Berberine, a potential prebiotic to indirectly promote Akkermansia growth through stimulating gut mucin secretion

Dong, Chunlan; Yu, Jiaqi; Yang, Yanan; Zhang, Fang; Su, Wenquan; Fan, Qin-hua; Wu, Chongming; Wu, Shan

doi:10.1016/j.biopha.2021.111595

Cited by 37 publications

(35 citation statements)

References 28 publications

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“…In line with those findings, replenishment with Akkermansia significantly reduced atherosclerosis induced by a high-fat diet by attenuating the aortic and systemic metabolic inflammatory response ( Li et al, 2016 ). A previous study revealed that BBR stimulated the gut bacteria-derived polyamines and enhanced mucin secretion in the colon of mice, exhibiting Akkermansia -promoting effects ( Dong et al, 2021 ). According to the study of Wu et al, the abundance of Alistipes , Allobaculum , Blautia , Roseburia , and Turicibacter were significantly increased, and the abundance of Bilophila was altered after BBR treatment.…”

Section: Berberine Reduced Atherosclerosis By Affecting Gut Microbiotamentioning

confidence: 99%

Atheroprotective Effects and Molecular Mechanism of Berberine

Xing

Zhou

Li³

et al. 2021

Front. Mol. Biosci.

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Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is the main pathological basis of cardiovascular diseases and it is closely associated with hyperlipidemia, endothelial injury, macrophage-derived foam cells formation, proliferation and migration of vascular smooth muscle cells (VSMCs), platelet aggregation, and altered gut microbiota. Various symptomatic treatments, that are currently used to inhibit atherosclerosis, need to be administered in long term and their adverse effects cannot be ignored. Berberine (BBR) has beneficial effects on atherosclerosis through regulating multiple aspects of its progression. This review highlights the recent advances in understanding the anti-atherosclerosis mechanism of BBR. BBR alleviated atherosclerosis by attenuation of dyslipidemia, correction of endothelial dysfunction, inhibition of macrophage inflammation and foam cell formation, activation of macrophage autophagy, regulation of the proliferation and migration of VSMCs, attenuation of platelet aggregation, and modulation of gut microbiota. This review would provide a modern scientific perspective to further understanding the molecular mechanism of BBR attenuating atherosclerosis and supply new ideas for atherosclerosis management.

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Section: Berberine Reduced Atherosclerosis By Affecting Gut Microbiotamentioning

confidence: 99%

Atheroprotective Effects and Molecular Mechanism of Berberine

Xing

Zhou

Li³

et al. 2021

Front. Mol. Biosci.

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“…An increase in the level of SCFAs in the stool was also noted [129]. The prebiotic effect of berberine has been demonstrated in numerous studies [130][131][132][133]. A previous study performed on obese mice have shown that berberine is more effective in modifying the structure of the microbiome than curcumin [131].…”

Section: Herbs and Spicesmentioning

confidence: 85%

“…in the cecum was correlated with an improvement in intestinal barrier function and a reduction in inflammation and oxidative stress indicators in the liver [131]. Berberine indirectly supports the growth of Akkermansia in mice by stimulating the secretion of intestinal mucin [132]. The use of berberine in diabetic rats resulted in an increase in the number of Bacteroidetes and Lactobacillaceae, and a decrease in the number of Proteobacteria and Verrucomicrobia [134].…”

Section: Herbs and Spicesmentioning

confidence: 97%

The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

et al. 2022

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Type 1 diabetes mellitus (T1DM) is a disease marked by oxidative stress, chronic inflammation, and the presence of autoantibodies. The gut microbiota has been shown to be involved in the alleviation of oxidative stress and inflammation as well as strengthening immunity, thus its’ possible involvement in the pathogenesis of T1DM has been highlighted. The goal of the present study is to analyze information on the relationship between the structure of the intestinal microbiome and the occurrence of T1DM. The modification of the intestinal microbiota can increase the proportion of SCFA-producing bacteria, which could in turn be effective in the prevention and/or treatment of T1DM. The increased daily intake of soluble and non-soluble fibers, as well as the inclusion of pro-biotics, prebiotics, herbs, spices, and teas that are sources of phytobiotics, in the diet, could be important in improving the composition and activity of the microbiota and thus in the prevention of metabolic disorders. Understanding how the microbiota interacts with immune cells to create immune tolerance could enable the development of new therapeutic strategies for T1DM and improve the quality of life of people with T1DM.

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“…Short chain fatty acids produced by gut microbiota have special physiological functions [ 35 ]. Akkermansia can use mucin as the sole source of carbon and nitrogen for energy metabolism [ 36 , 37 ]. It is also closely related to the body’s digestion and metabolism, can improve the metabolic status, and is considered a new type of probiotics.…”

Section: Discussionmentioning

confidence: 99%

Spore Powder of Paecilomyces hepiali Shapes Gut Microbiota to Relieve Exercise-Induced Fatigue in Mice

Guan

et al. 2022

Nutrients

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Paecilomyces hepiali, a fungal strain isolated from natural Ophiocordyceps sinensis, contains similar pharmacologically active components, has been used widely as a substitute of O. sinensis in functional food and medicine. However, the components and anti-fatigue effects of P.hepiali spores and their mechanisms of action are largely unknown. Here, we compared the chemical composition in P.hepiali spore (HPS) and mycelium (HPM) by liquid chromatography with tandem mass spectrometry analysis. We found 85 metabolites with significant differences, and HPS contains more L-Malic acid, Oxalacetic acid, Fructose-1,6-bisphosphate, and L-Arginine than HPM. Then we evaluated their anti-fatigue effects and regulatory effects on the gut microbiota in mice. The forced swimming time (SW) was only significantly increased in HPS groups: the high and low dose of the HPS group was 101% and 72% longer than the control group, respectively. Both HPS and HPM treatment decreased lactic acid, blood urea nitrogen, creatine kinase while increased lactate dehydrogenase (LDH) levels in the blood. Moreover, mice treated with HPS and HPM showed less skeletal muscle fiber spacing and breakage. The relative abundance of Alistips, Eubacterium, Bacterium, Parasutterella, and Olsenella in the gut microbiota of the HPS group was higher than that in the HPM group through 16S rRNA gene sequencing analysis. These changes may be related to the regulation of nucleotide, amino acid, and carbohydrate metabolism. Correlation analysis between the gut microbiota and fatigue-related indicators suggested that Alistips, Clostridium, Akkermansia, Olsenella, and Lactobacillus were positively correlated with the SW and LDH content. Our findings demonstrated that HPS has beneficial anti-fatigue effects by regulating gut microbiota.

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Berberine, a potential prebiotic to indirectly promote Akkermansia growth through stimulating gut mucin secretion

Cited by 37 publications

References 28 publications

Atheroprotective Effects and Molecular Mechanism of Berberine

Atheroprotective Effects and Molecular Mechanism of Berberine

The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

Spore Powder of Paecilomyces hepiali Shapes Gut Microbiota to Relieve Exercise-Induced Fatigue in Mice

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