Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells

Xiong, Xinyu; Cheng, Zhe; Wu, Fan; Hu, Menglan; Liu, Zhimin; Dong, Ruolan; Chen, Guang

doi:10.1016/j.biopha.2020.111129

Cited by 30 publications

(24 citation statements)

References 42 publications

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“…TCM made of natural materials is considered superior to first-line clinical drugs for UC with fewer side effects ( Khan et al, 2019 ). TCM has immunomodulatory and anti-inflammatory effects in treating UC ( Sałaga et al, 2014 ; Xiong et al, 2021 ). Curcumin, the main active ingredient of the dried rhizome of Curcuma longa L. ( jiāng huáng ), has attracted much attention due to its potent anti-inflammatory effects.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of Probiotics Combined With Traditional Chinese Medicine for Ulcerative Colitis: A Systematic Review and Meta-Analysis

She

et al. 2022

Front. Pharmacol.

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Background: The combination of probiotics and traditional Chinese medicine (TCM) is a prospective therapy for ulcerative colitis (UC), and its efficacy and safety need to be urgently evaluated.Objective: This study aims to comprehensively assess the efficacy and safety of probiotics combined with TCM for the treatment of UC.Methods: The Pubmed, EMBASE, Cochrane library, China Academic Journals (CNKI), Wan-fang database, Chinese biomedical literature service system (CBM), and Chinese Science and Technology Journals (CQVIP) were searched. Subgroup analysis were designed in accordance with different control drugs, treatment courses, and types of probiotics. The Review Manager software (version 5.4.1) was utilized for statistical analysis.Results: 14 original studies containing 1,154 patients were analyzed and showed that probiotics with TCM was more effective than 5-aminosalicylic acid (5-ASA), probiotics or TCM used individually. Moreover, probiotics combined with TCM could inhibit the intestinal inflammation, reduce the recurrence rate and the incidence of adverse events. The subgroup analysis showed that a mixture of different probiotics was more effective than a single strain.Conclusion: It is suggested that probiotics combined with TCM could effectively control clinical symptoms, inhibit intestinal inflammatory response, and finally slow down the disease progress and reduce the disease recurrence with less adverse events. The mixture of different probiotics used in conjunction with individually tailored TCM is a potential clinical strategy for UC.

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Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of Probiotics Combined With Traditional Chinese Medicine for Ulcerative Colitis: A Systematic Review and Meta-Analysis

She

et al. 2022

Front. Pharmacol.

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“…Xiong et al have overviewed previous studies and concluded that berberine repairs intestinal barrier injury by promoting differentiation of intestinal stem cells through identifying bitter taste receptors on Tuft cells in ulcerative colitis. 80 Li et al have demonstrated that berberine restores the intestinal barrier homeostasis, maintains the residence of enteric glial cells, suppresses inflammatory cell infiltrations, and attenuates the overactivation of immune cells in mice with DSS-induced ulcerative colitis. 81 Jing et al have found that berberine improves intestinal barrier function by regulating intestinal microbiota-associated tryptophan metabolite and activating the aryl hydrocarbon receptor in rats with DSS-induced colitis.…”

Section: Introductionmentioning

confidence: 99%

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Wang¹,

Li²,

Wang³

et al. 2022

DDDT

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Intestinal barrier injury and hyperglycemia are common in patients with sepsis. Bacteria translocation and systemic inflammatory response caused by intestinal barrier injury play a significant role in sepsis occurrence and deterioration, while hyperglycemia is linked to adverse outcomes in sepsis. Previous studies have shown that hyperglycemia is an independent risk factor for intestinal barrier injury. Concurrently, increasing evidence has indicated that some anti-hyperglycemic agents not only improve intestinal barrier function but are also beneficial in managing sepsis-induced organ dysfunction. Therefore, we assume that these agents can block or reduce the severity of sepsis by improving intestinal barrier function. Accordingly, we explicated the connection between sepsis, intestinal barrier, and hyperglycemia, overviewed the evidence on improving intestinal barrier function and alleviating sepsis-induced organ dysfunction by anti-hyperglycemic agents (eg, metformin, peroxisome proliferators activated receptor-γ agonists, berberine, and curcumin), and summarized some common characteristics of these agents to provide a new perspective in the adjuvant treatment of sepsis.

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“…These compounds play roles in regulating cytokine concentrations and inflammation, restoring colon damage, and altering the gut. It has been shown that quercetin [ 29 ], luteolin [ 30 ], and berberine [ 31 ] suppress inflammatory damage in UC organoids; dietary kaempferol intake restores colon mucosal damage and inhibits MPO expression [ 32 ]; ß -sitosterol reduces weight loss, decreases proinflammatory factors, and resists pathogenic bacteria in UC mice [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Fructus mume pills (FMPs) have been clinically proven to be effective for treating ulcerative colitis (UC). However, the therapeutic and protective mechanisms have not been fully studied. Aim. We aimed to explore the mechanism of FMPs in an acetic acid (AA)-induced ulcerative colitis rat model. Methods. The targets, GO terms, and KEGG pathways for the FMPs and UC were screened and constructed using network pharmacology. A possible mechanism was verified in a 4% AA-induced colitis rat model. Colitis activity and state were evaluated using the disease activity index, and colon ulceration and intestinal mucosal damage were determined by histopathological observation through HE, AB-PAS, and Masson pathological staining. The concentrations of TNF-α, IL-6, IL-8, IL-10, MPO, MMP9, CXCR1, eNOS, and VEGF were measured to evaluate vascular permeability effects. Results. The network pharmacology results showed 108 active compounds, and 139 FMP-related targets were identified. Twenty-nine targets were identified for FMPs against UC, which included MMP9, MMP3, ESR1, PTGS1, PPARA, MPO, and NOS2. A total of 1,536 GO terms and 41 pathways were associated with FMP treatment of UC. The pharmacological evaluation showed that FMPs attenuated inflammation in AA-induced colitis by reducing the serum concentrations of TNF-α, IL-6, IL-8, and IL-10 and the colonic concentrations of MPO, MMP9, and CXCR1. FMPs ameliorated hyperpermeability by reducing the colonic VEGF and eNOS concentrations. FMPs also significantly decreased the VEGFA, VEGFR2, Src, and eNOS protein expressions in colon tissue through the VEGF-PI3K/Akt-eNOS signaling pathway. Conclusion. These results suggest that FMPs control UC inflammation by regulating inflammatory cytokine concentrations. FMPs alleviate AA-induced UC by regulating microvascular permeability through the VEGF-PI3K/Akt-eNOS signaling pathway.

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Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells

Cited by 30 publications

References 42 publications

Efficacy and Safety of Probiotics Combined With Traditional Chinese Medicine for Ulcerative Colitis: A Systematic Review and Meta-Analysis

Efficacy and Safety of Probiotics Combined With Traditional Chinese Medicine for Ulcerative Colitis: A Systematic Review and Meta-Analysis

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Mechanism of Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway

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