Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation

Abstract

Inflammatory regulation induced by macrophage polarization is essential for cardiac repair after myocardial infarction (MI). Berberin (BBR) is an isoquinoline tetrasystemic alkaloid extracted from plants. This study analyzes the most likely mechanism of BBR in MI treatment determined via network pharmacology, showing that BBR acts mainly through inflammatory responses. Because platelets (PLTs) can be enriched in the infarcted myocardium, PLT membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles (BBR@PLGA@PLT NPs) are used, which show enrichment in the infarcted myocardium to deliver BBR sustainably. Compared with PLGA nanoparticles, BBR@PLGA@PLT NPs are more enriched in the infarcted myocardium and exhibit less uptake in the liver. On day three after MI, BBR@PLGA@PLT NPs administration significantly increases the number of repaired macrophages and decreases the number of inflammatory macrophages and apoptotic cells in infarcted rat myocardium. On the 28th day after MI, the BBR@PLGA@PLT group exhibits a protective effect on cardiac function, reduced cardiac collagen deposition, improved scar tissue stiffness, and an excellent angiogenesis effect. In addition, BBR@PLGA@PLT group has no significant impact on major organs either histologically or enzymologically. In summary, the therapeutic effect of BBR@PLGA@PLT NPs on MI is presented in detail from the perspective of the resolution of inflammation, and a new solution for MI treatment is proposed. Graphical Abstract

Enhancing breast cancer treatment: mesoporous dopamine nanoparticles in synergy with chrysin for photothermal therapy

“…It boasts a millennia-old history of utilization in traditional Chinese medicine ( 12 , 20 , 21 ). In the realm of traditional Chinese medicine, the treatment mechanisms of natural compounds are often intricate, involving complex networks when applied to patients ( 22 , 23 ). Confirming the primary mechanism by which Chrysin addresses breast cancer through quantitative animal experiments can be a formidable challenge.…”

Triptolide with hepatotoxicity and nephrotoxicity used in local delivery treatment of myocardial infarction by thermosensitive hydrogel

“…Weitong Lihua Laboratory Animal Center (Beijing, China) provided 200 g ± 10 g male rats for this study. The preparation of MI model was prepared as described previously [ 22 ]. Briefly, after the rat was anesthetized with 6 mg/kg sodium pentobarbital, the left anterior descending coronary artery (LAD) was ligated.…”

Advanced Nanomedicine Approaches for Myocardial Infarction Treatment

“…Furthermore, the NP group exhibits an enhanced cardiac function, reduced collagen deposition, as well as improved angiogenesis effect, indicating a potential solution for MI treatment. 98 Notoginsenoside R1 was also used to target inflammatory cells to improve heart repair after MI. 99 , 100 For instance, Qiu and coworkers synthesized arginyl-glycyl-aspartic acid (RGD) conjugated lipid-polymer hybrid nanoparticles (RGD-S/P-LPNs) loaded with salvianolic acid B (Sal B) and panax notoginsenoside (PNS).…”