Benzyl ester dendrimer silicon phthalocyanine based polymeric nanoparticle for in vitro photodynamic therapy of glioma

Ma, Dongdong; Chen, Xiuqin; Wang, Yuhua; Guo, Qiumei; Ye, Qiuhao; Guo, Ruotao; Xiao, Shuanghuang; Ye, Qing; Huang, Yide; Peng, Yiru

doi:10.1016/j.jlumin.2018.12.012

Cited by 30 publications

(11 citation statements)

References 28 publications

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“…For photodynamic therapy of glioma, one study formulated the benzyl ester dendrimer silicon-polymeric nanoparticle PS. Under laser irradiation, the nanoparticle demonstrated high photo-cytotoxicity against U251 glioma cells (Ma et al, 2019). In addition, different contrast agents could be conjugated to the surface of a dendrimer with three-dimensional structure to create a multimodal imaging nanoparticle (Estelrich, Sanchez-Martin, & Busquets, 2015).…”

Section: Dendrimersmentioning

confidence: 99%

Immunoengineering in glioblastoma imaging and therapy

Zanganeh

Georgala

Corbo

et al. 2019

WIREs Nanomed Nanobiotechnol

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Patients diagnosed with glioblastoma have poor prognosis. Conventional treatment strategies such as surgery, chemotherapy, and radiation therapy demonstrated limited clinical success and have considerable side effects on healthy tissues. A central challenge in treating brain tumors is the poor permeability of the blood–brain barrier (BBB) to therapeutics. Recently, various methods based on immunotherapy and nanotechnology have demonstrated potential in addressing these obstacles by enabling precise targeting of brain tumors to minimize adverse effects, while increasing targeted drug delivery across the BBB. In addition to treating the tumors, these approaches may be used in conjunction with imaging modalities, such as magnetic resonance imaging and positron emission tomography to enhance the prognosis procedures. This review aims to provide mechanistic understanding of immune system regulation in the central nervous system and the benefits of nanoparticles in the prognosis of brain tumors. This article is characterized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Cells at the Nanoscale Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Section: Dendrimersmentioning

confidence: 99%

Immunoengineering in glioblastoma imaging and therapy

Zanganeh

Georgala

Corbo

et al. 2019

WIREs Nanomed Nanobiotechnol

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“…As well, the two axial positions of the tetravalent metal centres can be displaced by various substituents such as phenyl, 132 phenoxy, 25,126,128,131 siloxy, 121,126,131,133 alkynyl, 134 diethylaminophenoxyethoxy, 135 1benzylpiperidin-4-oxy, 136 and even graphene 137 or benzyl ester dendrimers. 138 For this reason, a number of symmetrically and asymmetrically substituted X 2 -SiPc and X 2 -GePc derivatives have been developed over the years. The majority of axially substituted systems can be prepared via nucleophilic substitution of Cl 2 -MPc 25,128,132,136,138 or (HO) 2 -MPc, 120,121,126,131 while there are also examples starting from DIII for silicon-based derivatives.…”

Section: Group 14 Phthalocyaninesmentioning

confidence: 99%

“…138 For this reason, a number of symmetrically and asymmetrically substituted X 2 -SiPc and X 2 -GePc derivatives have been developed over the years. The majority of axially substituted systems can be prepared via nucleophilic substitution of Cl 2 -MPc 25,128,132,136,138 or (HO) 2 -MPc, 120,121,126,131 while there are also examples starting from DIII for silicon-based derivatives. For example, Barker et al 132 first synthesised chloro phenyl silicon phthalocyanine chloride ((Cl)(Ph)-SiPc) by the reaction between DIII and phenyltrichlorosilane.…”

Section: Group 14 Phthalocyaninesmentioning

confidence: 99%

From chemical curiosity to versatile building blocks: unmasking the hidden potential of main-group phthalocyanines in organic field-effect transistors

et al. 2021

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“…al. [ 41 ] synthetized benzyl ester dendrimer silicon phthalocyanine (D-SiPc) and encapsulated it into amphiphilic block copolymers, methoxypolyethylene glycol-b-polylactic acid, MPEG 5000 -b-PLA 3000 , to form polymeric micelles. These exhibited high photo-cytotoxicity toward U251 glioma cells under laser irradiation, proving their potential for PDT.…”

Section: Phthalocyanine-polymeric Nanoparticle Delivery Systems For Cancer Photodynamic Therapymentioning

confidence: 99%

Recent Progress in Phthalocyanine-Polymeric Nanoparticle Delivery Systems for Cancer Photodynamic Therapy

2021

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This perspective article summarizes the last decade’s developments in the field of phthalocyanine (Pc)-polymeric nanoparticle (NP) delivery systems for cancer photodynamic therapy (PDT), including studies with at least in vitro data. Moreover, special attention will be paid to the various strategies for enhancing the behavior of Pc-polymeric NPs in PDT, underlining the great potential of this class of nanomaterials as advanced Pcs’ nanocarriers for cancer PDT. This review shows that there is still a lot of research to be done, opening the door to new and interesting nanodelivery systems.

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Benzyl ester dendrimer silicon phthalocyanine based polymeric nanoparticle for in vitro photodynamic therapy of glioma

Cited by 30 publications

References 28 publications

Immunoengineering in glioblastoma imaging and therapy

Immunoengineering in glioblastoma imaging and therapy

From chemical curiosity to versatile building blocks: unmasking the hidden potential of main-group phthalocyanines in organic field-effect transistors

Recent Progress in Phthalocyanine-Polymeric Nanoparticle Delivery Systems for Cancer Photodynamic Therapy

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