�ber k�rnchenhaltige Zellen im menschlichen und tierischen Endometrium (endometriale K�rnchenzellen, metachromasierende Zellen)

Hellweg, G

doi:10.1007/bf00338865

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…With the exception of the chinchilla (in which these cells were rare), they have not been found in the nonpregnant uteri of other mammals. Similar-appearing granulocytes do occur, however, in the pregnant uteri of many species (Baker, 1948;Hamper1 and Hellweg, 1958;Hellweg, 1959;Peel, 1977, 1978;Croy and Kassouf, 1989). In primates these cells frequently have been referred to as endometrial stroma1 granulocytes, although in the case of macaques some have also been observed in the superficial myometrium (Cardell et al, 1969).…”

Section: Discussionmentioning

confidence: 95%

Spontaneous decidual reactions and menstruation in the black mastiff bat, Molossus ater

Rasweiler

1991

Am. J. Anat.

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Uterine function was assessed histologically in nonpregnant Molossus ater removed from a laboratory breeding colony. During the luteal phase of the cycle, bilateral decidual reactions were found to develop spontaneously in the absence of either embryos or experimental manipulation of the uterus. These included the formation of early decidual giant cells, closure of the uterine lumina, and morphological changes in the endometrial blood vessels. Some endothelial cell hypertrophy was noted in much of the decidua, but this was most pronounced in vessels associated with an unusual vascular tuft that formed in the endometrium surrounding the cranial end of the uterine lumen. These latter vessels also developed very prominent basal laminae. In pregnant bats, this tuft played a central role in the morphogenesis of the definitive discoidal chorioallantoic placenta. At the end of nonpregnant cycles, the decidua became necrotic and was sloughed off with associated bleeding. As in menstruating catarrhine primates, the endometrium of M. ater is vascularized by spiral arterioles and populated by distinctive granulocytes containing large, acidophilic granules. Increased coiling of these arterioles did not appear to be an essential element in the mechanism of mensturation in this species. M. ater is a monotocous, seasonal breeder, with a relatively long gestation period. Although it has a bicornuate uterus, ovulation and implantation appear to occur only on the right side of the tract. The ability to menstruate probably affords this bat an efficient mechanism for eliminating a highly differentiated endometrium from the usual implantation site in the event of a reproductive failure. In the wild, this may provide M. ater with another chance to establish a pregnancy at a still opportune time during the same breeding season.

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Section: Discussionmentioning

confidence: 95%

Spontaneous decidual reactions and menstruation in the black mastiff bat, Molossus ater

Rasweiler

1991

Am. J. Anat.

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“…In his work, Hamperl mentions that similar cells—argentaffin (take up silver stain) macrophages named “Körnchenzellen”—were described in the inaugural dissertation of W. Dyx in 1941, but the work could not be accessed. In subsequent years, it was discovered that acidophil granulated cells located in the human endometrium and decidua had been observed many years ago by Marchand in 1904 [ 15 ] and Weill in 1921 [ 16 ], as mentioned by Hellweg in 1959 [ 17 ]. Hamperl initially preferred the name “F cells” or fluorocytes, due to the typical fluorescence of these granules in the frozen or paraffin tissue sections when exposed to UV light.…”

Section: Historical Overview Of the Uterine Natural Killer (Unk) Cell...mentioning

confidence: 99%

The Neglected Uterine NK Cells/Hamperl Cells/Endometrial Stromal Granular Cell, or K Cells: A Narrative Review from History through Histology and to Medical Education

