Benzodiazepines and Injurious Falls in Community Dwelling Elders

Pariente, Alexandre; Dartigues, Jean‐François; Bénichou, Jacques; Letenneur, Luc; Moore, Nicholas; Fourrier‐Réglat, Annie

doi:10.2165/00002512-200825010-00007

Cited by 152 publications

(94 citation statements)

References 52 publications

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“…In our study, only the chronic and current use of benzodiazepine was associated with a greater risk of falls in men and women aged 40 and older. The two-fold greater risk of recurrent falls among benzodiazepine users is similar to that described by Pariente et al 30 .…”

Section: Discussionsupporting

confidence: 86%

Risk factors for recurrent falls among Brazilian women and men: the Brazilian Osteoporosis Study (BRAZOS)

et al. 2010

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Section: Discussionsupporting

confidence: 86%

Risk factors for recurrent falls among Brazilian women and men: the Brazilian Osteoporosis Study (BRAZOS)

et al. 2010

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“…Several lists of explicit and implicit criteria have been developed for the surveillance of PIM use in a general elderly population [11][12][13]. The US Beers criteria have been widely used and were last updated in 2015 [14]. The Beers list reflects prescribing patterns and drugs marketed in the US.…”

Section: Introductionmentioning

confidence: 99%

Inappropriate prescribing for the elderly—a modern epidemic?

Nyborg

Straand

Brekke

2012

Eur J Clin Pharmacol

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“…Additional factors increasing surgical morbidity include longer operation time, excessive blood loss, and general anesthesia. Third, cognitive impairment and the use of benzodiazepines increases with age, as does the risk for falls and fractures [8,9]. Cognitively impaired elderly patients often develop postoperative delirium, which is associated with increased mortality, falls, and respiratory complications such as pneumonia.…”

mentioning

confidence: 99%

Climbing a long hill: pelvic floor surgery and the need for geriatric urogynecology

Betschart

Rizk

2014

Int Urogynecol J

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The topic of geriatric urogynecology is receiving much attention lately as a public health priority because of the global increase in female life expectancy and the significant risk of associated pelvic floor dysfunctions. Statistics from the USA project that in 2050, 25 % of the population will be >60 years and that those >85 will increase from a population of 1.9 % in 2010 to 4.3 % in 2050 [1]. The urogynecological community should thus expect to face a worldwide and progressively growing demand from patients seeking care for pelvic floor dysfunctions. One study predicted >50 % increased demand for urogynecological services over the next 40 years [2].The changing female demographics is accompanied by a considerable interest in the contemporary literature to standardize the indications, techniques, and outcomes of surgical treatment of pelvic floor dysfunctions. Only a few reports appreciate that increasing age of our female population is an intrinsic biological variable interfering with the standardization process [3]. Women aged >80 years undergoing urogynecological surgery have a 13.6 higher risk of postoperative death than their younger counterparts. In the majority of cases, the cause of death is not directly related to the procedure [4]. Despite the obvious need for operative intervention among these elderly women and the strong evidence for the inherent morbidity and mortality of this treatment option, there is scarce urogynecological data on the risks and specific perioperative management in this patient group. Ageing influences lower urinary tract symptoms (LUTS), pelvic floor function, and perioperative and postoperative courses. The higher postoperative morbidity rate is also an important factor that is often overlooked in most surgical studies. Main concerns when treating elderly women are:(1) Functional aging with myogenic and neurological changes (2) Polypharmacy (3) Impaired cognitive function and risk of delirium First, considering functional aging, it is traditionally believed that aging is simply a physiological phenomenon caused by a gradual and exponential decline in the functional reserve. Aging, however, is a complex and evolutionary spectrum of innate and progressive events affecting molecules, cells, and the entire organism and is caused by free radicals, nonenzymatic glycosylation, and apoptosis [5]. The entire process is under the control of the endocrine systems-mainly growth hormone, estrogens, and androgens-with significant acceleration of the pace of ageing in women than in men [5]. Aging induces ultrastructural alterations in the urinary bladder that include apoptosis of the detrusor muscle, widening of the intercellular tight junctions, and degeneration of the axonal innervation [6]. These lesions may contribute to the development of functional disorders such as higher postvoid residual volumes, postoperatively impaired voiding dysfunction, or sensory micturition disturbances. The mechanism by which aging changes in the pelvic organs, particularly the urinary bladder, can influen...

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Benzodiazepines and Injurious Falls in Community Dwelling Elders

Cited by 152 publications

References 52 publications

Risk factors for recurrent falls among Brazilian women and men: the Brazilian Osteoporosis Study (BRAZOS)

Risk factors for recurrent falls among Brazilian women and men: the Brazilian Osteoporosis Study (BRAZOS)

Inappropriate prescribing for the elderly—a modern epidemic?

Climbing a long hill: pelvic floor surgery and the need for geriatric urogynecology

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