Benzoylation of an Enamine¹

Design, Synthesis and Bioactivity of Novel 2-Aroyl-5-alkylcyclopentanone Derivatives

“…[10] . 由于烯胺进行酰化时, 在相 邻羰基取代基较少的位置发生酰化反应, 副产物少, 因 此我们采用 2-取代环戊酮 6 与吗啡啉反应生成烯胺 7, 再进行酰化, 最后水解得到目标产物 9 [13] . 根据我们前期的一些研究结果 [5～9] , 烯醇方式的不同 可能导致化合物构效关系的不同, 尽管根据 Brown 等 [14] 的研究结果, 酰基环戊酮的烯醇方式主要采取环外烯醇 方式, 但考虑到本文所列化合物中含有多个位阻较大的 基团, 为了进一步了解目标化合物 9 采用环外还是环内 烯醇方式和指导今后的研究工作, 在目标化合物均不适 合进行单晶结构测定的情况下, 我们将目标化合物 9a 进 一步衍生, 与苯甲酰氯反应生成烯醇酯 10 (Eq.…”

Organic polarography

“…Phorone and semiphorone in hydra-tion and cyclization studies (178) and benzoyl group in 6,6-di-o-chlorobenzoyl-1morpholinocyclohexene-l (189) was detected by polarography. The products of the reaction of o-phenylenediamine with biacetyl-and methylglyoxal (1394) and with glycolaldehyde and glyceraldehyde (1395) were examined polarographically.…”

Trichloroacetylation of Some Cyclic Enamines.

“…A number of b-diketones had been prepared via acylation of enamines. [2][3][4] Besides the monoacylation of enamines, the diacylation of the same compounds at a-and aЈ-positions has been shown to be a possible reaction course, 5) however, we have rarely met a,aЈ-diacylated cyclic enamines in the literature which were synthesized by similar methods. The reaction of 1-(4-morpholino)cycloheptene with trifluoroacetic acid has been reported to give a diacetylated product, where more reactive enamines such as 1-(4-morpholino)cyclopentene has been reported to react even at low temperatures to give complicated reaction mixtures.…”