�ber kondensierte Heterocyclen aus ?-Isothiocyanatoketonen und Aminoalkoholen bzw. Diaminen

Cytotoxicity and anti-HIV evaluations of some new synthesized quinazoline and thioxopyrimidine derivatives using 4-(thiophen-2-yl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione as synthon

“…Infrared spectra were recorded on Carlzeise Spectrophotometer model "UR 10" spectrophotometer using the KBr disc technique. 1 H-NMR spectra were recorded on Varian Gemini 270 MHz spectrometer (DMSO-d 6 ) and the chemical shifts are given in δ (ppm) downfield from tetramethylsilane (TMS) as an internal standard. The mass spectra were measured using a Finnigan SSQ 7000 mass spectrometer.…”

“…The separated solid was collected by filtration, washed with water, dried and crystallized to give compound 7, in yield: 72%; mp: 115 • C (EtOH); IR (KBr) ν max : 3207 and 1661 cm −1 corresponding to ν(NH) and ν (C=O), respectively. 1…”

“…A mixture of compound 3 (2.98 g, 0.01 mol) and sodium hydride (0.8 g, 0.02 mol) in dimethylformamide (40 ml) was stirred at 70-80 • C for 1 h. then cooled to room temperature, chlorodiethyl ether (1 g, 0.01 mol) was added and heated at 90 • C for 5 h. The reaction mixture was evaporated under reduced pressure, the obtained residue was triturated with water and the obtained solid was filtered off, dried and crystallized to give compound 9 in yield: 72%; m.p: 220 • C (EtOH); IR (KBr) ν max : 3416 (NH), 1189 cm −1 (C=S); 1…”

“…A mixture of compound 3 (2.98 g, 0.01 mol), acetylchloride (0.78 g, 0.01 mol) in pyridine (30 ml) was refluxed for 2 h. The reaction mixture was poured onto acidified water (pH ∼ 3), the solid formed was filtered off, washed with water, dried and crystallized to give compound 11 in yield: 60%; m.p: 195 • C (AcOH); IR (KBr) ν max : 3257 and 1671 cm −1 corresponding to ν(NH) and ν(C=O, acetyl), respectively. 1…”

“…Analgesic, anti-arrhythmic, anticancer, antipyretic and anti-inflammatory activities are observed in some pyrimidinoyl and thioxopyrimidinoyl derivatives. [1][2][3][4][5] Also, in our previous work we prepared certain new substituted heterocyclic derivatives which exhibit analgesic, anti-inflammatory, antiparkinsonian, and androgenic-anabolic activities. [6][7][8][9][10][11] In addition, the heterocyclic nitrogen derivatives exhibited a general ionophoric potency for divalent cations 12 and used a novel thiocyanate-selective membrane sensor.…”