On 23 July, the World Health Organisation (WHO) declared the 2022 Monkeypox outbreak a 'Public Health Emergency of International Concern', following the rapid spread of infections in non-endemic countries (WHO, 2022a). The Monkeypox virus was first identified in 1970 and outbreaks are usually confined to West and Central Africa, although small numbers of cases traced to travel from these countries have been periodically reported elsewhere. Since May 2022, more than 71,000 confirmed cases have been reported in at least 107 countries globally, but principally in Europe and the USA (CDC, 2022; WHO, 2022b). Of the 71,096 confirmed cases globally, by 11 October 2022, only 719 cases were confirmed in the seven Central and West African countries where Monkeypox was endemic prior to 2022 (CDC, 2022).Unlike its usual epidemiology in Africa, most cases reported since May have been among gay, bisexual, and other men who have sex with men (GBMSM; WHO, 2022b). Here, I provide an overview of the current Monkeypox outbreak and the public health response to it, drawing out their geographical aspects. I argue geographers can contribute more nuanced understandings of the spatialities of GBMSM's changing socio-sexual networks capable of informing targeted and more equitable public health interventions. My empirical focus is on the response to Monkeypox in the United Kingdom (and, specifically, England), which is the fifth most affected country during the current outbreak (WHO, 2022b), but I do