Benzodiazepines inhibit neutrophil chemotaxis and superoxide production in a stimulus dependent manner; PK-11195 antagonizes these effects

Diazepam-binding inhibitor-derived peptides induce intracellular calcium changes and modulate human neutrophil function

“…Indeed, synthetic pBR ligands modulate neutrophil chemotaxis and superoxide production [12,13], monocyte chemotaxis and production of cytokines [14][15][16], and peripheral blood mononuclear cell proliferation and cytokine secretion [17]. At present, however, the immune effects of DBI-derived peptides have received little attention, although at least some of them seem to affect important mechanisms in host defense and inflammation, such as cytokine production by human monocytes [15,16,18].…”

Peripheral Benzodiazepine Receptor Expression on Leukocytes and Neutrophil Function during Anticonvulsant Monotherapy

“…Most cellular components of the immune system are endowed with pBZrs, such as the thymus gland, spleen and lymph nodes [5], neutrophils [6], monocytes and macrophages [7][8][9], and lymphocytes [10]. Experimental evidence indicates that pBZrs are involved in the modulation of leukocyte function [9,[11][12][13][14], providing a possible explanation for the immunologic side effects of anticonvulsant drugs [15].…”

Diazepam, em dose única, inibe a migração celular, a estimulação macrofágica e a atividade de TNF-α na reação inflamatória aguda induzida por LPS em camundongos

“…A densidade de RPBs nas células do sistema imune, é maior que a concentração destes receptores no sistema neuroendócrino (Zavala et al, 1990), o que poderia explicar a ação imunomoduladora de alguns benzodiazepínicos, como a redução da resistência às infecções, redução do burst oxidativo e da fagocitose por macrófagos, inibição da quimiotaxia de células inflamatórias e diminuição da produção do ânion superóxido e de algumas interleucinas (Finnerty et al, 1991;Galdiero et al, 1995;Lazzarini et al, 2001Lazzarini et al, , 2003Massoco, Palermo-Neto, 1999Zhang, Morrison, 1993).…”