Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung Cancer

Zhu, Ting; Li, Linlin; Xiao, Guangfa; Luo, Qizhi; Liu, Qiu-Zheng; Yao, Kangde; Xiao, Guang-Hui

doi:10.1142/s0192415x15500846

Cited by 65 publications

(42 citation statements)

References 27 publications

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“…Berberine also suppresses the invasive and metastasis of nasopharyngeal carcinoma (NPC) by inhibiting the activation of Signal Transducer and Activator of Transcription 3 (STAT3), a key mediator to trigger tumor-promoting inflammation [23]. The similar actions were observed in lung cancer, of which cell proliferation and tumor spheroid formation were suppressed by berberine [24]. Notably, berberine exhibits selective cytotoxicity against cancer cells instead of normal hepatocytes [25].…”

Section: Representative Anticancer Hcd Herbsmentioning

confidence: 99%

Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine

Zhang

Liang

2017

Chin Med

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In traditional Chinese medicine (TCM) theory, pathogenic heat and toxins, which are akin to the inflammatory factors, are the causes of cancer and could promote its virulent development. Therefore, heat-clearing and detoxicating (HCD) herbs are essential components of TCM formulas for cancer treatment. An increasing interest has been focused on the study of HCD herbs and accumulated evidences have shown that HCD herbs or HCD herbs-based formulas exhibited remarkable anticancer effects when used alone or combined with other therapeutic approaches. Some of the HCD herb-derived products have been tested in clinical trials. Studies revealed that extracts or pure compounds of the HCD herbs showed a broad anticancer spectrum against both solid and hematologic malignancies without significant toxic effects. Notably, some HCD herbs or formulas could strongly enhance the anticancer activities of chemo- or radio-therapy and alleviate their side effects. The anticancer activities of HCD herb exacts or the pure compounds were reported to be through multiple cellular or molecular mechanisms, such as induction of cancer cell apoptosis, differentiation and cell cycle arrest, inhibition of cancer cell growth, invasion and metastasis, and inhibition of tumor angiogenesis. In this review, we provide comprehensive analysis and summary of research progress and future prospects in this field to facilitate the further study and application of HCD herbs.

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Section: Representative Anticancer Hcd Herbsmentioning

confidence: 99%

Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine

Zhang

Liang

2017

Chin Med

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“…As berberine is also known for its action on STAT3, [12][13][14] the effect of berberine on STAT3 signaling was further explored. The Western blot analyses of STAT3 and pSTAT3 (tyrosine (Tyr) 705, and Ser 727) were performed in CCA cells treated with berberine in comparison with the control cells.…”

Section: Berberine Inhibited Growth Of Cca Cell Linesmentioning

confidence: 99%

Berberine Induces Cell Cycle Arrest in Cholangiocarcinoma Cell Lines <i>via</i> Inhibition of NF-κB and STAT3 Pathways

Puthdee

Seubwai

Vaeteewoottacharn

et al. 2017

Biological & Pharmaceutical Bulletin

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Berberine is a natural compound found in several herbs. Anticancer activity of berberine was reported in several cancers, however, little is known regarding the effects of berberine against cholangiocarcinoma (CCA). In this study, the growth inhibitory effects of berberine on CCA cell lines and its molecular mechanisms were explored. Cell growth and cell cycle distribution were examined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry. The expression levels of cell cycle regulatory proteins were determined by Western blot analysis. Berberine significantly inhibited growth of CCA cell lines in a dose and time dependent fashion. The inhibition was largely attributed to cell cycle arrest at the G1 phase through the reduction of cyclin D1, and cyclin E. Moreover, berberine could reduce the expression and activation of signal transducers and activator of transcription 3 (STAT3) and probably nuclear factor-kappaB (NF-κB) via suppression of extracellular signal-regulated kinase (ERK) 1/2 action. These results highlight the potential of berberine to be a multi-target agent for CCA treatment.

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“…Clinical studies have found that doxorubicin in combination with other chemotherapeutic drugs acts as a treatment for lung carcinoma (9). In general, the efficacy of chemotherapeutic drugs is limited in the treatment of lung cancer and the carcinoma cells may readily develop resistance to the drugs in clinical practice, significantly reducing the therapeutic efficacy of chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells

et al. 2015

Oncology Letters

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Abstract. Doxorubicin has been widely used in the treatment of cancer. However, acquired doxorubicin resistance severely hinders the application of the drug. In the present study, doxorubicin resistance was investigated in lung carcinoma. microRNA-155 (miR-155) was found to be upregulated in the doxorubicin-resistant A549/dox cell line. Suppression of miR-155 in this cell line considerably reversed doxorubicin resistance, and doxorubicin-induced apoptosis and cell cycle arrest were recovered. Furthermore, reverse transcription-polymerase chain reaction and western blot analysis revealed that miR-155 suppression downregulated the expression of multidrug resistance protein 1, multidrug resistance-associated protein 1, breast cancer resistance protein, glutathione S-transferase-π, Survivin and B-cell lymphoma 2, and upregulated the expression of caspase-3 and caspase-8. In addition, it was found that miR-155 suppression inhibited the activation of AKT and extracellular signal-regulated kinase. The transcriptional activity of nuclear factor-κB and activator protein-1 was also downregulated. In summary, the present results indicate that miR-155 may participate in doxorubicin resistance in lung carcinoma. The current study provides a novel target for lung carcinoma treatment.

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Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung Cancer

Cited by 65 publications

References 27 publications

Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine

Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine

Berberine Induces Cell Cycle Arrest in Cholangiocarcinoma Cell Lines <i>via</i> Inhibition of NF-κB and STAT3 Pathways

Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells

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