Beriberi Induced Cardiomyopathy Requiring Salvage Venoarterial Extracorporeal Membrane Oxygenation

Shah, Aditya; Patel, Samir R.; Kothari, Sorabh; Denk, J

doi:10.1155/2016/5043818

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…Currently, the diagnosis of thiamine deficiency CM is by exclusion. Definitive diagnosis rests on three main factors: (i) the identification of clinical symptoms related to HF and characteristic history of dietary inadequacy in combination with excessive alcohol intake; (ii) the exclusion of other known aetiologies of heart disease; and (iii) a positive therapeutic response to pharmacological thiamine repletion [70,71]. Although the diagnostic process appears to be straightforward, it is frequently difficult to draw a definitive conclusion of thiamine deficiency CM because clinical manifestations are not usually pathognomonic [72,73].…”

Section: Micronutrients Deficiency Associated With Cardiomyopathymentioning

confidence: 99%

“…The non-toxic nature of thiamine even at high blood levels supports the approach of thiamine repletion as a therapeutic trial [71]. Moreover, there is virtually no downside to empiric treatment in thiamine deficiency patients with normal renal function since kidneys can rapidly eliminate excess thiamine [70] Carnitine deficiency: Carnitine (also known as beta-hydroxygamma-trimethylaminobutyric acid) is a naturally occurring hydrophilic amino acid derivative produced endogenously in the kidneys and liver or derived from meat and dairy products in the diet. Normal human omnivores (non-vegetarians) derive about 75% of carnitine from the diet while the rest is produced endogenously [77].…”

Section: Micronutrients Deficiency Associated With Cardiomyopathymentioning

confidence: 99%

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Nutritional deficiency cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management

Albakri¹

2019

Res Rev Insights

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The increasing recognition of deficiency of certain essential micronutrients in the failing heart suggests that they may be involved in the pathogenesis of nutritional deficiency cardiomyopathy (NDCM) and ultimately heart failure (HF). Chronic deficits in thiamine, carnitine, selenium, niacin, taurine and Coenzyme Q10 in the myocardial tissues have already been associated with alterations in myocardial energy production, calcium balance or oxidative defences. These pathologic changes may lead to metabolic or myocardial remodelling progressing into NDCM. Due to the severity of potential outcomes of untreated NDCM, it is important for cardiologists to have a good understanding of NDCM. More importantly, NDCM is a treatable phenotype of dilated or hypertrophic cardiomyopathy (CM). Early detection and prompt initiation of nutrient supplementation therapy (NST) has the potential to reverse pathologic myocardial changes and resolve cardiac symptoms. However, current expert consensus guidelines on the treatment of HF do not expressly recommend or are conspicuously silent about the use of NST possibly attributable to inconsistent findings by several small-scale trials and the lack of reliable data by large-scale randomized clinical trials. This review summarizes the existing published data about NDCM with an emphasis on the specific aetiologic micronutrients deficiencies, including their pathophysiology, manifestation, diagnosis and clinical management. This review also identifies gaps in current studies and areas of limited knowledge to move forward with research to fill these critical gaps in knowledge.

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Section: Micronutrients Deficiency Associated With Cardiomyopathymentioning

confidence: 99%

Section: Micronutrients Deficiency Associated With Cardiomyopathymentioning

confidence: 99%

Nutritional deficiency cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management

Albakri¹

2019

Res Rev Insights

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“…Parenteral thiamine supplementation is also recommended for high-risk patients such as ataxia, confusion and a history of chronic alcohol abuse [20]. The previous research confirms that intravenous thiamine administration resulted in improved cardiac function [21] and hemodynamic features [22,23], decreased systemic vascular resistance [24] or symptoms of heart failure [21]. Very high doses of thiamine, even 3 g/day, are used in the treatment of Alzheimer's disease [25].…”

Section: Introductionmentioning

confidence: 97%

The Changes in Antioxidant Activity of Selected Flavonoids and Caffeine Depending on the Dosage and Form of Thiamine

