Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels; evidences for oxidative stress and inflammation

Hassani-Bafrani, Hassan; Najaran, Hamed; Razi, Mazdak; Rashtbari, Hamid

doi:10.1111/and.13179

Cited by 32 publications

(28 citation statements)

References 67 publications

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“…This results support our hypothesis that BBR is able to mitigate Hg‐induced reproductive toxicity. Our results were in agreement with a previous study (Hassani‐Bafrani et al, 2019). It is reported that BBR administration restored the level of testosterone in response to varicocele‐induced testicular damage.…”

Section: Discussionsupporting

confidence: 94%

“…These findings suggest that antioxidant agents may inhibit LPO‐induced oxidative insult and the subsequent exacerbation of impairments associated with HgCl 2 ‐mediated testicular damage (Yin et al, 2019). BBR was shown to enhance the antioxidant response through scavenging ROS, preventing of LPO, and increasing gene and protein expression in the antioxidant defense system in different experimental models (Hassani‐Bafrani et al, 2019; Kazaz et al, 2019; Saleh et al, 2018). This results support our hypothesis that BBR is able to restrain Hg‐induced toxicity via its antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

“…BBR displays antioxidant properties in vitro, through the inhibition of reactive oxygen species (ROS) production, and in vivo, through enhancement of the cellular antioxidant molecules (Abdel Moneim, 2015; Kassab, Vasicek, Ciz, Lojek, & Perecko, 2017). BBR has been shown to inhibit oxidative insults in the testicular tissue in different experimental models through upregulating the expression of antioxidant defense system (Hassani‐Bafrani, Najaran, Razi, & Rashtbari, 2019; Saleh, Attia, & Ghareeb, 2018). Previous studies showed that BBR exerted anti‐inflammatory activities through the downregulation of pro‐inflammatory mediators (Kumar, Awasthi, Sharma, Padwad, & Sharma, 2020; Li et al, 2019; Zhao et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, BBR exhibited neuroprotective and hepatorenal protective activities (Abdel Moneim, 2015). Notably, BBR was found to protect the testicular tissue, improve sperm quality, and enhance spermatogenesis in different animal models (Hassani‐Bafrani et al, 2019; Rashtbari, Razi, Hassani‐Bafrani, & Najaran, 2018). Considering the antioxidant activity of BBR, we hypothesized that BBR is able to mitigate mercuric chloride (HgCl 2 ) toxicity.…”

Section: Introductionmentioning

confidence: 99%

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Berberine mitigates oxidative damage associated with testicular impairment following mercury chloride intoxication

2020

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In this study, we assessed the protective effect of berberine (BBR) against mercuric chloride (HgCl2)‐induced reproductive impairment. Twenty‐eight adult male Wistar albino rats were placed into four equal groups: control, BBR, HgCl2, and BBR + HgCl2. All the treatments were orally administered for seven consecutive days. The rats exposed to HgCl2 showed a marked decrease in testosterone accompanied by an increase in lipid peroxidation (LPO) and nitric oxide (NO). Additionally, HgCl2 decreased glutathione (GSH) content, deactivated catalase (CAT) and glutathione reductase (GR), and suppressed the activities and mRNA expression of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the testicular tissue. In addition, histological deformations and testicular cell loss were recorded, as evidenced by the upregulation of caspase‐3 following HgCl2 intoxication. Notably, BBR administration reversed the testicular impairments associated with HgCl2 exposure. These findings suggest that BBR protected the testicular tissue following HgCl2 exposure through inhibiting the disturbance in the testosterone level and enhanced the antioxidant capacity. Practical applications Heavy metals are naturally existing metallic elements in the earth’s crust. These trace metals have the potential to cause multiple adverse reactions to the living systems, even at low exposure doses. Human exposure may also result from industrial, agricultural, and domestic activities. Berberine (BBR, a naturally occurring quaternary benzylisoquinoline alkaloid) is a protoberberine and is the representative main active ingredient in all parts of Berberis species. BBR has been used widely in folk medicine worldwide for its multiple pharmacological and therapeutic activities; for example, in the treatment of digestive and reproductive system disorders, microorganism infections, hemorrhage and wound healing, and cardiovascular and ophthalmic diseases. We found that BBR administration was able to abrogate significantly the reproductive toxicity associated with Hg intoxication. This protective effect comes from its strong antioxidant, anti‐inflammatory, and antiapoptotic activities; suggesting that BBR may be applied to alleviate reproductive toxicity associated with Hg intoxication.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Berberine mitigates oxidative damage associated with testicular impairment following mercury chloride intoxication

2020

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“…71 In experimental varicocele, BBR as an antioxidant agent, promoted testicular antioxidant potential, promoted spermatogenesis, and upregulated the sperm quality. 72 A study showed that BBR protected PC-12 cells from oxidative injury by inhibiting ROS via PI3K/AKT/ mTOR signaling pathways. 73 In the pentylenetetrazoleinduced kindling model of epilepsy in rats, BBR exerted antioxidant properties and anti-epileptogenic effects by upregulating superoxide dismutase levels.…”

Section: Bbr's Antioxidant Activitiesmentioning

confidence: 99%

<p>The Anti-Cancer Mechanisms of Berberine: A Review</p>

Wang¹,

Liu²,

Du³

et al. 2020

CMAR

143

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Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related proteins and signaling pathways. In addition, BBR inhibits cell proliferation by interacting with microRNAs and suppressing telomerase activity. BBR exerts its anti-inflammation and antioxidant properties, and also regulates tumor microenvironment. This review emphasized that BBR as a potential antiinflammation and antioxidant agent, also as an effective immunomodulator, is expected to be widely used in clinic for cancer therapy.

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Lycopene protects sperm from oxidative stress in the experimental varicocele model

Babaei

Asadpour

Mansouri

et al. 2021

Food Science & Nutrition

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Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels; evidences for oxidative stress and inflammation

Cited by 32 publications

References 67 publications

Berberine mitigates oxidative damage associated with testicular impairment following mercury chloride intoxication

Berberine mitigates oxidative damage associated with testicular impairment following mercury chloride intoxication

<p>The Anti-Cancer Mechanisms of Berberine: A Review</p>

Lycopene protects sperm from oxidative stress in the experimental varicocele model

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