�ber die chronische Arsenvergiftung der Moselwinzer unter besonderer Ber�cksichtigung des Arsenkrebses

Roth, F.

doi:10.1007/bf00524493

Cited by 80 publications

(14 citation statements)

References 13 publications

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“…A full enquiry was then undertaken which showed that air in the sheep dip factory contained up to 1000 parts/106 of arsenic, that many of the workers had signs of arsenicism (Perry et al, 1948), and that the numbers of deaths among the workers which had been attributed to cancers of the skin and lung were disproportionately high (Hill and Faning, 1948). A similar association between the cutaneous signs of arsenicism and lung cancer was subsequently reported on clinical examination of gold miners in Rhodesia (Osburn, 1969), and in necropsy studies of vineyard workers in the Moselle region who had used large quantities of arsenical insecticides and had drunk contaminated wine (Roth, 1956), and of nickel and cobalt smelters in Germany who had worked with ores mined in Schneeberg and Jachymov (Rockstroh, 1959).…”

Section: From Yamagiwa To Todaysupporting

confidence: 55%

Part III: 7th Walter Hubert lecture. Pott and the prospects for prevention

Doll¹

1975

Br J Cancer

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Section: From Yamagiwa To Todaysupporting

confidence: 55%

Part III: 7th Walter Hubert lecture. Pott and the prospects for prevention

Doll¹

1975

Br J Cancer

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“…It is well known that hyperpigmentation, keratosis, and cancer are the major manifestations of chronic arsenicism from any source (4), but peripheral circulatory disorders have also been reported occasionally in chronic arsenicism (5)(6)(7)(8)(9). It seems reasonable to assume that arsenic may be the common etiological factor for skin cancer and blackfoot disease.…”

mentioning

confidence: 99%

“…Regarding peripheral circulatory disorders, at least 15 cases of chronic arsenicism have been reported with gangrene of the extremities (5,7,8,(13)(14)(15)(16)(17)(18)(19). Although detailed pathologic observations on autopsy specimens or amputated limbs are lacking in the cases reported, the gangrene appears to result from arteriosclerosis and thromboangiitis obliterans (5).…”

mentioning

confidence: 99%

Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic

Tseng¹

1977

Environ Health Perspect

672

311

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In a limited area on the southwest coast of Taiwan, where artesian well water with a high concentration of arsenic has been used for more than 60 years, a high prevalence of chronic arsenicism has been observed in recent years. The total population of this “endemic” area is approximately 100,000. A general survey of 40,421 inhabitants and follow-up of 1,108 patients with blackfoot disease were made. Blackfoot disease, so-termed locally, is a peripheral vascular disorder resulting in gangrene of the extremities, especially the feet. The overall prevalence rates for skin cancer was 10.6 per 1000, and for blackfoot disease 8.9 per 1000. Generally speaking, the prevalence increased steadily with age in both diseases. The prevalence rates for skin cancer and blackfoot disease increased with the arsenic content of well water, i.e., the higher the arsenic content, the more patients with skin cancer and blackfoot disease. A dose–response relationship between blackfoot disease and the duration of water intake was also noted. Furthermore, the degree of permanent impairment of function in the patient was directly related to duration of intake of arsenical water and to duration of such intake at the time of onset. The most common cause of death in the patients with skin cancer and blackfoot disease was carcinoma of various sites. The 5-year survival rate after the onset of blackfoot disease was 76.3%; the 10-year survival rate was 63.3% and 15-year survival rate, 52.2%. The 50% survival point was 16 years after onset of the disease. Images FIGURE 1. FIGURE 2.

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“…IT HAS BEEN clearly established that skin cancer is one of the sequelae of exposure to arsenic, whether heavy environmental (Bergoglis, 1964;Yeh, 1973), industrial (Neubauer, 1947;Roth, 1956;Rockstoh, 1959) or medicinal (Hutchinson, 1888;Neubauer, 1947;Evans, 1976), and that lung cancer can be produced at high levels of airborne inorganic arsenicals, as in pesticide workers (Ott et al, 1974;Mabuchi et al, 1980), sheep-dip manufacturers (Hill & Fanning, 1948) and copper smelters (Lee & Fraumeni, 1969;Tokudome & Kuratsune, 1976;Axelson et al, 1978). The position about other cancers is less clear, and opinion ranges from the belief that arsenic has a carcinogenic effect on a wide range of internal organs (Dobson & Pinto, 1966;Regelson et al, 1968;Ott et al, 1974) to its having a protective effect (Frost,1.977).…”

mentioning

confidence: 99%

Medicinal arsenic and internal malignancies

Cuzick¹,

Evans²,

Gillman³

et al. 1982

Br J Cancer

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Summary.-A mortality analysis has been carried out on a cohort of patients given Fowler's solution (potassium arsenite) for periods ranging from 2 weeks to 12 years between 1945 and 1969. An excess of fatal and non-fatal skin cancer was apparent, but there was no overall excess mortality from cancer. Further analyses by site of cancer, dose level, and time from first exposure are also presented. A subset of patients were examined in 1969-70 for the presence of arsenical keratoses, hyperpigmentation and skin cancer. About half the patients had one or more of these signs. Although the cancer mortality of this entire subgroup was similar to the expected value, all the cancer deaths occurred in patients with prior signs of arsenicism. These data suggest that while any excess of internal malignancy due to the use of Fowler's solution is small or non-existent, there may be a susceptible subgroup which can be identified from dermatological manifestations.IT HAS BEEN clearly established that skin cancer is one of the sequelae of exposure to arsenic, whether heavy environmental

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�ber die chronische Arsenvergiftung der Moselwinzer unter besonderer Ber�cksichtigung des Arsenkrebses

Cited by 80 publications

References 13 publications

Part III: 7th Walter Hubert lecture. Pott and the prospects for prevention

Part III: 7th Walter Hubert lecture. Pott and the prospects for prevention

Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic

Medicinal arsenic and internal malignancies

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