�ber spasmolytische Wirkungen am Sphincter Oddi

Erdmann, W. D.; Henne, H. F.

doi:10.1007/bf00247197

Cited by 10 publications

(10 citation statements)

References 19 publications

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“…However, they also found an initial decrease in flow followed by an increase. Erdmann & Henne (1953) recorded an increase in sphincter tonus in the cat after the administration of noradrenaline and adrenaline. Dardik, Schein, Warren & Gliedman (1969) found a mixed response to noradrenaline on passage pressure in the sphincter of Oddi in dogs.…”

Section: Discussionmentioning

confidence: 99%

Adrenoceptors in the cat choledochoduodenal junction studiedin situ

Liedberg

Persson

1970

British J Pharmacology

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Summary1. The effects of adrenaline, noradrenaline, isoprenaline and terbutaline (PINN), 1-(3,5-dihydroxyphenyl)-2(t-butylamino)-ethanol, on the sphincter of Oddi were studied in anaesthetized cats. Both adrenaline and noradrenaline(1-A ,Lg/kg) increased resistance to flow through the sphincter. This effect was blocked by dibenamine (05-2-5 mg/kg) and by phenoxybenzamine (0O5-1-0 mg/kg).2. Isoprenaline (05-5O p0,g/kg) as well as terbutaline (0-5-10-0 jug/kg) inhibited the spontaneous sphincter activity and decreased flow resistance. In these doses, isoprenaline provoked marked tachycardia and relaxation of the duodenum, whereas the cardial and intestinal effects of terbutaline were minimal. The effects were blocked by propranolol (0O5-1-0 mg/kg). 3. The results confirm earlier observations of the presence of a-adrenoceptors active in contraction of the sphincter musculature and of p-adrenoceptors active in its relaxation. It is suggested that the /8-adrenoceptors belong to the 132 type according to Lands' classification.

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Section: Discussionmentioning

confidence: 99%

Adrenoceptors in the cat choledochoduodenal junction studiedin situ

Liedberg

Persson

1970

British J Pharmacology

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“…There have been contradictory reports about the action of sympathomimetic drugs on the smooth muscle at the junction of the bile duct and the duodenum (Oddi's sphincter). According to some authors these drugs induce a relaxation (Winkelstein & Aschner, 1924;Burget, 1925;Iwanga, 1925;Lueth, 1931 ;*Shi, 1933;Bergh, 1942;Lorenzini & Elzenbaum, 1952;Ishioka, 1959;Pasechnik, 1959;Stalport, Nicolas, Demelenne & Horeczki, 1959;Stille & Hilfiker, 1962), but others have reported differently (Reach, 1920;McWhorther, 1921 ;Lueth, 1931;Doubilet & Colp, 1937;Poilleux, Goidin & Nicolaidis, 1952;Erdmann & Henne, 1953;Taccani & Zaffagnini, 1953a, b;Fogliati, Ciocatto, Cattaneo & Giudice, 1954;Granser, Hertting, Rissel & Wewalka, 1956;Menguy, Hallenbeck, Bollman & Grindlay, 1958;Pasechnik, 1959).…”

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confidence: 99%

Actions of Sympathomimetic Drugs on the Smooth Muscle at the Junction of the Bile Duct and Duodenum Studied in Situ

Benzi¹,

Bertě²,

Crema³

et al. 1964

British Journal of Pharmacology and Chemotherapy

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The actions of adrenaline, noradrenaline, phenylephrine and isoprenaline have been examined on flow through the terminal bile duct and on the tone of the duodenum in the vicinity of the terminal bile duct. These drugs were injected intravenously, or intra-arterially into the blood supply of the junction of the bile duct and duodenum. The effects of the antagonistic drugs, dibenamine and dichloroisoprenaline, were also tested. Isoprenaline always relaxed the duodenum and increased the flow through the bile duct. Adrenaline, noradrenaline and phenylephrine relaxed the duodenum, but had variable effects on the flow through the bile duct. It is concluded that adrenaline acts directly on the smooth muscle of the bile duct to contract it, but the influence of the neighbouring duodenal muscle may nevertheless result in an increase in flow through the duct.There have been contradictory reports about the action of sympathomimetic drugs on the smooth muscle at the junction of the bile duct and the duodenum (Oddi's sphincter). According to some authors these drugs induce a relaxation

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“…ScHACTER and DvORKIN (1942) reported that bile salts do not enhance the actions of acetylcholine, and the characteristic depressor response seen following intravenous administration must be due to a mechanism other than the inhibition of cholinesterase. However, ERDMANN and HENNE (1954) demonstrated that certain bile acids do have anti-ChE effects on the intestine both in vitro and in vivo. They reported that desoxycholic acid was most active.…”

Section: Anticholinergic Drugsmentioning

confidence: 97%

Structure-Activity Relationships of the Reversible Anticholinesterase Agents

Long¹

1963

Cholinesterases and Anticholinesterase Agents

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�ber spasmolytische Wirkungen am Sphincter Oddi

Cited by 10 publications

References 19 publications

Adrenoceptors in the cat choledochoduodenal junction studiedin situ

Adrenoceptors in the cat choledochoduodenal junction studiedin situ

Actions of Sympathomimetic Drugs on the Smooth Muscle at the Junction of the Bile Duct and Duodenum Studied in Situ

Structure-Activity Relationships of the Reversible Anticholinesterase Agents

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