BackgroundïŒLaminaria japonica has also been reported to have a therapeutic effect on AD, but the mechanism is not entirely clear. To explore the mechanism of Laminaria for the treatment of Alzheimer's disease (AD), the âactive components-targetsâ network and the protein-protein interaction (PPI) network were constructed for analyzing targetsâ functions and pathways. MethodsïŒThe main active components of Laminaria were extracted using the TCMSP database and were predicted and screened by GeneCards. Cytoscape was used to construct the âdrug-components-targets-diseaseâ network. STRING and Cytoscape were applied to map the PPI network. The Gene Ontology (GO) terms and KEGG pathways of targets were analyzed by Metascape. Results: Seven active components involving 23 active targets were obtained. The network analysis elucidated that Laminaria was mainly involved in cell process, metabolic process, response to stress and other biological processes. CASP3, PPARG, RELA, CCND1 and CASP9 played a key role in treating AD by regulating two small cell lung cancer and Toxoplasmosis. Conclusion: This study demonstrated that Laminaria could prevent and treat AD with advantages of multi-components, multi-targets and multi-pathways, which explored a new way for further research on the mechanism of Laminaria in the treatment of AD.