Benzophenone UV-Photoinitiators Used in Food Packaging: Potential for Human Exposure and Health Risk Considerations

Snedeker, Suzanne M.

doi:10.1007/978-1-4471-6500-2_6

Cited by 3 publications

(5 citation statements)

References 54 publications

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“…Benzophenone (BP) is an extremely versatile organic molecule known for its use in applications ranging from inks, imaging, and clear coatings for the printing and packaging industry, to therapeutic purposes. − Its most known attribute is related to its electronic structure, and particularly to the featured long-lived lowest-lying triplet state that can be easily generated at long wavelengths (>320 nm) . This makes of BP an ideal photoinitiator, as it was proven in photodynamic therapy: BP acts as a noncovalently bound photosensitizer, producing several photolesions to DNA .…”

Section: Introductionmentioning

confidence: 99%

Resolving the Singlet Excited State Manifold of Benzophenone by First-Principles Simulations and Ultrafast Spectroscopy

Segarra‐Martí

Zvereva

Marazzi

et al. 2018

J. Chem. Theory Comput.

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Accurate characterization of the high-lying excited state manifolds of organic molecules is of fundamental importance for the interpretation of the rich response detected in time-resolved nonlinear electronic spectroscopies. Here, we have characterized the singlet excited state manifold of benzophenone (BP), a versatile organic photoinitiator and a well-known DNA photosensitizer. Benchmarks of various multiconfigurational/multireference (RASSCF/PT2) and time-dependent density functional theory (TD-DFT) approaches allowed assignments of experimental linear absorption signals of BP in the ultraviolet (UV) region, with unprecedented characterization of ground state absorptions in the far UV. Experimental transient absorption spectra obtained by UV-vis pump-probe spectroscopy at very short time delays are shown to be directly comparable to theoretical estimates of excited state absorptions (from the low-lying nπ* and ππ* singlet states) in the Franck-Condon region. Multireference computations provided reliable interpretation of the PP spectra, with TD-DFT results yielding a fair agreement as long as electronic transitions featuring double excitations contributions are not involved. These results lay the groundwork for further computational studies and interpretation of experimental nonlinear electronic spectra of benzophenone in more complex systems, such as BP/DNA adducts.

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Section: Introductionmentioning

confidence: 99%

Resolving the Singlet Excited State Manifold of Benzophenone by First-Principles Simulations and Ultrafast Spectroscopy

Segarra‐Martí

Zvereva

Marazzi

et al. 2018

J. Chem. Theory Comput.

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“…Despite its extensive use BPA exposure is detrimental to human health and environment. [1][2][3] Humans are typically exposed to BPA through skin contact, dental fillings, medical equipment, or contaminated air. BPA has been detected in milk, human serum, amniotic fluid, saliva, and urine.…”

Section: Introductionmentioning

confidence: 99%

“…It is also associated with several cancers such as prostate cancer, liver cancer, and breast cancer. [3,6,7] Based on current research and health issues, it is important to detect the BPA level with lower concentration and high Bisphenol A exposure, even at very low concentrations, is associated with an increased risk of high blood pressure, heart disease, diabetes and some cancers. It is important to monitor BPA exposure level for human healthcare.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A Detection Using Molybdenum Disulfide (MoS₂) Field‐Effect Transistor Functionalized with DNA Aptamers

Hossain

Shabbir

Liu

et al. 2023

Adv Materials Technologies

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Bisphenol A exposure, even at very low concentrations, is associated with an increased risk of high blood pressure, heart disease, diabetes and some cancers. It is important to monitor BPA exposure level for human healthcare. Two‐dimensional materials‐based field‐effect transistors are promising for sensing applications due to their high sensitivity, label‐free detection, and reusability. Among 2D materials MoS2 based semiconductor materials provides higher sensitivity compared to the lack of sensitive existing graphene materials due to bandgap. In this work, a microfluidic device based on MoS2 field‐effect transistor is demonstrated that can be adapted to detect several biomolecules at very low concentrations. MoS2 channel is functionalized by depositing gold nanoparticles and immobilizing single one (or double)‐stranded DNA. It is found that dsDNA functionalized devices exhibit higher sensitivity compared to ssDNA for all BPA concentrations due to p‐doing effect of dsDNA on MoS2 semiconducting surface. Both ss and dsDNA functionalized MoS2 FET devices are able to detect BPA concentration as low as 1 pg mL−1, as observed by a 4.27% and 2.17% change in the current, respectively, and a response time of about ≈4 s. The demonstrated MoS2 FET sensors are very promising to detect lower concentration biomolecules and DNA in biomedical applications.

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“…A further concern are residual amounts of PIs, either as remainder of the UV-curing process or due to incomplete purification, since PI species are prone to migrate through the porous paperboard and secondary packaging to the food or beverage. They also can remain in the paperboard after the outer print layer is removed, and thus PIs can appear in new packaging made with recycled paperboard fibers [7].…”

Section: Introductionmentioning

confidence: 99%

“…Also, throughout the paper we are interested in PIs among the different components of the photopolymerizable formulations used for food packaging. A variety of factors have been shown to affect migration from the printed surface through the paperboard and to the food itself (direct contact), or from the paperboard through the vapor phase to the food (indirect contact) [7][8]. These factors include set-off [9][10], the vapor pressure of the UV photoinitiator [11], time and temperature of food storage [9][10]12], porosity and types of materials used for primary and secondary packaging, the fat and moisture content of the food, and whether the UV photoinitiator is present or not in recycled materials used to form new packaging.…”

Section: Introductionmentioning

confidence: 99%

Progress in the development of polymeric and multifunctional photoinitiators

Zhou

Allonas

Ibrahim

et al. 2019

Progress in Polymer Science

107

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Benzophenone UV-Photoinitiators Used in Food Packaging: Potential for Human Exposure and Health Risk Considerations

Cited by 3 publications

References 54 publications

Resolving the Singlet Excited State Manifold of Benzophenone by First-Principles Simulations and Ultrafast Spectroscopy

Resolving the Singlet Excited State Manifold of Benzophenone by First-Principles Simulations and Ultrafast Spectroscopy

Bisphenol A Detection Using Molybdenum Disulfide (MoS₂) Field‐Effect Transistor Functionalized with DNA Aptamers

Progress in the development of polymeric and multifunctional photoinitiators

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Benzophenone UV-Photoinitiators Used in Food Packaging: Potential for Human Exposure and Health Risk Considerations

Cited by 3 publications

References 54 publications

Resolving the Singlet Excited State Manifold of Benzophenone by First-Principles Simulations and Ultrafast Spectroscopy

Resolving the Singlet Excited State Manifold of Benzophenone by First-Principles Simulations and Ultrafast Spectroscopy

Bisphenol A Detection Using Molybdenum Disulfide (MoS2) Field‐Effect Transistor Functionalized with DNA Aptamers

Progress in the development of polymeric and multifunctional photoinitiators

Contact Info

Product

Resources

About

Bisphenol A Detection Using Molybdenum Disulfide (MoS₂) Field‐Effect Transistor Functionalized with DNA Aptamers