�ber die Induktionsf�higkeit der verschiedenen Bezirke der Neurula von Urodelen

Mangold, O.

doi:10.1007/bf01503740

Cited by 288 publications

(89 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These and subsequent experimental embryological and teratogenic experiments, mainly in amphibians, lead to the concept of a distinct "head organizer" for the organizer activity responsible for anterior, cephalic development, whereby a second head could be induced (Spemann, 1931;Mangold, 1933;Niehrs, 1999;Nieto 1999;Stern, 2005). For example, grafts of the dorsal lip of "early" amphibian gastrulae or "early" Henson's node of chicks are able to induce secondary axes possessing a full range of identities, whereas grafts of late gastrulae induced only posterior structures (Spemann, 1931(Spemann, , 1938Mangold, 1933;Holfreter, 1938;Dias and Schoenwolf, 1990;Storey et al, 1992;Foley and Stern, 2001;Gerhart, 2001). Fate maps in gnathostomes have typically demonstrated that the axial mesoderm (or mesendoderm) migrating out of the dorsal lip and node comes to underlie the future neural plate and that this mesendoderm can induce neural tissue (see below).…”

Section: Ahead Of Jaw Developmentmentioning

confidence: 99%

“…Developmental biologists have long held that the AME (historically, the anterior archenteron roof/prechordal plate) is in some way integral to the normal formation of the head (e.g., Adelmann, 1922Adelmann, , 1936Adams, 1924;Dart, 1924;Aasar, 1931;Waddington, 1932Waddington, , 1933Waddington, , 1936Waddington, , 1937Waddington, , 1962Mangold, 1933;Huxley and de Beer, 1934;Wright and Wagner, 1934;Spemann, 1938;Nieuwkoop, 1952;Juriloff et al, 1985;Sulik and Johnston, 1982;Elinson and Kao, 1993;Niehrs, 1999;Roessler and Muenke, 2001). Significantly, there is a long history of evidence for an inductive capacity in the AME: heterotopic grafting of the AME in amphibians or chicks has been shown to lead to ectopic head structures (Spemann, 1931(Spemann, , 1938Mangold, 1933;Pera and Kessel, 1997;Zoltewicz and Gerhart, 1997;Kieker and Niehrs, 2001).…”

Section: From Organizer To Mesendoderm To Pharyngeal Endoderm: Succesmentioning

confidence: 99%

“…Significantly, there is a long history of evidence for an inductive capacity in the AME: heterotopic grafting of the AME in amphibians or chicks has been shown to lead to ectopic head structures (Spemann, 1931(Spemann, , 1938Mangold, 1933;Pera and Kessel, 1997;Zoltewicz and Gerhart, 1997;Kieker and Niehrs, 2001). In mice, grafts of the axial mesendoderm in conjunction with a grafted AVE have been shown to induce anterior ectodermal markers such as Otx2 (Tam and Steiner, 1999).…”

Section: From Organizer To Mesendoderm To Pharyngeal Endoderm: Succesmentioning

confidence: 99%

See 2 more Smart Citations

21^st Century neontology and the comparative development of the vertebrate skull

Depew

Simpson

2006

Developmental Dynamics

View full text Add to dashboard Cite

Classic neontology (comparative embryology and anatomy), through the application of the concept of homology, has demonstrated that the development of the gnathostome (jawed vertebrate) skull is characterized both by a fidelity to the gnathostome bauplan and the exquisite elaboration of final structural design. Just as homology is an old concept amended for modern purposes, so are many of the questions regarding the development of the skull. With due deference to Geoffroy-St. Hilaire, Cuvier, Owen, Lankester et al., we are still asking: How are bauplan fidelity and elaboration of design maintained, coordinated, and modified to generate the amazing diversity seen in cranial morphologies? What establishes and maintains pattern in the skull? Are there universal developmental mechanisms underlying gnathostome autapomorphic structural traits? Can we detect and identify the etiologies of heterotopic (change in the topology of a developmental event), heterochronic (change in the timing of a developmental event), and heterofacient (change in the active capacetence, or the elaboration of capacity, of a developmental event) changes in craniofacial development within and between taxa? To address whether jaws are all made in a like manner (and if not, then how not), one needs a starting point for the sake of comparison. To this end, we present here a "hinge and caps" model that places the articulation, and subsequently the polarity and modularity, of the upper and lower jaws in the context of cranial neural crest competence to respond to positionally located epithelial signals. This model expands on an evolving model of polarity within the mandibular arch and seeks to explain a developmental patterning system that apparently keeps gnathostome jaws in functional registration yet tractable to potential changes in functional demands over time. It relies upon a system for the establishment of positional information where pattern and placement of the "hinge" is driven by factors common to the junction of the maxillary and mandibular branches of the first arch and of the "caps" by the signals emanating from the distal-most first arch midline and the lamboidal junction (where the maxillary branch meets the frontonasal processes). In this particular model, the functional registration of jaws is achieved by the integration of "hinge" and "caps" signaling, with the "caps" sharing at some critical level a developmental history that potentiates their own coordination. We examine the evidential foundation for this model in mice, examine the robustness with which it can be applied to other taxa, and examine potential proximate sources of the signaling centers. Lastly, as developmental biologists have long held that the anterior-most mesendoderm (anterior archenteron roof or prechordal plate) is in some way integral to the normal formation of the head, including the cranial skeletal midlines, we review evidence that the seminal patterning influences on the early anterior ectoderm extend well beyond the neural plate and are just as importan...

