Berberine Alleviates Amyloid <i>β</i>-Induced Mitochondrial Dysfunction and Synaptic Loss

Zhao, Chunhui; Su, Ping; Lv, Chen; Guo, Limin; Cao, Guoqiong; Qin, Chunxia; Zhang, Wensheng

doi:10.1155/2019/7593608

Cited by 40 publications

(32 citation statements)

References 44 publications

(46 reference statements)

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“…In our next study, we plan to examine differences in gut microbiota in berberineand non-berberine treated mice as we hypothesize that these differences might be associated with differences in relapse propensity. Furthermore, a number of studies found that berberine has multifunctional properties and can inhibit the activity of important pathogenic enzymes, ameliorate intracellular oxidative stress, attenuate neuroinflammation, trigger autophagy, and protect neurons against recognition memory damage (de Oliveira et al, 2019;Yuan et al, 2019;Zhao et al, 2019). Undeniably, more research is needed to understand the effects of pre-extinction berberine intervention on relapse and uncover the underlying neurochemical and molecular mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Berberine Facilitates Extinction of Drug-Associated Behavior and Inhibits Reinstatement of Drug Seeking

et al. 2020

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A high rate of relapse is a major clinical problem among drug-addicted individuals. Persistent traces of drug-associated reward memories contribute to intense craving and often trigger relapse. A number of interventions on drug-associated memories have shown significant benefits in relapse prevention. Among them are pre-or post-extinction pharmacological manipulations that facilitate the extinction of drug-associated behavior. Berberine, a bioactive isoquinoline alkaloid, has been recently reported to provide therapeutic benefits for a number of central nervous system (CNS) disorders, including morphine addiction. The present study aimed to investigate whether berberine could serve as a post-extinction pharmacological intervention agent to reduce risks of reinstatement of drug seeking. We found that an intragastric administration of berberine at doses of 25 and 50 mg/kg during the critical time window significantly facilitated the extinction of morphine-reward related behavior in free access and confined conditioned place preference (CPP) extinction paradigms, and subsequently, it prevented reinstatement and spontaneous recovery of morphine-induced CPP in mice. Intriguingly, the berberine treatment with or without extinction training altered expression of plasticity-related proteins such as brain-derived neurotrophic factor (BDNF), AMPA receptors (GluA1 and GluA2) in the nucleus accumbens (NAc). Moreover, the post-extinction berberine treatment significantly reduced reinstatement of cocaine-induced CPP and operant intravenous self-administration (IVSA) memories in rats. Altogether, our findings suggest that extinction training combined with the postextinction berberine treatment can facilitate extinction of drug-associated behavior making it an attractive therapeutic candidate in relapse prevention.

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Section: Discussionmentioning

confidence: 99%

Berberine Facilitates Extinction of Drug-Associated Behavior and Inhibits Reinstatement of Drug Seeking

et al. 2020

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“…The study findings confirmed that berberine may preserve mitochondrial membrane potential, improve mitochondrial motility and prevent synaptic loss. 105 Caffeine is a naturally occurring CNS stimulant found in coffee, tea, and other plants. It has been used for medicinal purposes in many systems of traditional medicine for over thousands of years.…”

Section: Phytochemicalsmentioning

confidence: 99%

Bioactive Compounds and Traditional Herbal Medicine: Promising Approaches for the Treatment of Dementia

Alzobaidi¹,

Quasimi²,

Emad³

et al. 2021

DNND

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Dementia is a term that encompasses a group of clinical symptoms affecting memory, thinking and social abilities, characterized by progressive impairment of memory performance and cognitive functions. There are several factors involved in the pathogenesis and progression of dementia, such as old age, brain ischemia, toxin exposure, and oxidative stress. There are extensive similarities between dementia and Alzheimer's disease (AD) either in clinical manifestations or experimental animal models. AD is the most dominant form of dementia, characterized by the accumulation of beta-amyloid protein and cholinergic neurotransmission deficits in the brain. Currently available medications for the treatment of dementia, such as choline esterase inhibitors, N-methyl-D-aspartate (NMDA) antagonists (memantine), have short-term efficacy and only relieve symptoms rather than targeting the main underlying pathogenesis. Several animal studies and clinical trials are being conducted to provide a rational approach to these medicinal plants in the prevention or treatment of memory deficits. This review highlights the potential effects of medicinal plants and their derived lead molecules, and explains the related mechanisms and effects reviewed from published literature as major thrust aspects and hopeful strategies in the prevention or treatment of dementia.

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“…BBR exerts anti-platelet aggregation, stable plaque, and antiatherosclerotic effects Zhao et al, 2019).…”

Section: Berberine (Bbr)mentioning

confidence: 99%

Regulation of Mitochondrial Quality Control by Natural Drugs in the Treatment of Cardiovascular Diseases: Potential and Advantages

Chang

Zhang

Zhao

et al. 2020

Front. Cell Dev. Biol.

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Mitochondria are double-membraned cellular organelles that provide the required energy and metabolic intermediates to cardiomyocytes. Mitochondrial respiratory chain defects, structure abnormalities, and DNA mutations can affect the normal function of cardiomyocytes, causing an imbalance in intracellular calcium ion homeostasis, production of reactive oxygen species, and apoptosis. Mitochondrial quality control (MQC) is an important process that maintains mitochondrial homeostasis in cardiomyocytes and involves multi-level regulatory mechanisms, such as mitophagy, mitochondrial fission and fusion, mitochondrial energy metabolism, mitochondrial antioxidant system, and mitochondrial respiratory chain. Furthermore, MQC plays a role in the pathological mechanisms of various cardiovascular diseases (CVDs). In recent years, the regulatory effects of natural plants, drugs, and active ingredients on MQC in the context of CVDs have received significant attention. Effective active ingredients in natural drugs can influence the production of energy-supplying substances in the mitochondria, interfere with the expression of genes associated with mitochondrial energy requirements, and regulate various mechanisms of MQC modulation. Thus, these ingredients have therapeutic effects against CVDs. This review provides useful information about novel treatment options for CVDs and development of novel drugs targeting MQC.

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Berberine Alleviates Amyloid β-Induced Mitochondrial Dysfunction and Synaptic Loss

Cited by 40 publications

References 44 publications

Berberine Facilitates Extinction of Drug-Associated Behavior and Inhibits Reinstatement of Drug Seeking

Berberine Facilitates Extinction of Drug-Associated Behavior and Inhibits Reinstatement of Drug Seeking

Bioactive Compounds and Traditional Herbal Medicine: Promising Approaches for the Treatment of Dementia

Regulation of Mitochondrial Quality Control by Natural Drugs in the Treatment of Cardiovascular Diseases: Potential and Advantages

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