�ber die Verteilung von Glykosidasen, Esterasen und Eiwei�bausteinen im Saccus endolymphaticus des Meerschweinchens

The morphological substrate of Menière's disease is the endolymphatic hydrops. That can be idiopathic or secondary as a sequence of a labyrinthine disease of another cause. It is possible to coordinate function loss of the sensory end-organs and pathohistological findings, but not all failures are light-microscopically explainable. The reason for the hydrops is certainly a disturbance in the endolymph physiology. For the pathogenesis are important, besides the biochemistry of the inner ear-fluids, problems of the membranes and pathological changes on ductus and saccus endolymphaticus and perimacular areals and plana semilunata. The perilymphatic space, documentated on the example of the secondary hydrops, is certainly not only passively enrolled in the procedure. All observations bring the initiation and periodicity of attacks to another point of view. A complete solution has not been possible so far, especially in the case of the etiology in idiopathic hydrops.

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Distribution and possible function of lysosomal enzymes in the inner ear under normal and pathophysiological conditions

Schätzle¹

1976

Arch Otorhinolaryngol

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The normal distribution of several lysosomal enzymes was studied in 20 guinea pigs. In the outer hair cells lysosomal enzymes are mainly localized at the apical cell pole, while in inner hair cells the distribution was uniform. Nonlysosomal enzymes like alcaline phosphatase are of predominantly basal localization. The concentration of some lysosomal enzymes like N-acetyl-beta-glucosaminidase was higher in outer than in inner hair cells while others like acid phosphatase, beta-glucuronidase and sulfatase showed a stronger reaction in the inner hair cells. After 10 days of sound overstimulation with 120 dB for 1 h a day, there was an increase of lysosomal enzyme content namely in the outer hair cells. There was no change of non-lysosomal enzymes. Under these conditions there might be a partial destruction of cellular organelles eliminated by lysosomal activity without loss of a total cell. In addition the distribution and possible function of lysosomal enzymes in other labyrinthine tissues was discussed.

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�ber die Verteilung von Glykosidasen, Esterasen und Eiwei�bausteinen im Saccus endolymphaticus des Meerschweinchens

Cited by 9 publications

References 14 publications

Investigation on resorption of the endolymph in the inner ear of the guinea-pig

Investigation on resorption of the endolymph in the inner ear of the guinea-pig

Pathohistologie des Ductus und Saccus endolymphaticus beim Innenohrhydrops

Distribution and possible function of lysosomal enzymes in the inner ear under normal and pathophysiological conditions

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