Benzimidazolium Salts Bearing Nitrile Moieties: Synthesis, Enzyme Inhibition Profiling, and Molecular Docking Analysis for Carbonic Anhydrase and Acetylcholinesterase
Erkan Öner,
Yetkin Gök,
Yeliz Demir
et al.
Abstract:This report presents the synthesis and characterization of a range of benzimidazolium salts featuring 3‐cyanopropyl groups on the 1st nitrogen atom and varied alkyl groups on the 3rd nitrogen atom within the benzimidazole structure. Benzimidazolium salts were synthesized by N‐alkylation of 1‐alkyl benzimidazole with 3‐cyanopropyl‐bromide. The new salts were characterized by 1H and 13C‐NMR, FT‐IR spectroscopic and elemental analysis techniques. In this study, the enzyme inhibition abilities of seven nitrile sub… Show more
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