�ber die bakteriostatische Wirkung einiger Derivate des 5-Oxytetracyclins

E, Jeney; Zsolnai, T

doi:10.1007/bf00628521

Cited by 3 publications

(2 citation statements)

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“…More interestingly studies have discovered that these compounds exhibit diverse medical functions such as antimetabolism and antitubercular properties. 21,22 Isatin is an endogenous compound identified in humans that possesses wide range of biological activities. Isatin has anxiogenic, 23 anticonvulsant 24 activity and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro.…”

Section: Introductionmentioning

confidence: 99%

One-pot rapid and efficient synthesis of new spiro derivatives of 11H-indeno[1,2-b]quinoxalin-11-one, 6H-indeno[1,2-b]pyrido[3,2-e]pyrazin-6-one and isatin-based 2-pyrazolines

Azizian¹,

Shaabanzadeh²,

Hatamjafari³

et al. 2006

Arkivoc

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Some new spiro derivatives (5a-h, 9a-c and 13a-c) of 11H-indeno[1,2-b]quinoxalin-11-ones 1a-b and 6H-indeno[1,2-b]pyrido[3,2-e]pyrazin-6-one 6 and isatin 10 were synthesized by two different pathways. The chalcones 4a-h, 8a-c and 12a-c were prepared by the reaction of acetophenone and its four derivatives with 1a-b, 6 and 10 via base-catalyzed condensation followed by addition of acid. In the first procedure, the chalcones were isolated and reacted with hydrazine hydrate to give products. In the second procedure, the chalcones were in situ reacted with hydrazine hydrate without isolation to give spiro compounds in improved yields.

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Section: Introductionmentioning

confidence: 99%

One-pot rapid and efficient synthesis of new spiro derivatives of 11H-indeno[1,2-b]quinoxalin-11-one, 6H-indeno[1,2-b]pyrido[3,2-e]pyrazin-6-one and isatin-based 2-pyrazolines

Azizian¹,

Shaabanzadeh²,

Hatamjafari³

et al. 2006

Arkivoc

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“…antivirale [7], tuberculostatische [8] und wachstumsregulierende [9,10] Wirkungen nachgewiesen. Dagegen stehen Untersuchungen zu algiziden oder algistatischen Effekten und Diskussionen quantitativer Zusammenhänge zwischen chemischer Struktur und biologischer Aktivität für diese Wirkstoffgruppe bisher aus.…”

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Beziehungen zwischen algistatischer Aktivität und physikalisch-chemischen Eigenschaften von 5-Amino-1-aryl-1H-tetrazolen

Schelenz¹

2000

J. prakt. Chem.

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205 5-Amino-1-aryl-1H-tetrazole verfügen mit muskelrelaxierenden und antiinflammatorischen [1,2], antiarthritischen, analgetischen und ulcustherapeutischen [3,4] sowie coccidiostatischen [5, 6] Eigenschaften über ein breites biologisches Wirkungsspektrum. Für isomere 5-Arylamino-1H-tetrazole und die unsubstituierte Leitstruktur 5-Amino-1H-tetrazol wurden darüber hinaus Abstract. A series of 20 5-amino-1-aryl-1H-tetrazoles was synthesized by diazotation of corresponding 1-amino-3-arylguanidines and tested for growth-inhibiting activity against autotrophic Chlorella vulgaris cultures. In the used tests the different algae growth was quantified by photometric measurements at 680 nm. From obtained dosage-effectivity relationships the reciprocal values of isoeffective concentrations c 50 were derived and defined as activity parameters A in QSAR (quantitative structure-activity relationship) studies. It could be shown that the algistatitic activity (log A) of the tested heterocycles strongly depends on hydrophobicity described by their octan-1-ol/water partition coefficients (log P). The calculated linear relationships between log A and log P can be significantly improved by separate treatment of meta-/paraand ortho-substituted compounds or using an indicator variable to describe the lower activity of ortho-substituted 5-amino-1-aryl-1H-tetrazoles in common regression equations. The results are discussed and compared with analogous QSAR found for earlier tested series of N-heterocycles and compounds with urea structure. Abb. 1 Über Extinktionsmessungen (E) erhaltene Wachstumskurven (a) wirkstoffbehandelter Chlorella-vulgaris-Kulturen(¿ c = 4,05×10 -3 mol l -1 , Ú c = 3,22×10 -3 mol l -1 , q c = 2,57×10 -3 mol l -1 , Î c = 2,06×10 -3 mol l -1 , p c = 1,61×10 -3 mol l -1 , + c = 1,03×10 -3 mol l -1 , c = 6,43×10 -4 mol l -1 , Kontrollkultur) und daraus resultierende Dosis-Wirkungs-Kurven (b) zur Ermittlung der Aktivitätsparameter log A 1 und log A 2 für die algistatische Wirksamkeit von 5-Amino-1-phenyl-1H-tetrazol (vgl. Text)

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