Lapides

Varga

Csöbönyeiová

et al. 2023

IJMS

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Reproductive immunology is at the forefront of research interests, aiming to better understand the mechanisms of immune regulation during gestation. The relationship between the immune system and the implanting embryo is profound because the embryo is semi-allogenic but not targeted by the maternal immune system, as expected in graft-versus-host reactions. The most prominent cell population at the maternal–fetal interface is the population of uterine natural killer (uNK) cells. Uterine NK cells are two-faced immunologically active cells, bearing comparison with Janus, the ancient Roman god of beginnings and endings. Their first face can be seen as natural killer cells, namely lymphocytes, which are critical for host defense against viruses and tumors. Even though uNK cells contain cytolytic molecules, their cytotoxic effect is not applied to classical target cells in vivo, playing a permissive rather than a defensive role. Their second face is crucial in maintaining physiological gestation—uNK cells show critical immunomodulatory functions with the potential to control embryo implantation and trophoblast invasion, regulate placental vascular remodeling, and promote embryonic/fetal growth. Therefore, we believe that their current designation “natural killer cells” (the first “cytotoxic” Janus’s face) is misleading and inappropriate, considering their principal function is supporting and maintaining pregnancy. In this narrative review, we will focus on three lesser-known areas of knowledge about uNK cells. First, from the point of view of histology, we will comprehensively map the history of the discovery of these cells, as well as the current histological possibilities of their identification within the endometrium. To be brief, the discovery of uNK cells is generally attributed to Herwig Hamperl, one of the most influential and prominent representatives of German pathology in the 20th century, and his co-worker, Gisela Hellweg. Secondly, we will discuss the interesting aspect of terminology, since uNK cells are probably one of the human cells with the highest number of synonymous names, leading to significant discrepancies in their descriptions in scientific literature. From the first description of this cell type, they were referred to as endometrial granulocytes, granular endometrial stromal cells, or large granular lymphocytes until the end of the 1980s and the beginning of the 1990s of the last century, when the first publications appeared where the name “uterine NK cells” was used. The third area of present review is medical teaching of histology and clinical embryology. We can confirm that uNK cells are, in most textbooks, overlooked and almost forgotten cells despite their enormous importance. In the present narrative review, we summarize the lesser-known historical and terminological facts about uNK cells. We can state that within the textbooks of histology and embryology, this important cell population is still “overlooked and neglected” and is not given the same importance as in fields of clinical research and clinical practice.

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“…The chromatin frequently appears as coarse clumps distributed about the periphery of the nucleus. Previous work has indicated that EGC are numerous in the non-pregnant uteri only of animals that men¬ struate (Hellweg, 1959;Dallenbach-Hellweg, Dawson & Hisaw, 1966; J. J. Rasweiler IV Cardell, Hisaw & Dawson, 1969).…”

Section: The Basal Cellmentioning

confidence: 99%

The Basal or Indifferent Cell and the Ciliary Vacuole in the Oviducal Epithelium of the Long-Tongued Bat, Glossophaga Soricina

Rasweiler¹

1972

Reproduction

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New observations have been made on the origins of the basal or indifferent cell and the ciliary vacuole or`Flimmerblase' in the oviducal epithelium. Initially, the basal cells possess metachromatic granules and are Alcian blue-positive. It is proposed that they arise primarily from connective tissue mast cells which migrate into the epithelium and undergo degranulation. Their ultimate fate appears to be to dissolve within the epithelium. Evidence against their function as a precursor cell for the ciliated and secretory cells is presented.Ciliary vacuoles appear to develop from spaces left primarily by eosinophilic leucocytes and/or mast cells which have migrated into the epithelium and undergone dissolution. Cilia then grow into the spaces.

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�ber k�rnchenhaltige Zellen im menschlichen und tierischen Endometrium (endometriale K�rnchenzellen, metachromasierende Zellen)

Cited by 9 publications

References 24 publications

Spontaneous decidual reactions and menstruation in the black mastiff bat, Molossus ater

Spontaneous decidual reactions and menstruation in the black mastiff bat, Molossus ater

The Neglected Uterine NK Cells/Hamperl Cells/Endometrial Stromal Granular Cell, or K Cells: A Narrative Review from History through Histology and to Medical Education

The Basal or Indifferent Cell and the Ciliary Vacuole in the Oviducal Epithelium of the Long-Tongued Bat, Glossophaga Soricina

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