Berberine: New perspectives for old remedies

Tillhon, Micol; Ortiz, Luis Miguel Guamán; Lombardi, Paolo; Scovassi, Anna Ivana

doi:10.1016/j.bcp.2012.07.018

Cited by 383 publications

(291 citation statements)

References 92 publications

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“…For example, berberine, which is extracted from Coptis, has been shown to be a promising and potential therapy for the treatment of various types of diseases because of its diverse pharmacological characteristics, which include anti-microbial, anti-diabetic, anti-hyperlipidemic, anti-inflammatory and anti-oxidant properties [59][60][61] . Its protective effect against AS was recently discussed by Fan and colleagues [59] , who demonstrated that berberine treatment inhibited inflammatory reactions in J774A.1 cells by the induction of the autophagy process, which was mediated through the activation of the AMPK/mTOR signaling pathway.…”

Section: Pharmacological Intervention Of Autophagy In the Treatment Omentioning

confidence: 99%

The roles of macrophage autophagy in atherosclerosis

Shao

Han

Zeng³

et al. 2016

Acta Pharmacol Sin

180

116

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Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallmarks of atherosclerotic lesions. Consequently, the roles of macrophages in the pathophysiology of atherosclerosis are increasingly investigated. Autophagy is a self-protecting cellular catabolic pathway. Since its discovery, autophagy has been found to be associated with a variety of diseases, including cardiovascular diseases, malignant tumors, neurodegenerative diseases, and immune system disorders. Accumulating evidence demonstrates that autophagy plays an important role in inhibiting inflammation and apoptosis, and in promoting efferocytosis and cholesterol efflux. These facts suggest the induction of autophagy may be exploited as a potential strategy for the treatment of atherosclerosis. In this review we mainly discuss the relationship between macrophage autophagy and atherosclerosis and the molecular mechanisms, as well as the recent advances in targeting the process of autophagy to treat atherosclerosis.

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Section: Pharmacological Intervention Of Autophagy In the Treatment Omentioning

confidence: 99%

The roles of macrophage autophagy in atherosclerosis

Shao

Han

Zeng³

et al. 2016

Acta Pharmacol Sin

180

116

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“…Berberine has a significant potential to be a new drug for the treatment of many diseases, including cancer. Many research studies demonstrate that berberine inhibits tumor progression, decreases metastatic potential of malignant tumor and in combination with other drugs or radiation shows more effectiveness than the single therapy (Tillhon et al, 2012).…”

mentioning

confidence: 99%

Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis

Damjanović

Zdunić²,

Šavikin³

et al. 2016

Bangladesh J Pharmacol

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The cytotoxicity of Mahonia aquifolium ethanol and water extracts was examined using MTT test. The morphological changes were analyzed by fluorescence microscopy. Cell cycle distribution and possible activation of caspase-dependent pathway of cell death were assessed by flow cytometry. The effects of ethanol and water extracts on migration of endothelial EA.hy926 cells were analyzed by in vitro scratch assay and inhibition of angiogenesis was detected using tube formation assay. Both extracts demonstrated cytotoxic effects on cancer cell lines with very high selectivity. Morphological evaluation indicated apoptosis. These results were confirmed with cell cycle analysis, where there was accumulation of cancer cells in the subG1 phase. Ethanol and water extracts induced a caspase-dependent apoptosis in HeLa cells through activation of caspase-3 and caspase-8. Both extracts showed the ability to inbibit the migration of EA.hy926 cells and initial steps of angiogenesis. In addition, ethanol extract exerted significant anti-angiogenic effect.Video Clip:<a href="https://www.youtube.com/v/_b1LobagxyA">Cell seeding</a>: 2 min 26 sec<a href="https://www.youtube.com/v/LZrwdyvFAyI">4 hours after treatment of MTT-SDS applied</a>: 54 sec<a href="https://www.youtube.com/v/a6Dshdsg8TY">72 hours after treatment MTT applied</a>: 1 min 8 sec<a href="https://www.youtube.com/v/RE_SH-CauRU">Day 2 treatment</a>: 1 min 32 sec<a href="https://www.youtube.com/v/l4E1y0lgrAE">Measuring absorbance</a>: 9 sec

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“…Studies in the past decade suggest that TSN hits the model of "one-drug-multi-target-multi-disease, which is shared by" TCM, such as berberine [27]. Based on published literature and granted patents, we summarized the molecular targets of TSN in Table 2.…”

Section: Molecular Targets Of Tanshinone Ii-amentioning

confidence: 99%