Beryllium coordination chemistry

Synthesis and Structural Characterization of the Dinuclear Beryllium Species [Be2Cl2(μ-Cl)2(PCy3)2]

“…As berylliumcontaining materials feature unique properties, most of the corresponding research is done in material sciences [3]. With regard to its toxicity, additional work is focused on the coordination chemistry of Be(II) in aqueous solutions [4,5]. Thus, tetrahedral fourcoordinate Be species, which result from the coordination of ligands containing main group substituents, are well established [6 -10].…”

The bioinorganic chemistry and associated immunology of chronic beryllium disease

“…3 show how beryllium forms clusters in the presence of carboxylate, carbonate, hydroxo, oxo, alkoxide, and phenoxide ligands. 16,18,19 These chemical functionalities can be thought of as mimics for the amino acid residues aspartic and glutamic acid, tyrosine, serine, and threonine that are all present in the binding groove of HLA-DP. There are three possible scenarios for binding beryllium in the HLA-DP molecule: (1) beryllium serves alone as the antigen, and is a predominantly inorganic species, (2) beryllium is bound to a peptide fragment resulting from a previous beryllium-protein interaction, and (3) beryllium is not part of the antigen, but binds adjacent to the binding groove, changing its shape, and allowing the antigenic peptide to bind.…”

“…33,34 Even in the presence of excellent chelating ligands such as DHBA, beryllium precipitates in the presence of a phosphate buffer. The first stable beryllium complex isolated within a phosphate medium was (NH 4 ) 18 [Al 6 Be 6 (CA) 6 (PO 4 ) 8 ] based on the Be 2 Al 2 CA 4 complex. The phosphate complex is highly soluble at pH 7 (>1 M), stable in the presence of phosphate media (0.5 M), and has been characterized by X-ray diffraction.…”

Stable, Soluble Beryllium Aluminum Citrate Complexes Inspired by the Emerald Mineral Structure

“…[2,3] Most research has focused on the biological [4] and environmental [5] effects of beryllium with far less emphasis on the speciation and interactions of beryllium under physiological conditions. [6][7][8] The natural forms of beryllium, beryl and emerald, have not been reported to cause CBD unlike processed forms of beryllium metal and BeO. [9] The beryl structure [Be 3 Al 2 (SiO 3 ) 6 ] ( Figure 1) is interesting in two aspects: it has no Be-O-Be linkage despite the propensity of beryllium to form clusters and all of the beryllium-bound oxygen atoms are SiÀO units that bridge the aluminum and beryllium atoms.…”