�ber die Blutversorgung der menschlichen Retina unter der Einwirkung ver�nderter Sauerstoffspannung, von Kohlens�ure, Hyperventilation und Adrenalin

Huerkamp, B; Rittinghaus, F. W.

doi:10.1007/bf00405166

Cited by 23 publications

(2 citation statements)

References 36 publications

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“…Previous attempts to determine drug effects on retinal circulation generally have been based on inspections of the diameters of retinal vessels (Porsaa 1941, Huerkamp & Rittinghaus 1950, Thurhnsky 1957, Dollery, Hill & Hodge 1963). However, Frayser & Hickam (1964, 1965 combined vessel diameter measurements with determinations of retinal arterio-venous oxygen differences, which…”

Section: P Vr02 and Retinal Blood Flowmentioning

confidence: 99%

Effects of Norepinephrine, Angiotensin, Dihydroergotamine, Papaverine, Isoproterenol, Histamine, Nicotinic Acid, and Xanthinol Nicotinate on Retinal Oxygen Tension in Cats

Alm

1972

Acta Ophthalmologica

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The oxygen tension in the vitreous body close to the retina, P,,02, was determined continuously in cats. The effects on Pvr02 of intraarterial injections of various vasoactive drugs were determined. The vasoconstrictors norepinephrine, angiotensin and dihydroergotamine did not change PvrOZ in five cats. The same result was obtained with the vasodilators isoproterenol, histamine and xanthinol nicotinate in five cats, and with nicotinic acid in six cats, while papaverine invariably increased Pvro2 in seven cats when injected intraarterially and in two cats when injected intravenously. It is suggested that the ability to penetrate the blood-retinal barrier may play an important role in determining the effect of vasoactive drugs on retinal blood flow.

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Section: P Vr02 and Retinal Blood Flowmentioning

confidence: 99%

Effects of Norepinephrine, Angiotensin, Dihydroergotamine, Papaverine, Isoproterenol, Histamine, Nicotinic Acid, and Xanthinol Nicotinate on Retinal Oxygen Tension in Cats

Alm

1972

Acta Ophthalmologica

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“…It is well-known that the retinal vessels in man are very responsive to variations in oxygen tension. Cusick and co-workers (8) first reported that the retinal vessels dilate at low ambient oxygen tensions and constrict at high tensions and this finding has been confirmed by many investigators (26,31). The response to oxygen is apparent within a minute and is unaffected by thoracic sympathectomy.…”

Section: Retinal Tissue Hypoxia--a Common Factor For Retinal Changesmentioning

confidence: 80%

DIABETIC VASCULAR DISEASE:The Importance of Insulin Deficiency, Hyperglycemia and Hypophosphatemia on Red Cell Oxygen Unloading1

Ditzel

1977

Acta Paediatrica

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Diabetes is associated with a fluctuating impairment in oxygen transport of the erythrocytes. This impairment is correlated with hyperglycemia by the formation of glycosylated hemoglobin (HbA,,) and with inhibitory factors of glycolysis i.e. hypophosphatemia and acidosis which lower the concentration of red cell 2,3-diphosphoglycerate. Diabetic angiopathy may be the ultimate result of innumerable microvascular responses to discrete hypoxic injuries associated with increased plasma permeation through the vessel walls. It is shown that two additional risk factors for atherosclerosis-smokg and hypertriglyceridemia may also lead to arterial wall hypoxia by changing the position of the oxyhemoglobm dissociation curve. KEY WORDS: Diabetic angiopathy, red cell oxygen unloading, oxyhemoglobin dissociation curve, 2,3-diphosphoglycerate, plasma inorganic phosphate, insulin Acta Pat-diatr Scand Suppl270 8-77288 I

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Diseases of the Retina

Maumenee¹

1952

Archives of Ophthalmology

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�ber die Blutversorgung der menschlichen Retina unter der Einwirkung ver�nderter Sauerstoffspannung, von Kohlens�ure, Hyperventilation und Adrenalin

Cited by 23 publications

References 36 publications

Effects of Norepinephrine, Angiotensin, Dihydroergotamine, Papaverine, Isoproterenol, Histamine, Nicotinic Acid, and Xanthinol Nicotinate on Retinal Oxygen Tension in Cats

Effects of Norepinephrine, Angiotensin, Dihydroergotamine, Papaverine, Isoproterenol, Histamine, Nicotinic Acid, and Xanthinol Nicotinate on Retinal Oxygen Tension in Cats

DIABETIC VASCULAR DISEASE:The Importance of Insulin Deficiency, Hyperglycemia and Hypophosphatemia on Red Cell Oxygen Unloading1

Diseases of the Retina

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