�ber 2-Benzolsulfonylamino-5 (?-methoxy-�thoxy)-pyrimidin (Glycodiazin). V8

Gerhards, E; Kolb, K. H.; Schulze, P. E.

doi:10.1007/bf00543213

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Severe diarrhea probably reduces the absorption of glymidine (GERHARDS et al 1964). In hepatic patients with increased serum bilirubin, glymidine is displaced from protein binding, but the consequences are not clear (HELD et al 1973a).…”

Section: Glymidine Sodiummentioning

confidence: 97%

“…Approximatcly 6% of a dose is reeovered from feces, the remainder being eliminatcd in urine with a little less than 1% of a dose unehanged, 19°/" -37°/" as thc desmethyl metabolite and 56%-74% as earboxylic acid. The distrihution volume of glymidine is 0.1511kg (HELD 1980) and that of the desmethyl metabolite in one subject 0.1211kg (GERHARDS et al 1964;GERHARDS and KOLB 1965). Eighty percent of glymidine is bound to albumin (total binding 89%), between 5% and 10% to red blood cells, and 5%-10% present in free form.…”

Section: Glymidine Sodiummentioning

confidence: 99%

“…It is used in Japan. Glymidine is almost completely ahsorhcd, 89% -95% of oral radioaetivity being recovered in urine (GERHARDS et al 1964). The absolute bioavailability is not known.…”

Section: Glymidine Sodiummentioning

confidence: 99%

See 2 more Smart Citations

Clinical Pharmacology of Sulfonylureas

Groop¹,

Neugebauer²

1996

Oral Antidiabetics

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Section: Glymidine Sodiummentioning

confidence: 97%

Section: Glymidine Sodiummentioning

confidence: 99%

See 1 more Smart Citation

Clinical Pharmacology of Sulfonylureas

Groop¹,

Neugebauer²

1996

Oral Antidiabetics

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The comparative effects of barbituric acid and phenobarbital on blood glucose and insulin secretion in mice

1976

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The effects of barbituric acid and phenobarbital upon carbohydrate metabolism in mice were compared. An intraperitoneal dose of 100 mg/kg of barbituric acid increased blood glucose concentrations during an intravenous glucose tolerance test, but did not alter the rate of glucose disappearance from the blood. Barbituric acid also antagonized the hypoglycemic effect of intravenously administered tolbutamide. The same dose of phenobarbital had no effect. An in vitro concentration of 100 mug/ml of barbituric acid decreased the responsiveness of isolated mouse pancreatic islets to glucose stimulation (3.0 mg/ml D-glucose). Again phenobarbital, 100 mug/ml, was without effect. The structural similarities between barbituric acid, tolbutamide and alloxan suggest that the effects observed in these experiments might reflect a competition for binding to reactive sites on or within the pancreatic B-cell.

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Zur hormonellen Beeinflussung des Hexobarbitalschlafes der Ratte

Hempel¹

1968

Naunyn-Schmiedebergs Arch. Pharmak. u. Exp. Path.

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�ber 2-Benzolsulfonylamino-5 (?-methoxy-�thoxy)-pyrimidin (Glycodiazin). V8

Cited by 5 publications

References 17 publications

Clinical Pharmacology of Sulfonylureas

Clinical Pharmacology of Sulfonylureas

The comparative effects of barbituric acid and phenobarbital on blood glucose and insulin secretion in mice

Zur hormonellen Beeinflussung des Hexobarbitalschlafes der Ratte

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