�ber das Verh�ltnis Mitochondrien: Myofibrillen in den Herzmuskelzellen der Ratte bei Druckhypertrophie des Herzens

Poche, Reinhard; Mattos, Cassiano Moraes de Mello; Rembarz, Hans-Werner; Stoepel, K.

doi:10.1007/bf00544641

Cited by 68 publications

(12 citation statements)

References 19 publications

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“…Despite the fact that no mention was made by Srivastava of the presence of a sinus-sac, there may have been one present, as this structure is either small or weakly developed in the other genera of this subfamily. If Laurer's canal is proved to be present by future workers, this genus should be transferred to the Halipeginae Poche, 1926, where, although sharing some of its features with Deropegus…”

Section: Type-species Genolinea Lalicaudamentioning

confidence: 99%

The Hemiuroidea: terminology, systematics and evolution

Gibson¹,

Bray²

1979

Bulletin of the British Museum (Natural History) Zoology

151

191

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The history of the classification of the Hemiuroidea and the features which have been used as criteria for distinguishing the higher taxa, such as adult morphology, life-cycle patterns and cercarial anatomy, are discussed. It is suggested that the best basic criterion currently available is the functional morphology of the adult. Explanations of the terminology with comments on the systematic significance and possible function of the features used in the study of hemiuroid taxonomy are included. A classification of the Hemiuroidea is presented with keys and definitions of the taxa to the generic level. The classification and definitions are based, where possible, on original observations of sectioned material. The Hemiuroidea is divided into fourteen families. The Accacoeliidae contains the Accacoeliinae and Paraccacladiinae, the latter subfamily consisting of only one genus. The Azygiidae consists of two subfamilies, the Azygiinae and Leuceruthrinae. The Bathycotylidae, Isoparorchiidae and Ptychogonimidae contain single genera, while the Hirudinellidae contains three monotypic genera. The Bunocotylidae is Bull. Br. Mus. not. Hist. (Zool.

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Section: Type-species Genolinea Lalicaudamentioning

confidence: 99%

The Hemiuroidea: terminology, systematics and evolution

Gibson¹,

Bray²

1979

Bulletin of the British Museum (Natural History) Zoology

151

191

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“…4,5) Ultrastructural analysis of mitochondria is very important, and as an organelle which is extremely sensitive to hypoxia, it represents a structure of central importance in aerobic metabolism. 6) Mitochondria are the powerhouses of the cell where oxidative phosphorylation takes place to generate ATP. Oxidative phosphorylation involves the transfer of electrons to oxygen coupled to the synthesis of ATP.…”

mentioning

confidence: 99%

Pravastatin Protection from Cold Stress in Myocardium of Rats.

et al. 2003

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SUMMARYThe aim of this research was to evaluate the possible protective effect of pravastatin on ultrastructural alterations induced by cold stress in the myocardium of rats.Sixteen EPM-Wistar rats (Rattus norvegicus albinus) were used and distributed into four groups: 1) control; 2) pravastatin; 3) cold stress, and 4) pravastatin + cold stress. A daily oral dose of 10 mg/kg of weight of pravastatin was administered to each rat in groups 2 and 4 for 15 days. The stress induced by cold was obtained by keeping the group 3 and 4 rats in a freezer at -8°C for 4 hours. The animals were killed and the heart and fragments of the left ventricles (LV) were removed and processed prior to conducting electron microscopic analysis.The ultrastructural alterations in cardiomyocytes were quantified through the number of mitochondrial cristae pattern (cristalysis). The group subjected only to cold stress showed a significant increase in cristalysis (391.9) when compared with control group (42.0). In the cold stress and pravastatin pretreatment group, a statistically significant (96.9)*, P<0.05 cristalysis reduction was observed when compared with cold stress group. The mitochondrial cristalysis profiles of the control and pravastatin groups were 42.0 and 65.7, respectively.Cold stress induced a significant increase in the rate of mitochondrial cristalysis. In the group that received pravastatin and was exposed to cold stress, the drug protected the LV cardiomyocytes. This fact was confirmed by a reduction mitochondrial cristalysis pattern. (Jpn Heart J 2003; 44: 243-255)

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“…After 10 or more days the increases in myofibrillar mass (Table 5) and myofibrillar volume (Table 4) exceed those of the dry weight and of cell volume, respectively. An increase in fractional myofibrillar volume and an associated decrease in fractional mitochondrial volume have also been described in rat left ventricles hypertrophied after prolonged experimental hypertension (14). Meerson (15) has reported that constriction of the ascending aorta in rabbits causes a decrease in the left ventricular content of myofibrillar protein 2 days after operation and an increase after 1, VA, and 6 months.…”

