Beryllium‐stimulated neopterin as a diagnostic adjunct in chronic beryllium disease

Maier, Lisa A.; Kittle, Lori A; Mroz, Margaret M.; Newman, Lee S.

doi:10.1002/ajim.10227

Cited by 12 publications

(6 citation statements)

References 31 publications

(44 reference statements)

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“…We purposely enrolled all study subjects who had a confirmed diagnosis of BeS or CBD, including subjects who had negative or borderline BeLPTs at the time of our analysis, to evaluate the utility of the ELISPOT assay in this population. The sensitivity of the BeLPT (65%) in this study was lower than previously reported 5,6,15 but similar to that recently reported by Maier et al 23 Of the 33 patients with CBD enrolled in this study, 85% showed granulomatous inflammation, and 97% had proliferation of BAL cells in response to beryllium salts. Thus, it is unlikely that the decreased sensitivity of the blood BeLPT is a result of misdiagnosis.…”

Section: Discussionsupporting

confidence: 72%

Frequency of beryllium-specific, T1-type cytokine-expressing CD4 T cells in patients with beryllium-induced disease

Pott¹,

Palmer²,

Sullivan³

et al. 2005

Journal of Allergy and Clinical Immunology

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Section: Discussionsupporting

confidence: 72%

Frequency of beryllium-specific, T1-type cytokine-expressing CD4 T cells in patients with beryllium-induced disease

Pott¹,

Palmer²,

Sullivan³

et al. 2005

Journal of Allergy and Clinical Immunology

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“…Interestingly, authors have found that the combination of elevated neopterin's serum levels with the conventional screening test for CBD, beryllium lymphocyte proliferation test exhibited an optimized positive predictive value suggesting neopterin as a valuable biomarker in discriminating workers with CBD from these that are only sensitized to beryllium rendering lung biopsy unnecessary. These results were substantiated by in-vitro studies of peripheral blood mononuclear cells derived by patients with CBD or beryllium exposed workers [90] and an association between serum levels of neopterin and clinicolaboratory parameters of the disease severity was found. However, further confirmatory tests in large cohorts of patients including serial measurements and correlation of results with clinical and radiological findings are essential to determine reliable cut-off values for the diagnosis of the disease and the assessment of the progression likelihood (Table 5).…”

Section: Serum Biomarkers In Occupational and Environmental Diseasmentioning

confidence: 76%

Serum biomarkers in interstitial lung diseases

et al. 2005

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The use of biomarkers in medicine lies in their ability to detect disease and support diagnostic and therapeutic decisions. New research and novel understanding of the molecular basis of the disease reveals an abundance of exciting new biomarkers who present a promise for use in the everyday clinical practice. The past fifteen years have seen the emergence of numerous clinical applications of several new molecules as biologic markers in the research field relevant to interstitial lung diseases (translational research). The scope of this review is to summarize the current state of knowledge about serum biomarkers in interstitial lung diseases and their potential value as prognostic and diagnostic tools and present some of the future perspectives and challenges.

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“…Various studies showed that neopterin can be used as a potential biomarker for immunity-related diseases such as rheumatoid arthritis, malignant processes, sarcoidosis, beriliosis, and interstitial pulmonary diseases [24,[27][28][29][30]. Tzouvelekis et al, 2005 showed the possible use of some serum biomarkers in patients with occupational and environment-related diseases [31].…”

Section: Discussionmentioning

confidence: 99%

Serum neopterin in workers exposed to inorganic dust containing free crystalline silicon dioxide

et al. 2009

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AbstractThe study was conducted among 92 male workers, divided into two groups depending on workplace and level of inorganic dust containing free crystalline SiO2 in the work environment, and 43 healthy workers without exposure to dust aerosols. The measured inhalable and respirable dust concentrations, as well as the concentration of free crystalline silica (FCS) in the respirable fraction were different for the two groups, but the percentage of free crystalline silica in the respirable fraction was almost identical. Significantly higher neopterin levels were found in workers exposed to dust, compared to the control group: 12.72 nmol/L and 6.32 nmol/L respectively (p<0.05). No significant difference was found between serum neopterin levels in both groups of the exposed workers. Among the groups with different length of service, a statistically higher neopterin level was evident only in the workers with length of service less than 10 years (p<0.05). The correlation analysis did not find a significant dependence of neopterin levels on the age of the studied workers or on the duration of smoking in packet years. The difference between neopterin levels in smokers and non-smokers was nonsignificant. The results obtained show that increased neopterin levels in the exposed workers are not influenced by individual features, duration and level of exposure to inorganic dust, but mostly by the presence of FCS in the respirable fraction.

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Beryllium‐stimulated neopterin as a diagnostic adjunct in chronic beryllium disease

Abstract: Neopterin may be a useful diagnostic adjunct in the non-invasive assessment of CBD, differentiating CBD from BeS. Further studies will be required to determine how it performs in workplace screening.

Cited by 12 publications

References 31 publications

Frequency of beryllium-specific, T1-type cytokine-expressing CD4 T cells in patients with beryllium-induced disease

Frequency of beryllium-specific, T1-type cytokine-expressing CD4 T cells in patients with beryllium-induced disease

Serum biomarkers in interstitial lung diseases

Serum neopterin in workers exposed to inorganic dust containing free crystalline silicon dioxide

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