Berberine regulates PADI4-related macrophage function to prevent lung cancer

Gu, Wenwen; Zhang, Mengdi; Gao, Fan; Niu, Yuji; Sun, Luyao; Xia, Haojie; Li, Wenwen; Zhang, Yaru; Guo, Zhenzhen; Du, Gangjun

doi:10.1016/j.intimp.2022.108965

Cited by 22 publications

(5 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PADI4 expression is directly correlated to the number of lung nodules in a murine model of lung cancer. By reducing PADI4 expression, berberine dose-dependently reduced lung nodules and improved lung function suggesting a putative tumor-preventative role of berberine ( 129 ). Inflammation, oxidative stress and intestinal flora imbalance are associated with colitis and colorectal cancer development and progression.…”

Section: Berberinementioning

confidence: 99%

Natural biomolecules and derivatives as anticancer immunomodulatory agents

Bernitsa

Dayan²,

Stephanou³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Despite advancements in chemotherapy, the issue of resistance and non-responsiveness to many chemotherapeutic drugs that are currently in clinical use still remains. Recently, cancer immunotherapy has gathered attention as a novel treatment against select cancers. Immunomodulation is also emerging as an effective strategy to improve efficacy. Natural phytochemicals, with known anticancer properties, been reported to mediate their effects by modulating both traditional cancer pathways and immunity. The mechanism of phytochemical mediated-immunomodulatory activity may be attributed to the remodeling of the tumor immunosuppressive microenvironment and the sensitization of the immune system. This allows for improved recognition and targeting of cancer cells by the immune system and synergy with chemotherapeutics. In this review, we will discuss several well-known plant-derived biomolecules and examine their potential as immunomodulators, and therefore, as novel immunotherapies for cancer treatment.

show abstract

Section: Berberinementioning

confidence: 99%

Natural biomolecules and derivatives as anticancer immunomodulatory agents

Bernitsa

Dayan²,

Stephanou³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…In lung cancer, the upregulation of PADI4 can inhibit the expression of IRF5 and CD86 and promote the expression of CD163 and CD206. This leads to the activation of macrophages and their pro-tumor effect, thereby promoting epithelial-mesenchymal transition (EMT) in lung cancer and inhibiting cell apoptosis ( 173 , 174 ).…”

Section: The Padi Family and Cancermentioning

confidence: 99%

Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review

2023

View full text Add to dashboard Cite

The peptidyl arginine deiminase (PADI) family is a calcium ion-dependent group of isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can serve as the target substrate of PADI family isozymes, and therefore, the PADI family is involved in NETosis and the secretion of inflammatory cytokines. Thus, the PADI family is associated with the development of inflammatory autoimmune diseases and cancer, reproductive development, and other related diseases. In this review, we systematically discuss the role of the PADI family in the pathogenesis of various diseases based on studies from the past decade to provide a reference for future research.

show abstract

“…Interestingly, berberine, an alkaloid from Rhizoma coptidis with diverse biological actions including anti-inflammatory and anti-tumor effects, was found to inhibit doxorubicin action on neutrophils and maintain the N1 phenotype, thus maintaining tumor cell sensitivity to doxorubicin [ 239 , 307 ]. Of note, berberine was also shown to regulate macrophage function in terms of cancer [ 308 ]. Tyagi et al found that nicotine polarizes neutrophils to the N2 phenotype via STAT3 activation.…”

Section: Neutrophil In Cancer Therapy: Potential Strategiesmentioning

confidence: 99%

Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies

Sounbuli

Миронова

Alekseeva

2022

IJMS

View full text Add to dashboard Cite

Neutrophils represent the most abundant cell type of leukocytes in the human blood and have been considered a vital player in the innate immune system and the first line of defense against invading pathogens. Recently, several studies showed that neutrophils play an active role in the immune response during cancer development. They exhibited both pro-oncogenic and anti-tumor activities under the influence of various mediators in the tumor microenvironment. Neutrophils can be divided into several subpopulations, thus contradicting the traditional concept of neutrophils as a homogeneous population with a specific function in the innate immunity and opening new horizons for cancer therapy. Despite the promising achievements in this field, a full understanding of tumor–neutrophil interplay is currently lacking. In this review, we try to summarize the current view on neutrophil heterogeneity in cancer, discuss the different communication pathways between tumors and neutrophils, and focus on the implementation of these new findings to develop promising neutrophil-based cancer therapies.

show abstract

Berberine regulates PADI4-related macrophage function to prevent lung cancer

Cited by 22 publications

References 49 publications

Natural biomolecules and derivatives as anticancer immunomodulatory agents

Natural biomolecules and derivatives as anticancer immunomodulatory agents

Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review

Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies

Contact Info

Product

Resources

About