Berufliche und außerberufliche Risikofaktoren für das Harnblasenkarzinom in einem ehemaligen Industriegebiet der neuen Bundesländer

Abstract

The overrepresentation of GSTM1 negative bladder cancer patients also in this industrialized area and more pronounced in several occupationally exposed subgroups points to an impact of the GSTM1 negative genotype in bladder carcinogenesis.

Re-assessment of the influence of polymorphisms of phase-II metabolic enzymes on renal cell cancer risk of trichloroethylene-exposed workers

“…Additional control groups (not diseased with cancer), in which the frequencies of genetic polymorphisms had been determined, were available from the areas of Dortmund (n = 236, SteinhoV et al 2000, control group extended) and of Lutherstadt Wittenberg (n = 209; Golka et al 2005, control group extended), totalling 445. These additional groups were used together with the original controls of Brüning et al (2003) for a second comparison of allele frequencies between the renal cell cancer cases of the study of Brüning et al (2003) and these combined control groups, resulting in the higher number of 770 controls.…”

Associations of GSTM1*0 and GSTA1*Agenotypes with the risk of cardiovascular death among hemodialyses patients

“…GSTA1 protein belongs to the most promiscuous GSTs that acts upon a broad range of substrates which bind to its active site [31-33]. However, conjugation with GSH by means of GST enzymes sometimes results in the formation of more reactive compounds [34-36]. It may be speculated that some of the accumulated uremic toxins is converted into more reactive intermediates by GSTA1 protein.…”