show abstract

Section: Ahead Of Jaw Developmentmentioning

confidence: 99%

Section: From Organizer To Mesendoderm To Pharyngeal Endoderm: Succesmentioning

confidence: 99%

Section: From Organizer To Mesendoderm To Pharyngeal Endoderm: Succesmentioning

confidence: 99%

See 1 more Smart Citation

21^st Century neontology and the comparative development of the vertebrate skull

Depew

Simpson

2006

Developmental Dynamics

View full text Add to dashboard Cite

show abstract

“…While Spemann (1927;see also pp. 187-188, Spemann, 1938) initially thought that planar signals contributed to neural induction, two lines of evidence suggested that vertical interactions were more important: Mangold's (1933) "einsteck" experiments showing that signals passing vertically from underlying mesoderm to the ectoderm could induce neural tissue and Holftreter's (1933) demonstration that exogastrulae, which were thought to have planar signals but not vertical ones, appeared to have no neural structures. There is evidence that the lateral limits of the neural plate are established by homeogenetic, planar signals passing laterally from the midline of the prospective neural plate (Nieuwkoop, 1985;Servetnick and Grainger, 1991).…”

Section: Introductionmentioning

confidence: 99%

Planar induction of convergence and extension of the neural plate by the organizer of Xenopus

Keller

Shih

Sater

et al. 1992

Developmental Dynamics

122

View full text Add to dashboard Cite

This paper demonstrates that convergence and extension within the neural plate of Xenopus laevis are regulated by planar inductive interactions with the adjacent Spemann organizer. The companion article (Keller et al.: Developmental Dynamics 193:199-217, 1992) showed that the prospective hindbrain and spinal cord occupy a very short and very wide area just above the Spemann organizer in the early gastrula and that these regions converge and extend greatly during gastrulation and neurulation, using a sequence of radial and mediolateral cell intercalations. In this article, we show that "planar" contact of these regions with the organizer at their vegetal edge until stage 11 is sufficient to induce convergence and extension, after which their convergence and extension become autonomous. Grafts of the organizer in planar contact with uninduced ectodermal tissues induce these ectoderma1 tissues to converge and extend by a planar inductive signal from the organizer. Labeling of the inducing or responding tissues confirms that only planar interactions occur. Neural convergence and extension are actually hindered in explants deliberately constructed so that vertical interactions occur. These results show unambiguously that the Spemann organizer induces the extraordinary and precocious convergence and extension movements of the Xenopus neural plate by planar interactions acting over short distances.

show abstract

“…Local A-P properties of dorsal mesoderm at the neural plate stage are clearly illustrated by the regionalized neural-inducing ability of portions of dorsal mesoderm taken from different positions along the presumptive A-P axis (1). The mechanisms leading to the regionalization of dorsal mesoderm, however, are still very poorly understood.…”

mentioning

confidence: 99%

Anteroposterior neural tissue specification by activin-induced mesoderm

Green

Cook

Smith

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The transforming growth factor ␤ superfamily member, activin, is able to induce mesodermal tissues in animal cap explants from Xenopus laevis blastula stage embryos. Activin can act like a morphogen of the dorsoventral axis in that lower doses induce more ventral, and higher doses more dorsal, tissue types. Activin has also previously been reported to induce neural tissues in animal caps. From cell mixing experiments it was inferred that this might be an indirect effect of induced mesoderm signaling to uninduced ectoderm. Here we demonstrate directly that neural tissues do indeed arise by the action of induced mesoderm on uninduced ectoderm. Dorsal mesoderm is itself subdivided into posterior and anterior domains in vivo, but this had not been demonstrated for induced mesoderm. We therefore tested whether different concentrations of activin recreate these different anteroposterior properties as well. We show that the anteroposterior positional value of induced mesoderm, including its neuroinductive properties, depends on the dose of activin applied to the mesoderm, with lower doses inducing more posterior and higher doses giving more anterior markers. We discuss the implications of these results for patterning signals and the relationship between anteroposterior and dorsoventral axes.

show abstract

�ber die Induktionsf�higkeit der verschiedenen Bezirke der Neurula von Urodelen

Cited by 288 publications

References 0 publications

21^st Century neontology and the comparative development of the vertebrate skull

21^st Century neontology and the comparative development of the vertebrate skull

Planar induction of convergence and extension of the neural plate by the organizer of Xenopus

Anteroposterior neural tissue specification by activin-induced mesoderm

Contact Info

Product

Resources

About

�ber die Induktionsf�higkeit der verschiedenen Bezirke der Neurula von Urodelen

Cited by 288 publications

References 0 publications

21st Century neontology and the comparative development of the vertebrate skull

21st Century neontology and the comparative development of the vertebrate skull

Planar induction of convergence and extension of the neural plate by the organizer of Xenopus

Anteroposterior neural tissue specification by activin-induced mesoderm

Contact Info

Product

Resources

About

21^st Century neontology and the comparative development of the vertebrate skull

21^st Century neontology and the comparative development of the vertebrate skull