�ber die Beziehungen zwischen elektromyographischen und anatomischen Befunden in normalen Muskeln und bei neuromuskul�ren Erkrankungen

Wohlfart, Gunnar; Feinstein, B.; Fex, Jörgen

doi:10.1007/bf00347856

Cited by 8 publications

(1 citation statement)

References 37 publications

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“…In the context of chronic partial denervation, the reinnervation of muscle fibers via collateral sprouting from surviving motor axons, and its effect upon muscle strength has been appreciated for over 70 years 16,17 . The clinical importance of these observations was quickly recognized and studied over several decades in a range of disorders, including ALS, 18‐23 polio, 20,24,25 spinal muscular atrophy, 26 and neuropathies 27 . Our finding of similar strength changes in the MUSIX‐UP and MUSIX‐STABLE groups, despite significantly different levels of motor unit loss, is thus in agreement with longstanding literature and indicates that MUSIX detects a clinically detectable/relevant reinnervation response.…”

Section: Discussionmentioning

confidence: 99%

Reinnervation as measured by the motor unit size index is associated with preservation of muscle strength in amyotrophic lateral sclerosis, but not all muscles reinnervate

et al. 2021

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Introduction/Aims: The motor unit size index (MUSIX) may provide insight into reinnervation patterns in diseases such as amyotrophic lateral sclerosis (ALS). However, it is not known whether MUSIX detects clinically relevant changes in reinnervation, or if all muscles manifest changes in MUSIX in response to reinnervation after motor unit loss.Methods: Fifty-seven patients with ALS were assessed at 3-month intervals for 12 months in four centers. Muscles examined were abductor pollicis brevis, abductor digiti minimi, biceps brachii, and tibialis anterior. Results were split into two groups: muscles with increases in MUSIX and those without increases. Longitudinal changes in MUSIX, motor unit number index (MUNIX), compound muscle action potential amplitude, and Medical Research Council strength score were investigated.Results: One hundred thirty-three muscles were examined. Fifty-nine percent of the muscles exhibited an increase in MUSIX during the study. Muscles with MUSIX increases lost more motor units (58% decline in MUNIX at 12 months, P < .001) than muscles that did not increase MUSIX (34.6% decline in MUNIX at 12 months, P < .001). However, longitudinal changes in muscle strength were similar. When motor unit loss was similar, the absence of a MUSIX increase was associated with a significantly greater loss of muscle strength (P = .002).

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