Berberine hydrochloride-loaded dung beetle chitosan/sodium alginate microspheres ameliorate DSS-induced colitis and regulate gut microorganisms in mice

Tang, Zhaoxia; Luo, Jiali; Faqir, Yahya; Zhang, Yu; Xue, Wenqian; Zhao, Hongmei; Jakhar, Ali Murad; Tan, Chengjia; Ma, Jiahua

doi:10.1016/j.ijbiomac.2023.128219

Cited by 1 publication

(1 citation statement)

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“…Currently, gut microbiome and their metabolites are the targets for the prevention and treatment of CRC by BBR. 43,49,67,68 BBR somewhat repairs the imbalance of gut microbiom induced by AOM/DSS, decreasing the richness of the microbial community due to its antibacterial properties 62,69 (Figure 1 and Table S1). BBR-induced fecal metabolic changes focused on regulating glucose metabolism, short-chain fatty acids metabolism, and amino acid metabolism.…”

Section: Bbr Regulates Gut Microbiome To Prevent and Treat Crcmentioning

confidence: 99%

Berberine: Potential preventive and therapeutic strategies for human colorectal cancer

Feng,

Lu,

Jiang

et al. 2024

Cell Biochemistry & Function

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Colorectal cancer (CRC) is a common digestive tract tumor, with incidences continuing to rise. Although modern medicine has extended the survival time of CRC patients, its adverse effects and the financial burden cannot be ignored. CRC is a multi‐step process and can be caused by the disturbance of gut microbiome and chronic inflammation's stimulation. Additionally, the presence of precancerous lesions is also a risk factor for CRC. Consequently, scientists are increasingly interested in identifying multi‐target, safe, and economical herbal medicine and natural products. This paper summarizes berberine's (BBR) regulatory mechanisms in the occurrence and development of CRC. The findings indicate that BBR regulates gut microbiome homeostasis and controls mucosal inflammation to prevent CRC. In the CRC stage, BBR inhibits cell proliferation, invasion, and metastasis, blocks the cell cycle, induces cell apoptosis, regulates cell metabolism, inhibits angiogenesis, and enhances chemosensitivity. BBR plays a role in the overall management of CRC. Therefore, using BBR as an adjunct to CRC prevention and treatment could become a future trend in oncology.

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