Benzodiazepines in the treatment of tinnitus

Lechtenberg, Richard; Shulman, Abraham

doi:10.1017/s1755146300090600

Cited by 25 publications

(23 citation statements)

References 6 publications

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“…This study is slightly complicated, as nine participants were given oxazepam in the first 2 weeks to alleviate expected worsening of distress. But oxazepam itself is a benzodiazepine, which may have an effect on tinnitus 55. Zöger et al52 reported 24% attrition in this study, but none of the dropouts had received oxazepam, suggesting that it may have affected their result.…”

Section: Resultsmentioning

confidence: 60%

Systematic review and meta‐analyses of randomized controlled trials examining tinnitus management

et al. 2011

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Objectives/HypothesisTo evaluate the existing level of evidence for tinnitus management strategies identified in the UK Department of Health's Good Practice Guideline.Study DesignSystematic review of peer-reviewed literature and meta-analyses.MethodsSearches were conducted in PubMed, Cambridge Scientific Abstracts, Web of Science, and EMBASE (earliest to August 2010), supplemented by hand searches in October 2010. Only randomized controlled trials that used validated questionnaire measures of symptoms (i.e., measures of tinnitus distress, anxiety, depression) were included.ResultsTwenty-eight randomized controlled trials met our inclusion criteria, most of which provide moderate levels of evidence for the effects they reported. Levels of evidence were generally limited by the lack of blinding, lack of power calculations, and incomplete data reporting in these studies. Only studies examining cognitive behavioral therapy were numerous and similar enough to perform meta-analysis, from which the efficacy of cognitive behavioral therapy (moderate effect size) appears to be reasonably established. Antidepressants were the only drug class to show any evidence of potential benefit.ConclusionsThe efficacy of most interventions for tinnitus benefit remains to be demonstrated conclusively. In particular, high-level assessment of the benefit derived from those interventions most commonly used in practice, namely hearing aids, maskers, and tinnitus retraining therapy needs to be performed.

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Section: Resultsmentioning

confidence: 60%

Systematic review and meta‐analyses of randomized controlled trials examining tinnitus management

et al. 2011

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“… 64 Lechtenberg and Shulman noted that clonazepam and oxazepam were effective in more than 50% of tinnitus cases. 65 However, when patients stopped taking either of these drugs, tinnitus recurred to its prior level or a worse level. 65 The only medication providing a reliable reduction of tinnitus is intravenous lidocaine, and there is a close association between the effects of lidocaine and oral carbamazepine.…”

Section: Treatmentsmentioning

confidence: 99%

“… 65 However, when patients stopped taking either of these drugs, tinnitus recurred to its prior level or a worse level. 65 The only medication providing a reliable reduction of tinnitus is intravenous lidocaine, and there is a close association between the effects of lidocaine and oral carbamazepine. 66 Intravenous lidocaine produces a change in the neural activity in the right temporal lobe in the auditory association cortex.…”

Section: Treatmentsmentioning

confidence: 99%

Tinnitus: Characteristics, Causes, Mechanisms, and Treatments

Han¹,

Lee

Kim³

et al. 2009

J Clin Neurol

218

147

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Tinnitus-the perception of sound in the absence of an actual external sound-represents a symptom of an underlying condition rather than a single disease. Several theories have been proposed to explain the mechanisms underlying tinnitus. Tinnitus generators are theoretically located in the auditory pathway, and such generators and various mechanisms occurring in the peripheral auditory system have been explained in terms of spontaneous otoacoustic emissions, edge theory, and discordant theory. Those present in the central auditory system have been explained in terms of the dorsal cochlear nucleus, the auditory plasticity theory, the crosstalk theory, the somatosensory system, and the limbic and autonomic nervous systems. Treatments for tinnitus include pharmacotherapy, cognitive and behavioral therapy, sound therapy, music therapy, tinnitus retraining therapy, massage and stretching, and electrical suppression. This paper reviews the characteristics, causes, mechanisms, and treatments of tinnitus.

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“…Einige Autoren stellten fest, die Verwendung der Substanz sei für den Langzeitgebrauch inakzeptabel (Emmet und Shea [12] bezüglich Carbamazepin) oder Patienten brachen aufgrund von Nebenwirkungen die Medikamenteneinnahme ab [37]. Eine längerfristige Einnahme wiederum war in den meisten Fällen aufgrund von unerwünschten Nebenwirkungen nicht möglich bzw.…”

Section: Psychologische Verfahren Können Längerfristige Effekte Und Kunclassified

Medikamentöse und psychologische Therapien bei chronischem subjektivem Tinnitus

Schilter¹,

Jäger²,

Heermann

et al. 2000

HNO

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A metaanalysis on pharmacological and psychological treatment reports was conducted in order to evaluate the overall effectiveness of these treatment conditions in chronic tinnitus. A totality of 109 treatment studies published between 1976 and 3/1995 and meeting minimal inclusion criteria was located, but only 24 studies reporting sufficient information could be analyzed. The methodological quality of the studies was evaluated by a coding scheme, and the resulting index of effectiveness has been weighted by this standard as well as by sample size. Effect sizes of pharmacological studies were ES = 1.27 and by this higher than the ones for psychological studies with ES = 0.88. This finding is attenuated by high (unspecific) placebo effects of ES = 0.65 in pharmacological studies compared to ES = 0.10 in psychological studies. In general, patients from psychological studies further improve after treatment in cases where catamnestic measurements have been conducted.

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Benzodiazepines in the treatment of tinnitus

Cited by 25 publications

References 6 publications

Systematic review and meta‐analyses of randomized controlled trials examining tinnitus management

Systematic review and meta‐analyses of randomized controlled trials examining tinnitus management

Tinnitus: Characteristics, Causes, Mechanisms, and Treatments

Medikamentöse und psychologische Therapien bei chronischem subjektivem Tinnitus

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