“…For example, bradykinin induces eicosanoid formation in the airways, including prostaglandin E 2 , thromboxane, and 15-hydroxyeicosatetraenoic acid (Salari and Chan-Yeung, 1989;Arakawa et al, 1992). Prostanoids can both enhance and directly initiate coughing (Shinagawa et al, 2000;Liu et al, 2001;Xiang et al, 2002;Gatti et al, 2006;Maher et al, 2009;Ishiura et al, 2014). These effects of the bronchoconstrictor prostanoids could result from the activation of mechanically sensitive vagal afferent nerves innervating the airways and lungs (Bergren, 1997;Canning et al, 2001).…”