�ber Vorkommen und Bedeutung extra- und intracellul�rer periodisch geb�nderter filament�rer Assoziate

Nemetschek-Gansler, H.; Meinel, A.; Nemetschek, Th.

doi:10.1007/bf01102987

Cited by 16 publications

(3 citation statements)

References 26 publications

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“…Recent analysis of an experimental rabbit carcinoma has shown that, during tumour progression, pre-existing long collagen bundles are degraded into thick and wavy cords with frequent loss of cross-striation regularity (Strauli et al, 1983). Similar results have been described in skin carcinoma and in other human pathological conditions, where filamentous material showing a 100-nm pattern, has been observed and interpreted as lytic degradation of the collagen network (Nemetschek-Gansler et al, 1977;Van den Hooff and Tigchelaar-Gutter, 1983). Immunolocalization of collagenases has also been performed on malignant tissues (Woolley, 1982).…”

supporting

confidence: 80%

Ultrastructural evidence of collagenolytic activity in ductal infiltrating carcinoma of the human breast

Pucci‐Minafra

Luparello

Schillaci

et al. 1987

Intl Journal of Cancer

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The stroma of ductal infiltrating carcinoma of the human breast shows characteristic and localized areas of collagen rarefaction and fragmentation. This finding has been correlated with a peculiar type of fibrillar damage, observed in a small percentage of collagen fibrils isolated in the native state from the tumour stroma. The same pattern of lesion has been reproduced in vitro by human collagenase digestion on reconstituted fibrils. No effect has been detected by other nonspecific proteases in the same system.

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supporting

confidence: 80%

Ultrastructural evidence of collagenolytic activity in ductal infiltrating carcinoma of the human breast

Pucci‐Minafra

Luparello

Schillaci

et al. 1987

Intl Journal of Cancer

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“…The first proposition is more commonly accepted; we agree with it and believe that in our case active phagocytosis and digestion of collagen was taking place. Intracellular banded structures, also called long-spacing fibrils, banded filamentous associates, have been found in Morbus Dupuytren (Gokel & Hubner 1977, Nemetschek-Gansler et al 1977, in recurrent digital fibroma (Bhawan et al 1979), in chondrosarcoma (Imura et al 1975), in cultured tissue (Hentzner & Kobayasi 1979) etc. In some cases these bodies were located inside dilated cisternae connected with the endoplasmic reticulum of fibroblastic cells.…”

Section: Discussionmentioning

confidence: 99%

Multiple Cutaneous Fibromyxomas: a Light and Electron Microscopic Study

Zina

Bundino

1980

J Cutan Pathol

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A 27-year-old woman developed many nodular lesions, ranging in diameter from 3 mm to 15 mm and clinically indistinguishable from dermatofibromas. Light microscopic examination showed large amounts of mucin, fibroblasts and histiocytes throughout the dermis. Electron microscopic study revealed wide electron lucent areas and long branching winding electron dense threads occupying the ground substance. While dilated cisternae of endoplasmic reticulum containing a finely granular material characterized the fibroblasts, banded structures, intracellular collagen and myelinoid figures were prominent in the histiocytes. The term fibromyxoma is introduced to designate this tumor.

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“…We found intracellular fibers with a normal collagen banding pattern lying free within the cytoplasm of both degenerating and necrotic cells after thallium administration. Intracellular collagen fib e r s -w h e t h e r free, within vacuoles, or in lysosomes--have been described in many tissues of many species [36][37][38][39][40][41][42][43] and have been related to both synthesis and degradation.…”

Section: Bone Of Thallium-treated Chick Embryosmentioning

confidence: 99%

Thallium chondrodystrophy in chick embryos: Ultrastructural changes in the epiphyseal plate

Parker¹,

Scheck²

1981

Calcif Tissue Int

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Using the transmission electron microscope, we sought to describe the morphology of thallium sulfate-induced chondrodystrophy in chick embryos. There was cell death and degeneration in all zones of growth cartilage, but the cells and matrix of the hypertrophic zone were the most severely affected. Ultrastructural changes of the hypertrophic chondrocytes consisted of alteration of the cytoplasmic contents and of the intercellular matrix; the cell membrane was smooth and without cytoplasmic extensions. The cytoplasm was filled with dilated rough endoplasmic reticulum, vacuoles of varying sizes and contents, and lipidlike bodies with electron-dense granules; mineral crystals, collagen, and degenerating mitochondria were present. The matrix showed only spotty calcification and a reduced number of dense bodies, vesicles, and granules. The cells appeared to have failed to exteriorize cell products across the plasmalemma. Failure to exteriorize cell products and to form cytoplasmic processes reduced the number of potential nucleation sites for calcification. The ultrastructure of osteocytes was much less affected.

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�ber Vorkommen und Bedeutung extra- und intracellul�rer periodisch geb�nderter filament�rer Assoziate

Cited by 16 publications

References 26 publications

Ultrastructural evidence of collagenolytic activity in ductal infiltrating carcinoma of the human breast

Ultrastructural evidence of collagenolytic activity in ductal infiltrating carcinoma of the human breast

Multiple Cutaneous Fibromyxomas: a Light and Electron Microscopic Study

Thallium chondrodystrophy in chick embryos: Ultrastructural changes in the epiphyseal plate

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