Benzopyrans, Biphenyls and Xanthones from the Root ofGarcinia liniiand their Activity againstMycobacterium tuberculosis

Abstract

A new benzopyran, (S)-3-hydroxygarcibenzopyran, and three new biphenyls, garcibiphenyl C, garcibiphenyl D, garcibiphenyl E, together with thirteen known compounds have been additionally isolated from the root of Garcinia linii. The structures of these new compounds were determined through spectral analyses. Among the isolates, 1,7-dihydroxy-3-methoxyxanthone and 1,5-dihydroxy-3-methoxyxanthone showed antitubercular activities with MICs of 3.1 +/- 0.5 and 6.3 +/- 1.0 microg/mL against Mycobacterium tuberculosis 90-221,387 in vitro, respectively.

Biphenyl Derivatives from Garcinia Schomburgkiana and the Cytotoxicity of the Isolated Compounds

“…H,13 C NMR and HMBC: Table 1. Differential NOE: irradiation of OMe (3.80) -2% enhancement of Constituents of the stems of Garcinia schomburgkiana Natural Product Communications Vol.…”

Search for antimycobacterial constituents from a Tibetan medicinal plant, Gentianopsis paludosa

“…Compounds 1-3 and 5 exhibited inhibitory activity (MIC = 128 μg/mL) whereas compounds 4, 6 and 7 were inactive (MIC > 128 μg/mL). While antimycobacterial activity has been previously demonstrated for some xanthone derivatives (Chen et al, 2006;Ghosal and Chaudhuri, 1975;Ghosal et al, 1978;Schaper et al, 1999;Suksamrarn et al, 2003), this is the first report on the antimycobacterial properties of 1 and 3. 1,7,8- Our continuous efforts in studying the chemical composition and biological activities of Tibetan medicines have now led to the isolation of antimycobacterial ingredients from G. paludosa.…”

A New Benzoylphloroglucinol Derivative with an Adamantyl Skeleton and Other Constituents from Garcinia multiflora: Effects on Neutrophil Pro‐Inflammatory Responses

“…Plants of this genus contain a variety of secondary metabolites including xanthones [2 -6], benzophenones [7] [8], phloroglucinols [7] [9] [10], terpenoids [9] [10], biflavonoids [11], and their derivatives. Many of these compounds exhibit antioxidant [2] [3] [8], trypanocidal [4], cytotoxic [5] [7] [8], antitubercular [6], anti-inflammatory [9] [10], and anti-HIV [11] activities.…”