Bertholletia excelsa Seeds Reduce Anxiety-Like Behavior, Lipids, and Overweight in Mice

Frausto-González, Oswaldo; Bautista, Claudia J.; Narváez-González, Fernando; Hernandez-Leon, Alberto; Estrada‐Camarena, Erika; Rivero-Cruz, J. Fausto; González-Trujano, María Eva

doi:10.3390/molecules26113212

Cited by 4 publications

(6 citation statements)

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“…Regarding medicinal plants and their bioactive metabolites, a non-polar fraction of Tilia americana containing the terpene beta-sitosterol and a mixture of fatty acids produced anxiolytic-like effects in rodents [12]. In agreement with this report, a non-polar fraction of Bertholletia excelsa seeds, highly enriched with oleic acid (59.97%) and palmitic acid (21.42%), also produced significant anxiolytic-like effects in mice [10]. All these data together suggest that natural products are a source of several fatty acids with possible anxiolytic properties [13].…”

Section: Introductionsupporting

confidence: 86%

“…A meta-analysis reported that polyunsaturated fatty acids, such as Omega-3, produced anxiolytic effects in humans [8]. Similarly, preclinical studies had shown reduced anxiety-like behavior when rodents were treated with a mixture of long-chain saturated fatty acids [9][10][11]. Regarding medicinal plants and their bioactive metabolites, a non-polar fraction of Tilia americana containing the terpene beta-sitosterol and a mixture of fatty acids produced anxiolytic-like effects in rodents [12].…”

Section: Introductionmentioning

confidence: 99%

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Anxiolytic-like Effects and Quantitative EEG Profile of Palmitone Induces Responses Like Buspirone Rather Than Diazepam as Clinical Drugs

et al. 2023

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Anxiety is a mental disorder with a growing worldwide incidence due to the SARS-CoV-2 virus pandemic. Pharmacological therapy includes drugs such as benzodiazepines (BDZs) or azapirones like buspirone (BUSP) or analogs, which unfortunately produce severe adverse effects or no immediate response, respectively. Medicinal plants or their bioactive metabolites are a shared global alternative to treat anxiety. Palmitone is one active compound isolated from Annona species due to its tranquilizing activity. However, its influence on neural activity and possible mechanism of action are unknown. In this study, an electroencephalographic (EEG) spectral power analysis was used to corroborate its depressant activity in comparison with the anxiolytic-like effects of reference drugs such as diazepam (DZP, 1 mg/kg) and BUSP (4 mg/kg) or 8-OH-DPAT (1 mg/kg), alone or in the presence of the GABAA (picrotoxin, PTX, 1 mg/kg) or serotonin 5-HT1A receptor antagonists (WAY100634, WAY, 1 mg/kg). The anxiolytic-like activity was assayed using the behavioral response of mice employing open-field, hole-board, and plus-maze tests. EEG activity was registered in both the frontal and parietal cortex, performing a 10 min baseline and 30 min recording after the treatments. As a result, anxiety-like behavior was significantly decreased in mice administered with palmitone, DZP, BUSP, or 8-OH-DPAT. The effect of palmitone was equivalent to that produced by 5-HT1A receptor agonists but 50% less effective than DZP. The presence of PTX and WAY prevented the anxiolytic-like response of DZP and 8-OH-DPAT, respectively. Whereas only the antagonist of the 5-HT1A receptor (WAY) inhibited the palmitone effects. Palmitone and BUSP exhibited similar changes in the relative power bands after the spectral power analysis. This response was different to the changes induced by DZP. In conclusion, brain electrical activity was associated with the anxiolytic-like effects of palmitone implying a serotoninergic rather than a GABAergic mechanism of action.

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Section: Introductionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Anxiolytic-like Effects and Quantitative EEG Profile of Palmitone Induces Responses Like Buspirone Rather Than Diazepam as Clinical Drugs

et al. 2023

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“…This study showed that HDL‐c levels were increased in the supplemented groups, which might be due to high content (approximately 75%) of unsaturated fatty acids in BN because polyunsaturated fatty acids can decrease Apo B levels, whereas monounsaturated fatty acids can increase Apo A1 levels, a protein involved in lipid metabolism (Silva Figueiredo et al, 2017). BN, a source of omega‐3, could modulate antioxidant and anti‐atherosclerotic pathways, as animals supplemented with this nut showed decreased lipid peroxidation and improved lipid profile, represented by higher levels of HDL‐c (Balakrishnan et al, 2019; Carracedo et al, 2019; Frausto‐Gonzalez et al, 2021). Previous data on BN supplementation also found similar results of HDL‐c levels.…”

