“…The epimerization of the genins, rather, can be regarded as a process of detoxification because the 3dehydro-and 3-epimetabolites exert biological effects which are much weaker or almost negligible in comparison with the parent compounds (Repke, 1961). The detoxification of the epi-derivatives is then completed by formation of their glucuronides (Lauterbach and Repke, 1960) or sulfates (Herrmann and Repke, 1962). On the whole, the short lifetime of aglycones in the body (Repke, 1962) apparently is due to the rapid processes of epimerization and conjugation as pictured in Figure 2.…”