Benzophenone-3: Comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies

Mustieles, Vicente; Balogh, Ria K.; Axelstad, Marta; Montazeri, Parisa; Márquez, Sandra; Vrijheid, Martine; Draskau, Monica Kam; Taxvig, Camilla; Peinado, Francisco M. Ocaña; Berman, Tamar; Frederiksen, Hanne; Fernández, Mariana F.; Vinggaard, Anne Marie; Andersson, Anna‐Maria

doi:10.1016/j.envint.2023.107739

Cited by 38 publications

(17 citation statements)

References 172 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PCBs as well as some reproductive toxic phthalates (including butylbenzylphthalate), and PFOS have undergone regulatory restrictions, which should result in a reduction of human exposure to these compounds in the future. However, it is a surprise that the UV filter benzophenone-3 contributes relatively much to the total risk, although this is fully in line with the conclusions from a recent systematic, integrative review on this compound stating that human exposure levels achieved after a single whole-body sunscreen application are close to concentrations that have been reported to have endocrine disrupting effects ( Mustieles et al, 2023 ).…”

Section: Discussionsupporting

confidence: 53%

Human risk associated with exposure to mixtures of antiandrogenic chemicals evaluated using in vitro hazard and human biomonitoring data

Taxvig

Rodríguez-Carrillo

et al. 2023

Environment International

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 53%

Human risk associated with exposure to mixtures of antiandrogenic chemicals evaluated using in vitro hazard and human biomonitoring data

Taxvig

Rodríguez-Carrillo

et al. 2023

Environment International

View full text Add to dashboard Cite

“…Gaining a comprehensive understanding of the processes by which these metabolites interfere with endocrine pathways and affect ovarian function is essential for the development of successful treatments and interventions for these disorders [46]. Additional investigation is necessary to enhance our comprehension of the intricate problems related to female reproductive health, including the impacts of EDCs, circadian rhythm disruption, and toxicological data from biomonitoring investigations [45,47].…”

Section: Discussionmentioning

confidence: 99%

Investigating the Metabolomic Pathways in Female Reproductive Endocrine Disorders: A Mendelian Randomization Study

Lu,

Wang,

Yang

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Reproductive endocrine disorders (RED) including polycystic ovary syndrome (PCOS), endometriosis (EMs), and female infertility (FI), significantly affect women's health globally, with varying prevalence across different regions. These conditions can be addressed through medication, surgical interventions, and lifestyle modifications. However, the limited understanding of RED's etiology and the substantial economic burden of its treatment highlight the importance of investigating its pathogenesis. Metabolites play a critical role in metabolic processes and are potentially linked to the development of RED. Despite existing studies suggesting correlations between metabolites and RED, conclusive evidence remains scarce, primarily due to the observational nature of these studies, which are prone to confounding factors. Methods This study utilized Mendelian Randomization (MR) to explore the causal relationship between metabolites and RED, leveraging genetic variants associated with metabolite levels as instrumental variables to minimize confounding and reverse causality. Data were obtained from the Metabolomics GWAS Server and the IEU OpenGWAS project. Instrumental variables were selected based on their association with the human gut microbiota composition, and the GWAS summary statistics for metabolites, PCOS, EMs, and FI were analyzed. The MR-Egger regression and random-effects inverse-variance weighted (IVW) methods were employed to validate the causal relationship. Cochran's Q test was employed to evaluate heterogeneity, sensitivity analysis was performed using leave-one-out analysis, and for pleiotropy analysis, the intercept term of MR-Egger's method was investigated. Results The MR analysis revealed significant associations between various metabolites and RED conditions. For instance, a positive association was found between 1-palmitoylglycerophosphocholine and PCOS, while a negative association was noted between phenylacetate and FI. The study identified several metabolites associated with an increased risk and others with protective effects against PCOS, EMs, and FI. These findings highlight the complex interplay between metabolites and RED, suggesting potential pathways through which these conditions could be influenced or treated. Conclusion This MR study provides valuable insights into the causal relationship between metabolites and female reproductive endocrine disorders, suggesting that metabolic alterations play a significant role in the pathogenesis of PCOS, EMs, and FI, and offering a foundation for future research and therapeutic development.

show abstract

“…In the DPPH assay, 37 and 38 exhibited stronger scavenging potential for DPPH and ABTS radicals (IC 50 1.26 and 1.33 mg mL −1 , respectively for DPPH and 0.69 and 0.58 mg mL −1 , respectively for ABTS) compared to BHT (butylated hydroxytoluene, IC 50 16.27 mg mL −1 for DPPH) and ascorbic acid (IC 50 3.01 mg mL −1 for ABTS). 48 A novel derivative, rhizophol A (46) was isolated from the endophytic fungus Cytospora rhizophorae A761 and characterized by NMR and Xray, as well as quantum energy calculation.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Commonly, BP-3 and BP-1 are utilized as stabilizers to prevent photodegradation in many commercial products and as UV lters in cosmetics and sunscreens to prohibit skin damage and sunburn. 16 Various reviews focused on BPs reported from various plant families particularly those from family Clusiaceae, including their chemistry, structural determination, and bioactivities. 10,12,17 Also, in 2019, Mao et al summarized the reported studies regarding the BPs's occurrence and fate in the aquatic systems.…”

Section: Marburg Germanymentioning

confidence: 99%

See 1 more Smart Citation

Benzophenones-natural metabolites with great Hopes in drug discovery: structures, occurrence, bioactivities, and biosynthesis

Ibrahim,

Fahad ALsiyud,

Alfaeq

et al. 2023

RSC Adv.

View full text Add to dashboard Cite

show abstract

Benzophenone-3: Comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies

Cited by 38 publications

References 172 publications

Human risk associated with exposure to mixtures of antiandrogenic chemicals evaluated using in vitro hazard and human biomonitoring data

Human risk associated with exposure to mixtures of antiandrogenic chemicals evaluated using in vitro hazard and human biomonitoring data

Investigating the Metabolomic Pathways in Female Reproductive Endocrine Disorders: A Mendelian Randomization Study

Benzophenones-natural metabolites with great Hopes in drug discovery: structures, occurrence, bioactivities, and biosynthesis

Contact Info

Product

Resources

About