�ber die vor�bergehende Hemmung der mechanischen Aktivit�t glatter Muskel nach Steigerung der extracellul�ren Kaliumkonzentration

Klingenberg, H. G.

doi:10.1007/bf00362773

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…The excitatory response of the portal vein on reduction of [K+]o and the complete cessation of spontaneous activity on return to normal solution were described in'our previous report (Axelsson et at. 1967) and similar reactions have been observed in other smooth muscles as mentioned above (Kuschinsky, Liillmann and Mosler 1960, Klingenberg 1962, Kuriyama 1963. The possibility that membrane permeability to potassium is reduced in the portal vein at low [K+]o was considered in our previous study (Axelsson et at.…”

Section: Discussionsupporting

confidence: 79%

“…With this in mind, attempts were made in the present study to eliminate the immediate portal vein responses to changes in [K"], and [Cl-], by altering these ion concentrations in such a way that their product remained constant (cf. Klingenberg 1962). This procedure would prevent net transfer of the ions across the cell membranes if K+ and Clwere distributed according to a Donnan equilibrium.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Holman (1958) and Kuriyama (1963) reported that the immediate effect of potassium-free solution on the taenia coli was depolarization and increased activity but hyperpolarization occurred on prolonged exposure. Studies on spontaneously active preparations from guinea pig uterus and frog stomach have shown that an increase in the external potassium ion concentration inhibits transiently the activity of these muscles (Klingenberg 1962). In potassium-free solution the isolated rat uterus developed a "contracture" upon which phasic contractions were -superimposed (Kuschinsky, Liillmann and Mosler 1960).…”

mentioning

confidence: 99%

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Similarities between the Vascular Smooth Muscle Responses to Sudden Changes in External Potassium, Sodium and Chloride Ion Concentrations

Johansson¹,

Jonsson²

1968

Acta Physiologica Scandinavica

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JOHANSSOX, B. and 0. JONSSON. Similarities between the vascular smooth muscle responses to sudden changes in external potassium, sodium and chloride ion concentrations. Acta physiol. scand. 1968. 73. 365-378. The effects of graded reductions in cxtracellular potassium, sodium and chloride concentrations on the spontaneous electrical and mechanical activity of the isolated rat portal vein have been studied. The immediate responses obtained on marked reduction in these ion concentrations and on readministration of normal solution were common to the three ion species and differed from the long-term effect of thi: ionic environment. Thus abrupt large reductions in the concentration of any of the three ions resulted in a transient excitation whereas return to normal Krebs solution led to a temporary complete inhibition of muscle activity. These initial, transient responses could in many cases not be predicted on the basis of the "constant field equation" by merely inserting the actual ion concentration values. However, if the concentrations of chloride and potassium ions (or chloride and sodium ions) were changed in a reciprocal manner no such transient responses occurred. Some possible explanations for this difference between the immediate and long-term effects of a changed ionic environment are discussed.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Similarities between the Vascular Smooth Muscle Responses to Sudden Changes in External Potassium, Sodium and Chloride Ion Concentrations

Johansson¹,

Jonsson²

1968

Acta Physiologica Scandinavica

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“…In the taenia, it is shown from the osmotic effect that the Donnan equation cannot be applied when the external K concentration is raised (Casteels & Kuriyama, 1966;Brading & Tomita, 1968). It is reported that in the guinea-pig uterus and the frog stomach (Klingenberg, 1962) and in the rat portal vein (Johannsson & Jonsson, 1968), the transient inhibition of motility by increasing the external K concentration is blocked when the K concentration is raised keeping the product of K and Cl constant, so as not to disturb their Donnan distribution. Further experiments are necessary to explain the apparent difference in the taenia from other smooth muscles.…”

Section: Discussionmentioning

confidence: 99%

“…In the isolated rat uterus (Kushinsky, Lifilman & Mosler, 1961) and in the rat portal vein (Axelsson, Wahlstr6m, Johansson & Jonsson, 1967;Johansson & Jonsson, 1968) K-free solution causes an increase of the frequency of mechanical contractions, and transient cessation of the spontaneous contractions is produced by restoring the normal K concentration. Studies on spontaneously active preparations from the guinea-pig uterus and the frog stomach have also shown that an increase in the external K ion concentration transiently inhibits the activity of these muscles (Klingenberg, 1962). These changes of mechanical activity are probably correlated with electrical changes.…”

Section: Introductionmentioning

confidence: 99%

Effects of removing the external potassium on the smooth muscle of guinea‐pig taenia coli

Tomita¹,

Yamamoto²

1971

The Journal of Physiology

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SUMMARY1. Removal of the external K ions depolarized the membrane of the guinea-pig taenia coil by about 5 mV, and increased the frequency of the spontaneous spike activity. After about 20 min in K-free solution, the frequency gradually decreased and spontaneous activity stopped after about 60 min.2. Readmission of K produced a transient hyperpolarization by 10-15 mV for 10-20 min, and lowered the excitability. The membrane resistance decreased during the hyperpolarization. When the external K concentration was returned to normal before the spontaneous activity had disappeared in K-free solution, there was a complete suppression of the spontaneous electrical and mechanical activities, accompanied by hyperpolarization of the membrane. The duration of this suppression of electrical and mechanical activities depended on the exposure time to K-free solution, the recovery being delayed by longer exposure.3. The effects of removing external K were essentially the same in the presence of tetrodotoxin (10-7 g/ml.), of atropine (10-6 g/ml.), and also in low Cl (2-7 mM).4. The effects of ouabain (10-6 g/ml.) were similar to those of zero K but appeared more slowly. After treatment with ouabain, the membrane was hyperpolarized by removing the external K and there was no hyperpolarization nor suppression of the mechanical activity on readmission of external K.5. Rb substitution for K produced little effect and addition of 5-9 mM-Rb after K-removal produced a typical suppression of activity as the readmission of K. When K was replaced with an equimolar concentration of Cs, the effects were similar to those produced by K-free solution.6. The pattern of the response to a change in the external K concentration was different below 230 C. The spontaneous activity was suppressed by removal of K, and increased by returning the external K.

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Erregung und Kontraktion glatter Vertebratenmuskeln

Schatzmann¹

1964

Ergebnisse Der Physiologie, Biologischen Chemie Und Experimentellen Pharmakologie

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�ber die vor�bergehende Hemmung der mechanischen Aktivit�t glatter Muskel nach Steigerung der extracellul�ren Kaliumkonzentration

Cited by 4 publications

References 9 publications

Similarities between the Vascular Smooth Muscle Responses to Sudden Changes in External Potassium, Sodium and Chloride Ion Concentrations

Similarities between the Vascular Smooth Muscle Responses to Sudden Changes in External Potassium, Sodium and Chloride Ion Concentrations

Effects of removing the external potassium on the smooth muscle of guinea‐pig taenia coli

Erregung und Kontraktion glatter Vertebratenmuskeln

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