2021

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Phenolic compounds and thiamine may serve as therapies against oxidative stress-related neurodegenerative diseases. However, it is important to note that these components show high instability under changing conditions. The study’s aim was to determine the impact of the thiamine concentration (hydrochloride—TH and pyrophosphate—TP; in the range 0.02 to 20 mg/100 g on the indices of the chelating properties and reducing power, and free radicals scavenging indices of EGCG, EGC, ECG and caffeine added from 0.04 to 6.0 mg/100 g. Our research confirmed that higher concentrations of TH and TP can exhibit significant activity against the test antioxidant indices of all components. When above 5.0 mg/100 g of thiamine was used, the radical scavenging abilities of the compound decreased in the following order: EGCG > ECG > EGC > caffeine. The highest correlation was found for the concentration of thiamine pyrophosphate to 20.0 mg/100 g and EGCG. Knowledge of the impact of factors associated with the concentration of both EGCG, EGC, ECG or caffeine and thiamine on their activity could carry weight in regulating the quality supplemented foods, especially of nutrition support for people of all ages were oral, enteral tube feeding and parenteral nutrition).

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“…Vitamin C and B -complex are water soluble whereas Vitamin A, D, E and K are fat soluble dissolved in oil or in melted fat 11 . Thiamine (Vitamin B 1 ) is the trivial designation of a specific compound, 3-(4-amino-2-methylpyrimidin-5-ylmethyl)-5-(2hydroxyethyl)-4-methylthiazolium, which is sometimes also called vitamin B 1 and widely distributed in foods such as green beans, but most contain only low concentrations of the vitamin.The greatest concentrations of thiamine in grains are typically found in the scutellum (the thin layer between the germ and the endosperm) and the germ 3 .Thiaminehelps to prevent from heart disease 6 ,brain disorder 2 , neurological problems 4 , cures Beriberi 12 , renal disease 9 ,and diabetic peripheral neuropathy 14 .…”

Section: Introductionmentioning

confidence: 99%

Application of High Performance Thin Layer Chromatography-Densitometry and UV- Visible Spectrophotometry for the Simultaneous Determination of Thiamine in Green Beans

Asra¹,

Chandra²,

Zulharmita³

2018

IJCTR

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Two methods are described for the simultaneous determination of thiamine in green beans. The green beans were grinded and thiamine was extracted as bases into distilled water, separated by the first method, HPTLC silica gel 60 F 254 plate using methanol: water: acetic acid: ammonia (5:4.5:0.5:0.75) as mobile phase followed by densitometry measurement of its spot. The second method, a highly sensitive colour reaction has been developed. Thiamine was reacted with bromothymol blue to form an ion association complex in a weak base aqueous solution in the presence of some solubilization agents such as polyvinyl alcohol and analyzed by using UV-visible Spectrophotometry. The solution was measured at a maximum absorbance length of 430.5 nm. The first method showed that the detector response was linear for concentrations between 100-500 g/ml (r=0.998). The limits of detection and quantitation were 33.7 g/ml and 113.1 g/ml, respectively. The second method was found to offer good linearity (18-26 g/ml, r=0.998) with 0.6 g/ml limit of detection and 1.9 g/ml limit of quantitation. Thiamine contents from both methods were analyzed. The result showed that average contents of thiamine from both methods were 0.0396% and 1.0009%, respectively. The two proposed methods were successfully applied to the determination of thiamine in green beans.

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Beriberi Induced Cardiomyopathy Requiring Salvage Venoarterial Extracorporeal Membrane Oxygenation

Cited by 8 publications

References 8 publications

Nutritional deficiency cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management

Nutritional deficiency cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management

The Changes in Antioxidant Activity of Selected Flavonoids and Caffeine Depending on the Dosage and Form of Thiamine

Application of High Performance Thin Layer Chromatography-Densitometry and UV- Visible Spectrophotometry for the Simultaneous Determination of Thiamine in Green Beans

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