Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris

Sagransky, Matt; Yentzer, Brad A.; Feldman, Steven R.

doi:10.1517/14656560903277228

Cited by 88 publications

(93 citation statements)

References 61 publications

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“…3,19,24 BPO can prevent bacterial resistance, thus contributing to safer, more eco-responsible acne management. 25,26 Systemic medications for the treatment of acne are typically reserved for moderate and severe inflammatory acne, and include isotretinoin, antibacterials, and hormonal agents. 3 Isotretinoin is a systemic retinoid that is highly effective for acne but carries a large systemic AE profile.…”

Section: Options For Acne Therapymentioning

confidence: 99%

“…Incorporating BPO into one's treatment regimen can reduce antibiotic resistance when used with a topical antibiotic and can be used long-term. 25,26 Combination products that combine BPO are thus a reasonable alternative. Eady et al investigated the use of combination BPO and erythromycin treatment and its effects on P. acnes and erythromycin-resistant P. acnes and found combining medications results in greater reductions of bacterial counts and also better clinical outcomes in patients already colonized with resistant strains of P. acnes.…”

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confidence: 99%

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Retinoid plus antimicrobial combination treatments for acne

2012

Journal of the American Academy of Dermatology

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Background: Acne vulgaris is a chronic disease with several pathogenic factors. Multiple medications are typically used that can lead to nonadherence and treatment failure. Combination medications target multiple pathways of acne formation and may offer therapeutic benefit. Purpose: To explore the efficacy and tolerability of combination retinoid plus antimicrobial treatments in acne vulgaris. Methods: A PubMed and Google search was conducted for combination therapies of clindamycin and tretinoin, with secondary analysis of related citations and references. Similar searches were completed for the combination medications of benzoyl peroxide plus clindamycin or erythromycin, and for the combination therapy of adapalene and benzoyl peroxide. Results: Combination clindamycin phosphate and tretinoin gel was found to be more efficacious than monotherapy of either drug or its vehicle for acne, including inflammatory acne, and has a greater onset of action than either drug alone. Clindamycin phosphate and tretinoin gel was well-tolerated, and adherence to its use exceeded that of using both medications in separate formulations. Benzoyl peroxide-containing combination medications with clindamycin or erythromycin were both more effective in the treatment of acne than either drug alone. Both medications were well-tolerated, with dry skin being the most common adverse effect. Conclusions: Combination medications have superior efficacy and adherence, and have a similar tolerability profile compared with monotherapy of its components. Several studies have found antibiotic-containing combination products with a retinoid effective for acne. The use of antibiotic-containing combination medications for acne can lead to bacterial resistance. Due to this potential for bacterial resistance, benzoyl peroxide treatments are also recommended in combination with a retinoid.

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Section: Options For Acne Therapymentioning

confidence: 99%

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confidence: 99%

Retinoid plus antimicrobial combination treatments for acne

2012

Journal of the American Academy of Dermatology

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“…Retinoids specifically target comedones, whereas antimicrobial agents (e.g., clindamycin, erythromycin) and benzoyl peroxide are usually used for inflammatory papules and pustules. 2 Combining benzoyl peroxide with topical or oral antibiotic drugs reduces the risk of antibiotic resistance. 3 Other topical treatments include over-the-counter preparations containing salicylic acid and products combining several antiacne agents.…”

Section: The Type Of Lesion Determines the Choice Of Therapymentioning

confidence: 99%

Acne: Figure 1:

Freiman

Barankin

2012

CMAJ

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“…BPO is a mainstay of therapy for inflammatory acne and acts as an antibacterial and comedolytic agent 3,19,24. BPO can prevent bacterial resistance, thus contributing to safer, more eco-responsible acne management 25,26…”

Section: Introductionmentioning

confidence: 99%

Retinoid plus antimicrobial combination treatments for acne

Feneran¹,

Kaufman²,

Dabade³

et al. 2011

CCID

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Background:Acne vulgaris is a chronic disease with several pathogenic factors. Multiple medications are typically used that can lead to nonadherence and treatment failure. Combination medications target multiple pathways of acne formation and may offer therapeutic benefit.Purpose:To explore the efficacy and tolerability of combination retinoid plus antimicrobial treatments in acne vulgaris.Methods:A PubMed and Google search was conducted for combination therapies of clindamycin and tretinoin, with secondary analysis of related citations and references. Similar searches were completed for the combination medications of benzoyl peroxide plus clindamycin or erythromycin, and for the combination therapy of adapalene and benzoyl peroxide.Results:Combination clindamycin phosphate and tretinoin gel was found to be more efficacious than monotherapy of either drug or its vehicle for acne, including inflammatory acne, and has a greater onset of action than either drug alone. Clindamycin phosphate and tretinoin gel was well-tolerated, and adherence to its use exceeded that of using both medications in separate formulations. Benzoyl peroxide-containing combination medications with clindamycin or erythromycin were both more effective in the treatment of acne than either drug alone. Both medications were well-tolerated, with dry skin being the most common adverse effect.Conclusions:Combination medications have superior efficacy and adherence, and have a similar tolerability profile compared with monotherapy of its components. Several studies have found antibiotic-containing combination products with a retinoid effective for acne. The use of antibiotic-containing combination medications for acne can lead to bacterial resistance. Due to this potential for bacterial resistance, benzoyl peroxide treatments are also recommended in combination with a retinoid.

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Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris

Cited by 88 publications

References 61 publications

Retinoid plus antimicrobial combination treatments for acne

Retinoid plus antimicrobial combination treatments for acne

Acne: Figure 1:

Retinoid plus antimicrobial combination treatments for acne

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