Section: Discussionmentioning

confidence: 99%

“…This study showed that the supplemented groups exhibited different responses of adipose tissue parameters; the BN5 group showed an increase in diameter and decrease in density of adipocytes, whereas the BN10 group showed a decrease in diameter and an increase in density. Frausto‐Gonzalez et al (2021) administered BN extracts for 40 days to Swiss‐Webster mice fed a hypercaloric diet, and they observed EAT modulation, indicated by a reduced adipocyte area in these animals.…”

Section: Discussionmentioning

confidence: 99%

Supplementation of diet with Brazil nut modulates body composition, bone parameters, and lipid peroxidation in Wistar rats

Costa

Almeida

Cruz

et al. 2022

Journal of Food Biochemistry

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Oxidative stress, adipose tissue, and bone compartments can be disturbed in chronic diseases. Non‐pharmacological strategies, such as Brazil nuts (BNs), can improve these parameters. This study evaluated the effects of BN supplementation at different concentrations on body composition, lipid profile, and peroxidation in healthy rats. Male Wistar rats were divided into three groups: control (CT), Brazil nut 5% (BN5), and Brazil nut 10% (BN10) groups. Body composition, brown adipose tissue (BAT), plasma lipid peroxidation, and lipid profile were evaluated in the three groups. The BN5 group showed an improvement in all bone parameters compared with that of the CT group (p < .0001). The BN5 and BN10 groups showed reduced plasma lipid peroxidation compared with that of the CT group (p = .0009), whereas the BN10 group presented lower BAT lipid peroxidation than that of the other groups (p = .01). High‐density lipoprotein‐cholesterol (HDL‐c) levels were higher in the BN5 group than in the CT group (p = .01). Conclusively, the use of BNs in a controlled manner promoted improvement in bone parameters, HDL‐c levels, and lipid peroxidation in healthy rats. Practical applications Nuts has been included in the diet because of their versatility, acceptance, and easy access. Among them, Brazil nut (BN) is considered one of the major known food sources of selenium as well as a source of fibers, unsaturated fatty acids, and phenolic compounds. Studies have shown that BN supplementation is effective in reducing oxidative stress, inflammation, lipid peroxidation, and selenium deficiency when used as a non‐pharmacological strategy in experimental models of chronic diseases and in clinical trials. The present study showed that controlled administration of BN improved bone parameters, high‐density lipoprotein‐cholesterol levels, and lipid peroxidation in healthy rats. Therefore, BN is a promising non‐pharmacological agent for the prevention of the onset of chronic non‐communicable diseases.

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“…In addition, we performed ROC analysis to compare HAMA and TC as factors that distinguish suicidal and non-suicidal individuals. Overweight and obesity have been reported as risk factors for anxiety 37 .…”

Section: Socio-demographic and Clinical Characteristicsmentioning

confidence: 99%

Prevalence and risk factors for suicide attempts in first episode and drug naïve major depressive disorder patients with overweight and obesity

Yan

et al. 2022

Preprint

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Depression and obesity are both risk factors for suicide attempts; however, the pattern of suicide attempts in individuals with major depressive disorder (MDD) who are overweight or obese remains uncertain. The purpose of this study was to examine the prevalence and risk variables for suicide attempts in first-episode and drug-naïve (FEND) MDD patients with overweight and obesity. This study included a total of 1026 FEDN MDD individuals who were overweight or obese. Their demographic data and metabolic parameters were collected. To examine the patients' symptoms, researchers employed the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS). The prevalence of suicide attempts in MDD patients with overweight and obesity was 19.59%. Among overweight and obese MDD patients, those with suicide attempts had significantly higher HAMD, HAMA, and PANSS positive symptom scores, as well as blood total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels than those without suicide attempts. Binary logistic regression analysis revealed that gender, BMI, HAMA, and TC were significantly associated with suicide attempts in MDD patients who were overweight or obese. Suicide attempters and non-suicide attempters could be distinguished by HAMA and TC by the receiver operating characteristic curve (ROC). The prevalence of suicide attempts is high in MDD patients with overweight and obesity. Some clinical parameters and metabolic parameters are correlates of suicide attempts in overweight and obese MDD patients.

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Bertholletia excelsa Seeds Reduce Anxiety-Like Behavior, Lipids, and Overweight in Mice

Cited by 4 publications

References 60 publications

Anxiolytic-like Effects and Quantitative EEG Profile of Palmitone Induces Responses Like Buspirone Rather Than Diazepam as Clinical Drugs

Anxiolytic-like Effects and Quantitative EEG Profile of Palmitone Induces Responses Like Buspirone Rather Than Diazepam as Clinical Drugs

Supplementation of diet with Brazil nut modulates body composition, bone parameters, and lipid peroxidation in Wistar rats

Prevalence and risk factors for suicide attempts in first episode and drug naïve major depressive disorder patients with overweight and obesity

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