�ber den Bronchialkrebs arsengesch�digter Winzer

Roth, F.

doi:10.1007/bf00955191

Cited by 54 publications

(9 citation statements)

References 10 publications

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“…The spraying of pesticides containing inorganic arsenic compounds, predominantly of very low solubility, has also been associated with lung cancer among vintners in Germany and France (35,36). Unfortunately these reports are only case studies with some macroepidemiological evidence and cannot be used for dose-response discussions.…”

Section: Epidemiological Studiesmentioning

confidence: 99%

The carcinogenicity of arsenic.

Pershagen¹

1981

Environ Health Perspect

138

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A carcinogenic role of inorganic arsenic has been suspected for nearly a century. Exposure to inorganic arsenic compounds occurs in some occupational groups, e.g., among smelter workers and workers engaged in the production and use of arsenic containing pesticides. Substantial exposure can also result from drinking water in certain areas and the use of some drugs. Tobacco and wine have had high As concentrations due to the use of arsenic containing pesticides.Inorganic arsenic compounds interfere with DNA repair mechanisms and an increased frequency of chromosomal aberrations have been observed among exposed workers and patients.Epidemiological data show that inorganic arsenic exposure can cause cancer of the lung and skin. The evidence of an etiologic role of arsenic for angiosarcoma of the liver is highly suggestive; however, the association between arsenic and cancer of other sites needs further investigation. No epidemiological data are available on exposure to organic arsenic compounds and cancer. Animal carcinogenicity studies involving exposure to various inorganic and organic arsenic compounds by different routes have been negative, with the possible exception of some preliminary data regarding lung cancer and leukemia. Some studies have indicated an increased mortality from lung cancer in populations living near point emission sources of arsenic into the air. The role of arsenic cannot be evaluated due to lack of exposure data.Epidemiological data suggest that the present WHO standard for drinking water (50 ,g As/l.) provides only a small safety margin with regard to skin cancer.

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Section: Epidemiological Studiesmentioning

confidence: 99%

The carcinogenicity of arsenic.

Pershagen¹

1981

Environ Health Perspect

138

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“…It has been associated with the occurrence of three types of skin cancer -Bowen's disease, basal cell carcinoma, and 'squamous cell carcinoma (28). Arsenic-induced skin cancers have been observed among persons exposed occupationally to arsenic in the chemical (32) and wine-making (41) industries, as well as among persons exposed through the consumption of contaminated drinking water (44) or through the use of arsenical medications (28). The prevalence of arsenic-induced skin cancer appears to be related to total arsenic dose (29,44).…”

Section: Discussionmentioning

confidence: 99%

“…The arsenic increases breakage resistance ("hardens" the lead) and increases resistance to electrochemical corrosion (41).…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to arsine. An epidemiologic reappraisal of current standards.

Landrigan¹,

Costello²,

Stringer³

1982

Scand J Work Environ Health

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LANDRIGAN PJ, COSTELLO RJ, STRINGER WT. Occupational exposure to arsine: An epidemiologic reappraisal of current standards. Scand j work environ heaLth 8 (1982) 169-177. In an evaluation of chronic occupational exposure to arsine (AsHg), an epidemiologic survey was conducted at a lead-acid battery manufacturing plant. Personal (breathing zone) air samples were obtained for the measurement of exposure to arsine and particulate arsenic (As), and area air samples were also collected for the determination of arsenic trioxide (AS20g) vapor concentrations. For the quantification of arsenic absorption, total arsenic content was determined in duplicate 24-h urine samples. Arsine in 177 breathing-zone air samples ranged from nondetectable to 49 ,ug/m 3 . The highest levels were found in the battery formation area, where arsine is generated by the reaction of battery acid with lead-arsenic alloy. 'Exposures to particulate arsenic (maximum 5.1 ,ug/m 3 ) and to AS20g (maximum 0.44 ,ug/m 3 , expressed as As) were generally lower. Urine analysis showed that eight (20.5 0/0) of 39 production workers had urinary arsenic concentrations (corrected to a specific gravity of 1.024) of 50 ,ug/l (0.67 ,umol/l) or above, indicating increased arsenic absorption. None of eight office staff had elevated urinary arsenic levels. A close correlation was found between urinary arsenic concentration and arsine exposure (N = 47; r = 0.84; P = 0.0001). Arsine levels above 15.6 flg/m 3 were associated with urinary arsenic concentrations in excess of 50 ,ug/l (0.67 flmol/l). No correlation was found between urinary arsenic content and exposures to particulate arsenic or to AS20g. Consumption of neither seafood, red wine, tobacco, nor contaminated drinking Water accounted for urinary arsenic excretion. It was concluded that the current arsine exposure standard, 200 flg/m 3 , fails to prevent chronic increased absorption of trivalent arsenic from the inhalation of arsine.

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“…The study of the population living near a pesticide manufacturing plant revealed that it was also exposed to the risk of lung cancer (Matanoski et al, 1981). Case reports of arsenical pesticide applicators have demonstrated an association between arsenic exposure and lung cancer (Roth, 1958). A cross-sectional study of 40,000 Taiwanese exposed to arsenic in drinking water found significant excess of skin cancer prevalence by comparison to 7500 residents of Taiwan and Matsu who consumed relatively arsenic-free water (Tseng et al, 1968).…”

Section: -40mentioning

confidence: 99%

Bioremediation of Petroleum Hydrocarbon-Contaminated Soils, Comprehensive Report

Altman¹

2001

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�ber den Bronchialkrebs arsengesch�digter Winzer

Cited by 54 publications

References 10 publications

The carcinogenicity of arsenic.

The carcinogenicity of arsenic.

Occupational exposure to arsine. An epidemiologic reappraisal of current standards.

Bioremediation of Petroleum Hydrocarbon-Contaminated Soils, Comprehensive Report

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