Section: Myofibrillar Mass and Volume In Left Ventricular Hypertrophymentioning

confidence: 90%

“…If, as suggested for rabbit hearts by Hatt et al (18) and Meerson (15) there is a phase of increased myofibrillar degradation early after aortic constriction, this phase in the rat heart is presumably either over or counterbalanced by an even more marked increase in the rate of myofibrillar synthesis by the time our earliest (24-hour) samples were taken for analysis of sequestered Mg content. In this connection, Schreiber et al (19) have shown that the isolated perfused guinea pig heart subjected to ventricular overload incorporates 14 C-lysine into myosin at an increased rate as early as 3 hours after the aortic pressure is raised.…”

Section: Myofibrillar Mass and Volume In Left Ventricular Hypertrophymentioning

confidence: 99%

Myofibrillar Mass in Rat and Rabbit Heart Muscle: CORRELATION OF MICROCHEMICAL AND STEREOLOGICAL MEASUREMENTS IN NORMAL AND HYPERTROPHIC HEARTS

Page

Polimeni

Zak

et al. 1972

Circulation Research

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A sequestered fraction of myofibrillar magnesium presumably bound to thin filaments during polymerization of actin was used to determine myofibrillar mass in rat left ventricles and rabbit hearts. Myofibrillar volume was also determined by stereological measurements on electron micrographs of rat ventricles. Myafibrillar Mg (1.11 mmoles/kg dry ventricle) can be determined in glycerinated ventricle either by measuring 28 Mg-inexchangeable Mg or Mg remaining after extraction with EDTA, KC1, and a nonionic detergent. These measurements, combined with the Mg content of myofibrillar suspensions similarly extracted (3.2 mmoles/kg protein), indicated that myofibrillar mass was ~347 g myofibrillar protein/kg dry ventricle. In rabbit hearts, increases in myofibrillar Mg per unit dry weight were as follows: auricular appendage < right ventricle < left ventricle -interventricular septum. After production of left ventricular hypertrophy in rats by constriction of the ascending aorta, both myofibrillar Mg and volume increased within 24 hours. After 10 or more days, myofibrillar Mg and myofibrillar volume increased proportionately more than tissue dry mass and cell volume, and the ratio of mitochondrial volume to cell volume decreased. Portions of this work have been presented previously to the American Society for Clinical Investigation (J Clin Invest 50:72a, 1971) and to the International Physiological Congress, Munich, 1971 (Proc Int Union Physiol Sci 8: 133-134). KEY WORDSReceived October 18, 1971. Accepted for publication February 7, 1972. tissue may change. Although the myofibrillar proteins can be extracted and purified from homogenates of heart muscle, there are few reliable quantitative estimates of myofibrillar mass. The reason is that the procedures used for extraction may lead to an incorrect estimation, because the extraction is incomplete and contaminants from other cellular structures remain associated with the extracted components. These difficulties notwithstanding, the measurement of myofibrillar mass is crucial for the quantitative description of cardiac hypertrophy.For which is based on the determination of traces of magnesium sequestered in the myofibril, has the advantage that it is applicable to human material obtained at autopsy as well as experimental and biopsy material. Methods DETERMINATION OF MYOFIBRILLAR MASS FROM THE AMOUNT OF SEQUESTERED MYOFIBRILLAR MAGNESIUMIn one set of experiments, glycerinated unhomogenized left ventricles, for which the dry weight before glycerination was known, were minced; their membranous constituents and their content of Determination of Sequestered Myofibrillar Mg in Rat Ventricles.-The nonseptal portion of the rat's left ventricle, excised after stunning the animals, was cut away from the interventricular septum and divided into two roughly equal pieces. Both were immediately weighed. One piece was then dried to constant weight in a vacuum oven and reweighed to obtain the dry weight. After obtaining its wet weight, the other piece was plunged rapidly...

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�ber das Verh�ltnis Mitochondrien: Myofibrillen in den Herzmuskelzellen der Ratte bei Druckhypertrophie des Herzens

Cited by 68 publications

References 19 publications

The Hemiuroidea: terminology, systematics and evolution

The Hemiuroidea: terminology, systematics and evolution

Pravastatin Protection from Cold Stress in Myocardium of Rats.

Myofibrillar Mass in Rat and Rabbit Heart Muscle: CORRELATION OF MICROCHEMICAL AND STEREOLOGICAL MEASUREMENTS IN NORMAL AND HYPERTROPHIC HEARTS

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