Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis

He, Yan; Yuan, Xiaoming; Zuo, Hao; Sun, Ying; Feng, Aiwen

doi:10.1159/000493412

Cited by 41 publications

(34 citation statements)

References 33 publications

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“…Finally, our results showing no extravasation in BRB-treated animals indicate that this natural compound may affect the angiogenic process without affecting vascular permeability during embryonic development, in line with results previously reported in VEGF-treated quail embryos 56 . In addition, results in vivo in rodents and in vitro in rat microvascular endothelial cells indicated that BRB may counteract vascular permeability 33,57,58 .…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, data on BBR effects on Cdh5 are very limited at present. BRB treatment has been reported to counteract the reduction of Cdh5 protein levels induced in vitro by lipopolysaccharide in rat intestinal microvascular endothelial cells 33 . In addition, the BRB-type natural alkaloid Coptisine inhibited the expression of Cdh5 in vitro in a human osteosarcoma cell line, at both mRNA and protein level 34 .…”

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confidence: 99%

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Exposure to the natural alkaloid Berberine affects cardiovascular system morphogenesis and functionality during zebrafish development

Martini

Pucci

Gabellini

et al. 2020

Sci Rep

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The plant-derived natural alkaloid berberine displays therapeutic potential to treat several pathological conditions, including dyslipidemias, diabetes and cardiovascular disorders. However, data on berberine effects during embryonic development are scarce and in part controversial. In this study, using zebrafish embryos as vertebrate experimental model, we address the effects of berberine treatment on cardiovascular system development and functionality. Starting from the observation that berberine induces developmental toxicity and pericardial edema in a time- and concentration-dependent manner, we found that treated embryos display cardiac looping defects and, at later stages, present an abnormal heart characterized by a stretched morphology and atrial endocardial/myocardial detachment. Furthermore, berberine affected cardiac functionality of the embryos, promoting bradycardia and reducing the cardiac output, the atrial shortening fraction percentage and the atrial stroke volume. We also found that, during development, berberine interferes with the angiogenic process, without altering vascular permeability. These alterations are associated with increased levels of vascular endothelial growth factor aa (vegfaa) mRNA, suggesting an important role for Vegfaa as mediator of berberine-induced cardiovascular defects. Altogether, these data indicate that berberine treatment during vertebrate development leads to an impairment of cardiovascular system morphogenesis and functionality, suggesting a note of caution in its use during pregnancy and lactation.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Exposure to the natural alkaloid Berberine affects cardiovascular system morphogenesis and functionality during zebrafish development

Martini

Pucci

Gabellini

et al. 2020

Sci Rep

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“…Intestinal vascular endothelial cells are important part of the intestinal mucosa. Different connexins are the key factors to maintain the stability of endothelial cells and maintain the permeability of the intestine [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

YQFM Alleviates Side Effects Caused by Dasatinib through the ROCK/MLC Pathway in Mice

Liu

Dai

Han

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Dasatinib, as a second-generation broad-spectrum tyrosine kinase inhibitor, presents an antitumor effect by inhibiting tyrosine kinases. However, dasatinib causes serious side effects, such as gastrointestinal bleeding and liver toxicity, possibly through the activation of ROCK kinase and MLC phosphorylation. At present, there is no effective prevention and treatment method. Previous research studies have shown that YQFM (YiQiFuMai powder injection) protects the blood-brain barrier by inhibiting the ROCK/MLC signaling pathway; whether YQFM can alleviate the side effects of dasatinib is unknown. In this study, dasatinib was injected (i.p. 70 mg/kg) and YQFM (i.p. 0.336 g/kg, 0.672 g/kg, 1.342 g/kg) was given in advance for 3 days to mice, to explore the effect of YQFM on side effects induced by Dasatinib. The results confirmed that YQFM significantly decreased Evans blue leakage in the small intestine and increased intestinal blood flow, increased the expression of ZO-1, Occludin, and VE-cadherin, and reduced the contents of D-lactic acid, s-VE-cadherin, Alanine aminotransferase (ALT), and Aspartate aminotransferase (AST) in serum. Finally, YQFM inhibited the expression of ROCK-1 and phosphorylation of MLC induced by Dasatinib. These findings suggested that YQFM could improve the side effects caused by Dasatinib linked with the ROCK/MLC signaling pathway, as shown in the graphical abstract.

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“…Berberine is an alkaloid extracted from the root and bark of Rhizoma coptidis and Cortex phellodendri and is known for its remedial properties in bacterial infections and gastrointestinal disorders 17,18 . Berberine has been shown to have anti‐inflammatory properties and has drawn attention as an agent for the treatment of sepsis.…”

Section: Treatment Of Sepsis With Polyphenolic Compoundsmentioning

confidence: 99%

The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

et al. 2020

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Sepsis and septic shock are still a leading cause of mortality and morbidity in intensive care units worldwide. Sepsis is an uncontrolled and excessive response of the innate immune system toward the invading infectious microbes, characterized by the hyper‐production of pro‐inflammatory mediators such as interleukin (IL)‐1β, IL‐6, tumor‐necrosis factor (TNF)‐α, and high‐mobility group box 1 (HMGB1). In severe sepsis, the overwhelming production of pro‐inflammatory cytokines and reactive oxygen species may compromise organ function and lead to the induction of abnormal apoptosis in different organs, resulting in multiple organ dysfunction syndrome and death. Hence, compounds that are able to attenuate inflammatory responses may have therapeutic potential for sepsis treatment. Understanding the pathophysiology and underlying molecular mechanisms of sepsis may provide useful insights in the discovery and development of new effective therapeutics. Therefore, numerous studies have invested much effort into elucidating the mechanisms involved with the onset and development of sepsis. The present review mainly focuses on the molecules and signaling pathways involved in the pathogenicity of sepsis. Additionally, several well‐known natural bioactive herbal compounds and phytochemicals, which have shown protective and therapeutic effects with regard to sepsis, as well as their mechanisms of action, are presented. This review suggests that these phytochemicals are able to attenuate the overwhelming inflammatory responses developed during sepsis by modulating different signaling pathways. Moreover, the anti‐inflammatory and cytoprotective activities of phytochemicals make them potent compounds to be included as complementary therapeutic agents in the diets of patients suffering from sepsis in an effort to alleviate sepsis and its life‐threatening complications, such as multi‐organ failure.

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Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis

Cited by 41 publications

References 33 publications

Exposure to the natural alkaloid Berberine affects cardiovascular system morphogenesis and functionality during zebrafish development

Exposure to the natural alkaloid Berberine affects cardiovascular system morphogenesis and functionality during zebrafish development

YQFM Alleviates Side Effects Caused by Dasatinib through the ROCK/MLC Pathway in Mice

The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

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