(Benzyl isocyanide)gold(I) pyrimidine‐2‐thiolate complex: Synthesis and biological activity

Fereidoonnezhad, Masood; Shahsavari, Hamid R.; Lotfi, Elaheh; Babaghasabha, Mojgan; Fakhri, Motahareh; Faghih, Zeinab; Faghih, Zahra; Beyzavi, M. Hassan

doi:10.1002/aoc.4200

Cited by 14 publications

(4 citation statements)

References 51 publications

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“…Following enough confluence, the cells were treated with 25% trypsin-EDTA (Biosera, France) and subcultured. The cells were then washed, counted and prepared for cytotoxic MTT assay as previously described [23,24].…”

Section: Cell Lines and Cell Culturementioning

confidence: 99%

Cytotoxic Activity of Some Spirooxindole-4H-pyran Derivatives

Faghih

Divar

et al. 2019

JPRI

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Aims: Isatin is a honored scaffold and one of the most favorable class of heterocyclic systems that possesses many interesting biological activities and well-tolerated in humans. Here a series of fifteen spirooxindole-4H-pyran derivatives containing both isatin and pyran moieties (ICa-ICo) will be examine for their anti-cancer activity. Study Design: Cytotoxic evaluation of some spirooxindole-4H-pyran derivatives in two cancerous cell lines. Place and Duration of Study: Pharmaceutical Science Research Center and Shiraz Institute for Cancer Research, Medical School in Shiraz University of Medical Sciences, Shiraz, Iran, between June 2018 and July 2019. Methodology: MTT assay was used to evaluate the cytotoxic activities of these compounds. The anticancer properties of the tested compounds were determined using A549 and MCF-7 cell lines. Results: Among the tested compounds ICc, ICd and ICf showed the best cytotoxic activities against both cancerous cell lines. Compounds ICh and ICj showed desirable cytotoxic activities against A549 cell line. Compound ICb showed desirable cytotoxic activities against MCF-7 cell line. Conclusion: We conclude that the isatin-linked pyran analog can serve as a prototype molecule for further development of a new class of anticancer agents.

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Section: Cell Lines and Cell Culturementioning

confidence: 99%

Cytotoxic Activity of Some Spirooxindole-4H-pyran Derivatives

Faghih

Divar

et al. 2019

JPRI

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“…To harvest the cells, following 70-80% of confluency, HepG2 cells were washed and detached using 25% trypsin-EDTA (Biosera, UK). The cells were then washed, counted and prepared for cytotoxic MTT assay as previously described [10][11].…”

Section: Cell Culturementioning

confidence: 99%

Cytotoxic Activity of Some Azole Derivatives

Faghih¹,

Rezaei²,

Jamshidzade³

et al. 2018

Asian Pac J Cancer Biol

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Azole derivatives are an important class of compounds in medicinal chemistry with a wide variety of biological activities. We previously described synthesis and antimicrobial evaluations of some new Azole derivatives. Most of our compounds showed desirable activity against different species of microorganisms. Here, we chose seventeen of these compounds, in four different groups including imidazole (group a, 1a-6a), 2-methylimidazole (group b, 1b-4b), 2-methyl-4-nitroimidazole (group c, 1c-4c) and benzimidazole (group d, 1d-3d) to further evaluate their cytotoxic activities against a human cancer cell line (HepG2) in comparison to cisplatin using colorimetric MTT cytotoxic assay. We also compared their cytotoxic activities with clotrimazole to find the safer compounds as antimicrobial agents. Our results indicated that Azole compounds including 2b, 4c, 2d and 3d displayed desirable anti-tumor activities against HepG2 (IC50<50μM) and might be considered as potential anticancer agents for further studies. The o her compounds with less cytotoxicity compared to clotrimazole could introduce as good candidates for antimicrobial agents.

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“…However, the administration of platinum based drugs have limitations of adverse side effects and acquired or intrinsic drug resistance [6], and hence there is a necessity of newer chemotherapeutic agents which can replicate the effectiveness of cisplatin, and can overcome its side effects. The cytotoxic activity of different transition metal complexes have been researched [7], and within this field, significant approaches have been made in exploring the cytotoxic activity of gold complexes [8], and their ability to interact with DNA [2c, 9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological activities of imidazo[1,2-a]pyridine based gold(III) metal complexes

Kanthecha

Bhatt

Patel

2019

Heliyon

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Five imidazo [1,2- a ]pyridine derivatives and their Au(III) complexes were synthesized. The compounds were characterized by 1 H-NMR, 13 C-NMR, IR, mass, UV-visible, elemental analysis, conductivity and magnetic measurement studies. All the compounds were screened for diverse biological activities to check the effect of coordination of Au(III) with imidazo [1,2- a ]pyridine heterocycles. The DNA interaction ability of compounds were studied as the change in absorption maxima and position of HS-DNA in presence of compounds and viscosity measurement due to change in DNA length under the influence of compounds. The computational insight of compound-DNA interaction was taken in docking study. All the results suggest intercalation mode of binding. The cellular level cytotoxic nature of compounds was evaluated using trypan blue dye staining of dead cell in cell viability assay. The smearing of DNA was observed, while DNA extracted from S. pombe cells in presence of complexes was subjected to gel electrophoresis, which shows their toxic effect on DNA. The complexes were evaluated for cytotoxicity on human A549 (Lung adenocarcinoma) cell line by MTT assay (IC 50 values). The in vitro cytotoxicity in terms of LC 50 value was checked on a simple zoological organism, brine shrimp.

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(Benzyl isocyanide)gold(I) pyrimidine‐2‐thiolate complex: Synthesis and biological activity

Cited by 14 publications

References 51 publications

Cytotoxic Activity of Some Spirooxindole-4H-pyran Derivatives

Cytotoxic Activity of Some Spirooxindole-4H-pyran Derivatives

Cytotoxic Activity of Some Azole Derivatives

Synthesis, characterization and biological activities of imidazo[1,2-a]pyridine based gold(III) metal complexes

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