Benzo[a]pyrene alters vascular function in rat aortas ex vivo and in vivo

Tzeng, Huei‐Ping; Yang, Ting‐Hua; Wu, Cheng-Tien; Chiu, Hsien-Yi; Liu, Shing‐Hwa; Lan, Kuo‐Cheng

doi:10.1016/j.vph.2019.106578

Cited by 7 publications

(8 citation statements)

References 60 publications

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“…It has been classified as class I carcinogen by the International Agency for Research on Cancer (www.iarc.who.int). The exposure of BaP results in extensive and selective formation of BPDE, which has high interaction activity with DNA and forms a DNA adduct, the major mutagen in tobacco smoke ( 7 , 20 ). Properly speaking, BaP is a procarcinogen.…”

Section: Sources Metabolism and Tissue Toxicity Of Bapmentioning

confidence: 99%

“…Hypertension (HTN), also known as high blood pressure, is a long-term medical condition in which the blood pressure in the arteries is persistently elevated ( 7 ). HTN usually does not cause noticeable symptoms.…”

Section: Vascular Toxicity Effects and Underlying Mechanism Of Bapmentioning

confidence: 99%

“…Inhibitors of protein kinase C (PKC), MAPK, myosin light-chain kinase (MLCK) and Rho kinases significantly inhibit BaP-enhanced vasoconstriction ( Table 2 ). BaP induces ROS production in vascular smooth muscle cells in a time-dependent manner ( 7 ). Heart rate was not affected in BaP-treated sprague-dawley rats, however, weight loss, markedly elevated blood pressure ( 14 ).…”

Section: Vascular Toxicity Effects and Underlying Mechanism Of Bapmentioning

confidence: 99%

“…Cardiovascular diseases (CVDs) are associated with DNA damage, including DNA adduct and oxidative DNA damage, in both circulating and vessel-wall cells. And environmental chemical carcinogens have been identified to be as a risk factor for CVDs (7)(8)(9)(10). In addition, collective evidence from these studies revealed that the cardiovascular toxicity of foodborne contaminants is mainly attributed to PAHs, especially BaP.…”

Section: Introductionmentioning

confidence: 99%

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Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

et al. 2022

Front. Nutr.

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Benzo(a)pyrene (BaP) is a highly toxic and carcinogenic polycyclic aromatic hydrocarbon (PAH) whose toxicological effects in the vessel-wall cells have been recognized. Many lines of evidence suggest that tobacco smoking and foodborne BaP exposure play a pivotal role in the dysfunctions of vessel-wall cells, such as vascular endothelial cell and vascular smooth muscle cells, which contribute to the formation and worsening of cardiovascular diseases (CVDs). To clarify the underlying molecular mechanism of BaP-evoked CVDs, the present study mainly focused on both cellular and animal reports whose keywords include BaP and atherosclerosis, abdominal aortic aneurysm, hypertension, or myocardial injury. This review demonstrated the aryl hydrocarbon receptor (AhR) and its relative signal transduction pathway exert a dominant role in the oxidative stress, inflammation response, and genetic toxicity of vessel-wall cells. Furthermore, antagonists and synergists of BaP are also discussed to better understand its mechanism of action on toxic pathways.

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Section: Sources Metabolism and Tissue Toxicity Of Bapmentioning

confidence: 99%

Section: Vascular Toxicity Effects and Underlying Mechanism Of Bapmentioning

confidence: 99%

Section: Vascular Toxicity Effects and Underlying Mechanism Of Bapmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

et al. 2022

Front. Nutr.

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“…Transient receptor potential channels may be activated by oxidative stress; ROS levels in endothelial cells increase after treatment with ultrafine carbon black particles (Büchner et al, 2013). Increased ROS production has also been found in VSMCs in response to PAHs exposure (Tzeng et al, 2019), and it has been suggested that PAHs are able to induce oxidative stress in VSMCs. In addition, the components of PM 2.5 , including sulfate and manganese (Mn), are associated with increased oxidative stress (Ho et al, 2020).…”

Section: Pm25‐induced Vsmcs Damagementioning

confidence: 99%

Adverse effects of ambient fine particulate matter (PM_2.5) on vascular smooth muscle cells

Ming

Liu

et al. 2022

J of Applied Toxicology

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Cardiovascular diseases are the leading cause of death worldwide. Meanwhile, environment air pollution has become a serious health risk factor, contributing to the mortality of respiratory and cardiovascular diseases. A substantial body of evidence has shown that many types of vascular diseases are related to air pollution. The physiology and pathophysiology of the three layers of vascular vessels, especially the inner and medial layer, contribute to the process of vascular diseases. Vascular smooth muscle cells (VSMCs) are the predominant cells in the medial layer, and several studies have indicated that air pollution has an adverse effect on VSMCs. There are numerous sources of air pollution across the world, and the components of air pollutants are a complex mixture of gaseous pollutants and particulate matter. Among these air pollutants, particulate matter (PM)2.5 presents the highest risk factor leading to global mortality from cardiovascular disease and disability. In this review, we primarily focus on the impacts of PM2.5 exposure on VSMCs. We further discuss the correlation between exposure to PM2.5 and other vascular diseases and present potential protective and treatment strategies to decrease vascular mortality related to air pollution.

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Switch of phosphorylation to O-GlcNAcylation of AhR contributes to vascular oxidative stress induced by benzo[a]pyrene

Wang

Huang

Gan

et al. 2023

Food Science and Human Wellness

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Benzo[a]pyrene alters vascular function in rat aortas ex vivo and in vivo

Cited by 7 publications

References 60 publications

Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

Adverse effects of ambient fine particulate matter (PM_2.5) on vascular smooth muscle cells

Switch of phosphorylation to O-GlcNAcylation of AhR contributes to vascular oxidative stress induced by benzo[a]pyrene

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Benzo[a]pyrene alters vascular function in rat aortas ex vivo and in vivo

Cited by 7 publications

References 60 publications

Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

Adverse effects of ambient fine particulate matter (PM2.5) on vascular smooth muscle cells

Switch of phosphorylation to O-GlcNAcylation of AhR contributes to vascular oxidative stress induced by benzo[a]pyrene

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Adverse effects of ambient fine particulate matter (PM_2.5) on vascular smooth muscle cells