�ber die Bestimmung von Insulin im Blute am epididymalen Fettanhang der Ratte mit Hilfe markierter Glucose

Pfeiffer, E. F.; Pfeiffer, M.; Ditschuneit, H.; Ahn, Chang-Su

doi:10.1007/bf01486387

Cited by 33 publications

(1 citation statement)

References 11 publications

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“…Several •authors have shown an impaired initial insulin secretory response to OGTT in chemical and slight maturity-onset diabetes (Pfeiffer, Pfeiffer, Ditschuneit and Chang-Su-Ahn 1959, Pfeiffer, Ditschuneit and Ziegler 1960/61, Yalow and Berson 1960, Perley and Kipnis 1966, Cerasi, Efendic and Luft 1973, Fujita, Herron and Se/tzer 1975. Their observations are weil in accordance with our results: the not sufficient insulin infusion during the first minutes of OGTT, when type I algorithms were controlling the artificial beta cell, causes a glucose curve typical for a latent diabetic condition.…”

Section: Discussion and Conc1usionsmentioning

confidence: 99%

Attempts at Perfect Normalization of Glucose Tolerance Test of Severe Diabetics by Artificial Beta Cell

Kerner¹,

Thum²,

Tamas³

et al. 1976

Horm Metab Res

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The artificial beta cell is a Glucose Controlled Insulin (and dextrose) Infusion System (GCIIS) for maintaining normoglycemia in diabetic conditions and other disturbances of metabolism. The insulin and dextrose infusion rates are calculated by a microcomputer according to the static glucose concentration (proportional control) and to its rate of change (dynamic control). The algorithms controlling the computer can be adapted to the subjects' requirements. It has already been shown, that the artificial beta cell is able to maintain blood sugar values in diabetics within physiological ranges during the course of the day. In our present study we examined the response of the artificial beta cell using a 100 gm oral glucose load in severe diabetics. The first type of control algorithms applied effected a rather small initial insulin infusion following OGTT in 8 juvenile diabetics connected with the artificial beta cell. The glucose responses thus obtained were similar to latent diabetes. In contrast, when the computer was controlled by the second type of algorithms with a more responsive dynamic control and a consequently higher initial insulin infusion, in one diabetic OGTT was fully normalized, whereas an improvement was achieved in another diabetic patient. Furthermore it was shown that control algorithms must be varied individually, depending on residual beta cell function and glucose regulatory mechanisms.

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Section: Discussion and Conc1usionsmentioning

confidence: 99%