of EMS personnel is important (1,2) and that the development and implementation of educational programs for the recognition and treatment of sepsis, should be a priority (1). A study which was conducted in the Netherlands, prior to the start of the PHANTASi trial, found an in-hospital mortality rate of 21% for septic patients who were transported by EMS (7), which was higher than the in-hospital mortality rate of 6% in the PHANTASi trial.…”

supporting

confidence: 71%

“…These patients often receive antibiotics despite having a viral infection. This also highlights the importance of training medical personnel in the recognition of sepsis, as well as the added value of developing and/or validating sepsis biomarkers, as already pointed out by both commentators (1,2).…”

mentioning

confidence: 59%

“…We read, with interest, the letters to editor by Rello et al (1) and Bolliger et al (2) in response to our Prehospital Antibiotics Against Sepsis (PHANTASi) trial which was recently published in the Lancet Respiratory Medicine (3).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Author’s response to commentary on the PHANTASi trial

et al. 2018

View full text Add to dashboard Cite

supporting

confidence: 71%

mentioning

confidence: 59%

See 1 more Smart Citation

Author’s response to commentary on the PHANTASi trial

et al. 2018

View full text Add to dashboard Cite

“…But the SOFA includes laboratory testing parameters, which take time to perform. Therefore, several rapid and simple emergency departments (ED) scoring systems, including quick sequential organ failure assessment (qSOFA) (7), systemic inflammatory response syndrome (SIRS) criterion (8), modified early warning score (MEWS) (9), and mortality in emergency department sepsis (MEDS) (10), have been used to predict the mortality for patients admitted to EDs under various circumstances. Additionally, some recent studies have suggested that the lactate-enhanced-quick sequential organ failure assessment (LqSOFA), which combines the bedside lactate and qSOFA, is a valuable and rapid predicting tool for mortality in sepsis patients (11,12).…”

Section: Introductionmentioning

confidence: 99%

Lactate-enhanced-qSOFA (LqSOFA) score is superior to the other four rapid scoring tools in predicting in-hospital mortality rate of the sepsis patients

Liu

et al. 2020

Ann Transl Med

View full text Add to dashboard Cite

Background: The rising prevalence of early therapy for sepsis has led to the demand for rapid riskstratification tools that can estimate the risk of in-hospital mortality for sepsis patients and the need for intensive care unit (ICU) admission. A robust risk-stratification tool is crucial for in-time sepsis treatment.This study aimed to compare the abilities of five rapid scoring systems, i.e., LqSOFA score, qSOFA score, SIRS, MEDS, and MEWS, in predicting the mortality in hospital and ICU admission for sepsis patients.Methods: A retrospective observational clinical study was conducted in West China Hospital. Our cases included all patients admitted to the hospital with a diagnosis of sepsis (sepsis-3). We calculated five rapid prediction scores for the enrolled cases. We then compared each rapid score's ability to predict in-hospital mortality and ICU admission.Results: A total of 821 of mixed sepsis patients by sepsis-3 definition were included. The all-cause hospital mortality rate was 21.1%. The LqSOFA score presented the most significant discrimination with an area under the receiver operating characteristic curve (AUC) of 0.751. The AUC of the LqSOFA score for mortality in the hospital was significantly higher than qSOFA (AUC 0.717), SIRS (AUC 0.704), MEDS (AUC 0.670), and MEWS (AUC 0.685). Conclusions:LqSOFA is a superior prognostic tool for predicting mortality in the hospital. It may provide more exact information for hospital mortality than the other 4 rapid scores in treating sepsis patients.

show abstract