Berberine attenuates Aβ-induced neuronal damage through regulating miR-188/NOS1 in Alzheimer’s disease

Chen, Manman; Li, Lü; Liu, Chuanqin; Song, Lina

doi:10.1007/s11010-020-03852-1

Cited by 24 publications

(16 citation statements)

References 32 publications

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“…Detailed inspection of these functional groups further revealed enrichment of genes that are essential in nervous system development (Figure 4a,b). Several key promoters and regulators in central nervous system development (Nitric Oxide Synthase 1 (NOS1) [33][34][35][36]), neuron differentiation (T-box Transcription Factor 3 (TBX3) [37], Desmoplakin 3 (DPF3) [38,39], Bone Morphogenetic Protein 4 (BMP4) [37,40]) and neuronal development (Neurexin 2 (NRXN2) [41,42], Ataxin 1 (ATXN1) [43,44]) were upregulated, supporting neuronal differentiation [45] (Figure 4a,b). Additionally, there was also a prevalence of functional groups associated with cell division regulation including the mitotic cell cycle, nuclear division, regulation of metaphase/anaphase transition of the cell cycle, regulation of chromosome separation and spindle organization (Figure 3c,d).…”

Section: Gene Expression Profiles Characteristic Of Growth Arrest and Nervous System Development Are Induced By Sustained Low-dose Panobimentioning

confidence: 98%

Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy

Chong

Jayasekara

Vaghjiani

et al. 2021

Cancers

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Atypical teratoid rhabdoid tumour (ATRT) is a rare but highly aggressive undifferentiated solid tumour arising in the central nervous system and predominantly affecting infants and young children. ATRT is exclusively characterized by the inactivation of SMARCB1, a member of the SWI/SNF chromatin remodelling complex that is essential for the regulation of large sets of genes required for normal development and differentiation. Histone deacetylase inhibitors (HDACi) are a promising anticancer therapy and are able to mimic the normal acetylation functions of SMARCB1 in SMARCB1-deficient cells and drive multilineage differentiation in extracranial rhabdoid tumours. However, the potential efficacy of HDACi in ATRT is unknown. Here, we show that human ATRT cells are highly responsive to the HDACi panobinostat and that sustained treatment leads to growth arrest, increased cell senescence, decreased clonogenicity and induction of a neurogenesis gene-expression profile. Furthermore, in an orthotopic ATRT xenograft model, continuous panobinostat treatment inhibits tumour growth, increases survival and drives neuronal differentiation as shown by the expression of the neuronal marker, TUJ1. Collectively, this preclinical study supports the therapeutic potential of panobinostat-mediated differentiation therapy for ATRT.

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Section: Gene Expression Profiles Characteristic Of Growth Arrest and Nervous System Development Are Induced By Sustained Low-dose Panobimentioning

confidence: 98%

Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy

Chong

Jayasekara

Vaghjiani

et al. 2021

Cancers

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“…Additionally, osthole has pro-survival effects in APP-expressing neural stem cells through suppression of the Notch pathway (Li et al, 2017). Moreover, Berberine has been shown to enhance proliferation and attenuate neuron apoptosis via regulation of miR-188/NOS1 molecular cascade (Chen et al, 2020b). Treatment of Aβtreated murine microglia and neuroblastoma cells with this substance or upregulation of miR-188 in these cells has accelerated cell proliferation and suppressed caspase-3 activity and apoptosis (Chen et al, 2020b).…”

Section: Effects Of Herbal/chemical Agents On the Expression Of Mirnamentioning

confidence: 99%

“…Moreover, Berberine has been shown to enhance proliferation and attenuate neuron apoptosis via regulation of miR-188/NOS1 molecular cascade (Chen et al, 2020b). Treatment of Aβtreated murine microglia and neuroblastoma cells with this substance or upregulation of miR-188 in these cells has accelerated cell proliferation and suppressed caspase-3 activity and apoptosis (Chen et al, 2020b). Finally, exmedetomidine has been demonstrated to accomplish neuroprotective effects and enhance cognitive function in an animal model of AD by modulating the miR-129/YAP1/JAG1 cascade (Sun et al, 2020).…”

Section: Effects Of Herbal/chemical Agents On the Expression Of Mirnamentioning

confidence: 99%

The Eminent Role of microRNAs in the Pathogenesis of Alzheimer's Disease

Samadian

Gholipour

Hajiesmaeili

et al. 2021

Front. Aging Neurosci.

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Alzheimer's disease (AD) is an irrevocable neurodegenerative condition characterized by the presence of senile plaques comprising amassed β-amyloid peptides (Aβ) and neurofibrillary tangles mainly comprising extremely phosphorylated Tau proteins. Recent studies have emphasized the role of microRNAs (miRNAs) in the development of AD. A number of miRNAs, namely, miR-200a-3p, miR-195, miR-338-5p, miR-34a-5p, miR-125b-5p, miR-132, miR-384, miR-339-5p, miR-135b, miR-425-5p, and miR-339-5p, have been shown to participate in the development of AD through interacting with BACE1. Other miRNAs might affect the inflammatory responses in the course of AD. Aberrant expression of several miRNAs in the plasma samples of AD subjects has been shown to have the aptitude for differentiation of AD subjects from healthy subjects. Finally, a number of AD-modifying agents affect miRNA profile in cell cultures or animal models. We have performed a comprehensive search and summarized the obtained data about the function of miRNAs in AD in the current review article.

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“…The different 5'-UTRs of the multiple NOS1-mRNA isoforms (see above) are likely to regulate the translatability of these different NOS1 mRNAs [16]. Several miRNAs have been shown to directly [46][47][48][49][50][51] or indirectly [52] modulate human NOS1 expression.…”

Section: Post-transcriptional Regulation Of the Nos1 Expressionmentioning

confidence: 99%

Regulation of NOS expression in vascular diseases

2021

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Berberine attenuates Aβ-induced neuronal damage through regulating miR-188/NOS1 in Alzheimer’s disease

Cited by 24 publications

References 32 publications

Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy

Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy

The Eminent Role of microRNAs in the Pathogenesis of Alzheimer's Disease

Regulation of NOS expression in vascular diseases

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