Berberine: A Promising Treatment for Neurodegenerative Diseases

Cheng, Ziqian; Kang, Chenglan; Che, Songtian; Su, Jingyun; Sun, Qihan; Ge, Tongtong; Guo, Yi; Lv, Jiayin; Sun, Zhihui; Yang, Wei; Li, Bingjin; Li, Xin; Cui, Ranji

doi:10.3389/fphar.2022.845591

Cited by 24 publications

(14 citation statements)

References 116 publications

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“…It has been reported to have broad antiviral activities against human immunodeficiency virus, dengue virus, zika virus, human cytomegalovirus, human papilomavirus, hepatitis C virus, chikungunya virus, human influenza virus, respiratory syncytial virus, herpes simplex virus, SARS-CoV-2, and enteroviruses ( Hayashi et al, 2007 ; Mahata et al, 2011 ; Song et al, 2014 ; Shin et al, 2015 ; Warowicka et al, 2020 ; Varghese et al, 2021 ). In addition, BBR has been shown to cross the blood-brain barrier efficiently and exhibited neuroprotective effects in many neurological disorders ( Kulkarni and Dhir, 2010 ; Cheng et al, 2022 ). Therefore, BBR may hold promising efficacy for neuronal injury caused by EV71 infection.…”

Section: Introductionmentioning

confidence: 99%

Berberine prevents lethal EV71 neurological infection in newborn mice

Cui

Wang²,

Yang³

et al. 2022

Front. Pharmacol.

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Enterovirus 71 (EV71) is the major pathogen causing fatal neurological complications of hand, foot, and mouth disease (HFMD) in young children. Currently no effective antiviral therapy is available. In the present study, we found that natural compound Berberine (BBR) displayed potent inhibitory effects on EV71 replication in various neural cells (IC50 of 2.79–4.03 μM). In a newborn mouse model of lethal EV71 infection, Berberine at 2–5 mg/kg markedly reduced mortality and clinical scores. Consistently, the replication of EV71 and pathological changes were attenuated in various infected organs including brain and lung with BBR treatment. Interestingly, EV71 infection in the brain mainly localized in the peripheral zone of brainstem and largely in astrocytes. Primary culture of astrocytes from newborn mouse brain confirmed the efficient EV71 replication that was mostly inhibited by BBR treatment at 5 μM. Further investigations revealed remarkably elevated cellular reactive oxygen species (ROS) levels that coincided with EV71 replication in primary cultured astrocytes and various cell lines. BBR largely abolished the virus-elevated ROS production and greatly diminished EV71 replication by up-regulating NFE2 like bZIP transcription factor 2 (Nrf2) via the kelch like ECH associated protein 1 (Keap)-Nrf2 axis. The nuclear localization of Nrf2 and expression of downstream antioxidant enzymes heme oxygenase 1 (HO-1) and NAD(P)H quinone dehydrogenase 1 (NQO1) were increased significantly by BBR treatment. Collectively, our findings revealed that BBR prevents lethal EV71 neurological infection via inhibiting virus replication through regulating Keap-Nrf2 axis and ROS generation in astrocytes of brainstem, thus providing a potential antiviral treatment for severe EV71 infection associated with neurological complications.

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Section: Introductionmentioning

confidence: 99%

Berberine prevents lethal EV71 neurological infection in newborn mice

Cui

Wang²,

Yang³

et al. 2022

Front. Pharmacol.

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“…Jiang et al reported that berberine is a safe and effective drug in patients with colorectal cancer and is beneficial in the treatment of these patients 20 . Similarly, human studies have shown that berberine is an effective agent in neurodegenerative disorders such as the Parkinson’s and Alzheimer’s diseases due to its potent antioxidant effect 21 . As oxidative stress is one of the most important steps in the underlying mechanism of NIHL, we predict that berberine can also be used for NIHL in humans with its strong antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of berberine on noise-induced hearing loss: a rat model

Kılıç

Sakat

Şahin

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Noise-induced hearing loss is a preventable form of hearing loss that has serious social and economic impacts. This study aimed to investigate the protective effect of berberine, a potent antioxidant and anti-inflammatory agent, against Noise-induced hearing loss. METHODS: After applying distortion product otoacoustic emission, 28 female Sprague-Dawley rats were randomly divided into four groups. Group 1 was designated as acoustic trauma group, and rats in this group were exposed to white noise for 12 h at an intensity of 4 kHz 110 dB sound pressure level. Group 2 was the control group. Group 3 was designated as the berberine group, and 100 mg/kg of berberine was administered to rats in this group by intragastric lavage for five consecutive days. Group 4 was designated as the acoustic trauma+berberine group. distortion product otoacoustic emission was repeated on the 6 th day of the study and cochlear tissues of rats were dissected for histopathological and immunohistochemical analyses after sacrificing rats. RESULTS: The distortion product otoacoustic emission results showed a significant decrease in signal-noise ratio values at higher frequencies in rats of the trauma group compared to those in other groups. Acoustic trauma caused severe histopathological impairment at cochlear structures together with severe 8-hydroxy-2-deoxyguanosine expression. Rats in the acoustic trauma+berberine group showed mild histopathological changes with mild 8-hydroxy-2-deoxyguanosine expression and better signal-noise ratio values. CONCLUSION: The histopathological and audiological findings of this experimental study showed that berberine provides protection in Noiseinduced hearing loss and may have the potential for use in acoustic trauma-related hearing losses.

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“…Berberine's small size allows it to effectively cross the blood-brain barrier, acting on a number of molecular targets. Many scholars [77][78][79] have found that berberine has broad potential in the treatment of neurodegenerative diseases. However, its benefits have only been discovered in recent years, so only a few studies have been performed on the subject.…”

Section: Coptidis Rhizomamentioning

confidence: 99%

Anti-Aging of the Nervous System and Related Neurodegenerative Diseases With Chinese Herbal Medicine

Du,

Lou,

et al. 2023

Am J Alzheimers Dis Other Demen

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Human beings have always pursued a prolonged lifespan, while the aging of the nervous system is associated with a large variety of diseases. Pathological aging of the nervous system results in a series of neurodegenerative diseases and can cause disability and death in the elderly. Therefore, there is an urgent need for the prevention and treatment of nervous system aging. Chinese herbal medicines have a long history, featuring rich and safe ingredients, and have great potential for the development of anti-aging treatment. We searched the publications on PubMed with key words “anti-aging of the nervous system” and “Chinese herbal medicine” in recent 10 years, and found sixteen Chinese herbal medicines. Then by comparing their popularity of use as well as active components based on the research articles, five common Chinese herbal medicines namely Ginseng Radix, Lycii Fructus, Astragali Radix, Coptidis Rhizoma and Ginkgo Folium, were confirmed to be the most related to anti-nervous system aging and neural degenerative diseases. At the same time, the active ingredients, research models, action mechanisms and curative effects of these five common Chinese herbal medicines were reviewed. From the five common Chinese herbal medicines reviewed in this paper, many encouraging effects of Chinese herbal medicines on treating nervous system aging and related diseases were revealed and more potent herbs would be explored with the help of the proposed possible mechanisms.

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Berberine: A Promising Treatment for Neurodegenerative Diseases

Cited by 24 publications

References 116 publications

Berberine prevents lethal EV71 neurological infection in newborn mice

Berberine prevents lethal EV71 neurological infection in newborn mice

The effectiveness of berberine on noise-induced hearing loss: a rat model

Anti-Aging of the Nervous System and Related Neurodegenerative Diseases With Chinese Herbal Medicine

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