2015
DOI: 10.1016/j.ejmech.2014.09.089
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Abstract: Discovered in late 1960, azoles are heterocyclic compounds class which constitute the largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical component that confers activity to azoles. Triazoles are obtained by a slight modification of this ring and similar or improved activities as well as less adverse effects are reported for triazole derivatives. Consequently, it is not surprising that benzimidazole/benzotriazole derivatives have been found to be biologically active. Si… Show more

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Cited by 152 publications
(85 citation statements)
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References 265 publications
(263 reference statements)
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“…The most promising heterocyclic compounds are azoles, [10][11][12][13][14] which are five-membered nitrogen heterocycles. The nitrogen-containing azole skeleton offers the advantage of two nitrogen heteroatoms in the ring, which has an important effect on structural modifications and biological interactions.…”
Section: Introductionmentioning
confidence: 99%
“…The most promising heterocyclic compounds are azoles, [10][11][12][13][14] which are five-membered nitrogen heterocycles. The nitrogen-containing azole skeleton offers the advantage of two nitrogen heteroatoms in the ring, which has an important effect on structural modifications and biological interactions.…”
Section: Introductionmentioning
confidence: 99%
“…唑类化 合物是一类重要而特殊的杂环, 包括五元唑杂环(如咪 唑类 [20] 、吡唑类 [21] 、噻唑类 [22] 、噁唑类 [23] 、三唑类 [24,25] 、 四唑类 [26] 等)及其稠合唑杂环(如苯并噻唑类 [27] 、苯并咪 唑类 [28,29] 、苯并三唑类 [30] 、咔唑类 [31,32] 等), 含有氮、氧 和/或硫等多个杂原子, 具有芳香性和丰富的电子, 这种 奇特结构不仅易通过多种非共价键力如配位键、氢键、 范德华力、π-π 堆积、疏水与静电作用等多种非共价键…”
Section: 超分子化学是一个高度交叉的活跃研究领域 在化 学unclassified
“…Moreover, 1,2,4 triazoles have been renowned scaffold in medicinal chemistry. It also reported infusion with different aromatic and heterocyclic rings to enhance biological activity such as quinoxalines , benzene , indole , pyridine , oxadiazoles , and piperazines . To get a synergetic effect of triazole and piperazines, fused heterocyclic compounds [1,2,4]triazolo[4,3‐ a ]piperazines were derived.…”
Section: Introductionmentioning
confidence: 99%